Effects of Qindan Capsule (芩丹胶囊) on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin-II in spontaneous hypertensive rats

Wang Bo; Zhang  Ji-dong; Wang Shi-hua

doi:10.1007/s11655-001-0287-6

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Effects of Qindan Capsule (芩丹胶囊) on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin-II in spontaneous hypertensive rats

OriginalPaper | Updated：2021-08-27

- Effects of Qindan Capsule (芩丹胶囊) on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin-II in spontaneous hypertensive rats
- Effects of Qindan Capsule (芩丹胶囊) on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin-II in spontaneous hypertensive rats
- 中国结合医学杂志（英文版） 2006年12卷第4期页码：287-291
- Affiliations：
  
  1. Department of TCM, Qilu Hospital Affiliated to Shandong University,Jinan,China
  2. Department of Radioisotope, Qilu Hospital Affiliated to Shandong University,China
- Author bio：
- Funds：
  
  Supported by Administration of Traditional Chinese Medicine of Shandong Province (No. 1–60)
- DOI：10.1007/s11655-001-0287-6
  中图分类号：
- 纸质出版日期：2006，
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Wang, B., Zhang, Jd. & Wang, Sh. Effects of Qindan Capsule (芩丹胶囊) on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin-II in spontaneous hypertensive rats., Chin. J Integ. Med. 12, 287–291 (2006). https://doi.org/10.1007/s11655-001-0287-6

Wang Bo, Zhang Ji-dong, Wang Shi-hua. Effects of Qindan Capsule (芩丹胶囊) on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin-II in spontaneous hypertensive rats[J]. Chinese Journal of Integrative Medicine, 2006,12(4):287-291.
Wang, B., Zhang, Jd. & Wang, Sh. Effects of Qindan Capsule (芩丹胶囊) on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin-II in spontaneous hypertensive rats., Chin. J Integ. Med. 12, 287–291 (2006). https://doi.org/10.1007/s11655-001-0287-6 DOI：

Wang Bo, Zhang Ji-dong, Wang Shi-hua. Effects of Qindan Capsule (芩丹胶囊) on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin-II in spontaneous hypertensive rats[J]. Chinese Journal of Integrative Medicine, 2006,12(4):287-291. DOI： 10.1007/s11655-001-0287-6.

摘要

To observe the hypotensive effects of Qindan Capsule (芩丹胶囊

QC) on spontaneous hypertensive rats (SHR) and its effect on the contents of endothelin (ET)

calcitonin gene-related peptide (CGRP) and angiotensin-II (Ang-II) in plasma and vascular tissues

and to investigate the possible mechanism of QC in lowering blood pressure. Forty SHRs were divided into 5 groups: the high dosage QC group [QCHD

750 mg/(kg·d)]

the low dosage QC group [QCLD

150 mg/(kg·d)]

the Niuhuang Jiangya Pill group [牛黄降压丸

NJP

200 mg/(kg·d)]

the Captopril group [ 15 mg/(kg·d) ] and the model group

8 in each group. Meanwhile

a normal control group consisting of 8 WistarKyoto (WKY) rats was set up also. All the rats were administered with medicine through gastrogavage. Systolic blood pressure (SBP)

level of ET

CGRP and Ang-II in plasma and Ang-II in tissues of mesenteric artery were detected in all the rats after 12 weeks of treatment. The level of SBP after treatment in the QCHD group was lower than that in the model group (P < 0.01)

but with no significant difference as compared with that in the Captopril group and the NJP group (P > 0.05). After treatment

the plasma level of ET was lower and CGRP higher than those in the model group (both P < 0.05)

and also higher than those in the NJP and Captopril group (both P < 0.05). As for the content of Ang-II

in mesenteric arterial tissues

it was lower in the QCHD group than that in the model group (P < 0.05)

but in plasma

it showed no significant difference between the two groups (P > 0.05). QC has a satisfactory hypotensive action on SHR rats

and its mechanism may be associated with the regulation on plasma vasoactive peptide and regional renin-angiotensin system.

Abstract

To observe the hypotensive effects of Qindan Capsule (芩丹胶囊

QC) on spontaneous hypertensive rats (SHR) and its effect on the contents of endothelin (ET)

calcitonin gene-related peptide (CGRP) and angiotensin-II (Ang-II) in plasma and vascular tissues

and to investigate the possible mechanism of QC in lowering blood pressure. Forty SHRs were divided into 5 groups: the high dosage QC group [QCHD

750 mg/(kg·d)]

the low dosage QC group [QCLD

150 mg/(kg·d)]

the Niuhuang Jiangya Pill group [牛黄降压丸

NJP

200 mg/(kg·d)]

the Captopril group [ 15 mg/(kg·d) ] and the model group

8 in each group. Meanwhile

a normal control group consisting of 8 WistarKyoto (WKY) rats was set up also. All the rats were administered with medicine through gastrogavage. Systolic blood pressure (SBP)

level of ET

but with no significant difference as compared with that in the Captopril group and the NJP group (P > 0.05). After treatment

the plasma level of ET was lower and CGRP higher than those in the model group (both P < 0.05)

and also higher than those in the NJP and Captopril group (both P < 0.05). As for the content of Ang-II

in mesenteric arterial tissues

it was lower in the QCHD group than that in the model group (P < 0.05)

but in plasma

it showed no significant difference between the two groups (P > 0.05). QC has a satisfactory hypotensive action on SHR rats

and its mechanism may be associated with the regulation on plasma vasoactive peptide and regional renin-angiotensin system.

关键词

Qindan Capsulespontaneous hypertensive ratendothelincalcitonin generelated peptideangiotensin II

Keywords

Qindan Capsulespontaneous hypertensive ratendothelincalcitonin generelated peptideangiotensin II

references

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Takahashi K, Ouyang X, Komatsu K, et al. Sodium tanshinone II A sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochem Pharmacol 2002; 64(4): 745–749.

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Shao FM, Wang XY, Zhang XL, et al. The study of effect of earthworm extract on the renal hypertension. Chin J Integr Tradit West Nephrol 2001;2(2): 80–82.

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