Effect of traditional Chinese herbs combined with low dose human menopausal gonadotropin applied in frozen thawed embryo transfer

Zhang Hui-qin; Zhao Hong-xin; Gu Dun-yu; Jia Xiao-feng; Yan Bei; Cao Lin; Wang Lei; Shi  Hui-juan

doi:10.1007/s11655-006-0244-0

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Effect of traditional Chinese herbs combined with low dose human menopausal gonadotropin applied in frozen thawed embryo transfer

OriginalPaper | Updated：2021-08-27

- Effect of traditional Chinese herbs combined with low dose human menopausal gonadotropin applied in frozen thawed embryo transfer
- Effect of traditional Chinese herbs combined with low dose human menopausal gonadotropin applied in frozen thawed embryo transfer
- 中国结合医学杂志（英文版） 2006年12卷第4期页码：244-249
- Affiliations：
  
  1. Shanghai Medical College of Fudan University,Shanghai,China
  2. Shanghai Institute of Planned Parenthood Research/WHO Collaborating Center for Research in Human Reproduction,China
- Author bio：
- Funds：
  
  Supported by Major State Basic Research Development Program of China (973 Program, No. 2006CB504005) and the National Natural Science Foundation of China (No. 30571968)
- DOI：10.1007/s11655-006-0244-0
  中图分类号：
- 纸质出版日期：2006，
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Zhang, Hq., Zhao, Hx., Gu, Dy. et al. Effect of traditional Chinese herbs combined with low dose human menopausal gonadotropin applied in frozen thawed embryo transfer., Chin. J Integ. Med. 12, 244–249 (2006). https://doi.org/10.1007/s11655-006-0244-0

Zhang Hui-qin, Zhao Hong-xin, Gu Dun-yu, et al. Effect of traditional Chinese herbs combined with low dose human menopausal gonadotropin applied in frozen thawed embryo transfer[J]. Chinese Journal of Integrative Medicine, 2006,12(4):244-249.
Zhang, Hq., Zhao, Hx., Gu, Dy. et al. Effect of traditional Chinese herbs combined with low dose human menopausal gonadotropin applied in frozen thawed embryo transfer., Chin. J Integ. Med. 12, 244–249 (2006). https://doi.org/10.1007/s11655-006-0244-0 DOI：

Zhang Hui-qin, Zhao Hong-xin, Gu Dun-yu, et al. Effect of traditional Chinese herbs combined with low dose human menopausal gonadotropin applied in frozen thawed embryo transfer[J]. Chinese Journal of Integrative Medicine, 2006,12(4):244-249. DOI： 10.1007/s11655-006-0244-0.

摘要

To assess embryo implantation rate (IR) and pregnancy rate (PR) in women who received Bushen Wengong Decoction (??

BSWGD)

a Chinese herbal formula

combined with low dose of human menopausal gonadotropin (hMG) prior to frozen thawed embryo transfer (FET). A total of 262 subjects (674 transferred embryos) who received FET were analyzed retrospectively. In them

122 women were under 30 years old

106 between 30–35 years and 32 over 35 years. The 85 subjects with normal ovulation were assigned to Group A

the natural menstruation cycling group

on whom no pre-transfer treatment was applied. The other 177 subjects with abnormal ovulation were assigned to Group B

and subdivided

according to the pre transfer treatment they received

into three groups

Group B1 (50 cases) received BSWGD

Group B2 (58 cases) received hMG and Group B3 (69 cases) received both BSWGD and low dose hMG. The IR and PR of FET in the four groups were compared

and the effect of the embryo cryo time on PR of FET were compared also. Besides

the influencing factors to FET were analyzed. IR and PR were significantly higher in all age sects of Group B3 than those in Group A

showing significant difference (P < 0.05). IR and PR in subjects in age sects of <30 years and > 35 years in group B3 were significantly higher than those in Group B1 (P < 0.05)

but no significant difference was shown in the two parameters between Group B 2 and Group B3 (P >0.05). PR in the subjects who received embryos with cryo-time of > 200 days was significantly lower than that in those with cryo-time of < 100 days (P <0.05). Embryo cryo-time

endometrial thickness

use of BSWGD and use of hMG were of significance in FET (P < 0.05). A programmed cycle of BSWGD combined with low dose of hMG could improve the embryo IR and PR of FET. Embryo cryo-time

endometrial thickness

and the use of BSWGD and hMG are of significance for FET.

Abstract

To assess embryo implantation rate (IR) and pregnancy rate (PR) in women who received Bushen Wengong Decoction (??

BSWGD)

a Chinese herbal formula

122 women were under 30 years old

106 between 30–35 years and 32 over 35 years. The 85 subjects with normal ovulation were assigned to Group A

the natural menstruation cycling group

on whom no pre-transfer treatment was applied. The other 177 subjects with abnormal ovulation were assigned to Group B

and subdivided

according to the pre transfer treatment they received

into three groups

Group B1 (50 cases) received BSWGD

Group B2 (58 cases) received hMG and Group B3 (69 cases) received both BSWGD and low dose hMG. The IR and PR of FET in the four groups were compared

and the effect of the embryo cryo time on PR of FET were compared also. Besides

the influencing factors to FET were analyzed. IR and PR were significantly higher in all age sects of Group B3 than those in Group A

showing significant difference (P < 0.05). IR and PR in subjects in age sects of <30 years and > 35 years in group B3 were significantly higher than those in Group B1 (P < 0.05)

endometrial thickness

use of BSWGD and use of hMG were of significance in FET (P < 0.05). A programmed cycle of BSWGD combined with low dose of hMG could improve the embryo IR and PR of FET. Embryo cryo-time

endometrial thickness

and the use of BSWGD and hMG are of significance for FET.

关键词

frozen-thawed embryo transferBushen Wengong Decoctionhuman menopausal gonadotropinendometrium

Keywords

frozen-thawed embryo transferBushen Wengong Decoctionhuman menopausal gonadotropinendometrium

references

Li L, Sun XX, Chen JL, et al. Analysis of factors influencing pregnancy rate of frozenthawed embryo transfer. Reprod Contraception 2004; 24(4): 218–221.

Du HZ, Long XL, Shi Y, et al. Analysis of factors influencing clinical outcome of a frozenthawed embryo transfer program. Foreign Med Sci: Maternal Child Health 2005; 16(2): 67–69.

Queenan JT Jr, Veeck LL, Seltman HJ,-et al. Transfer of cryopreserved-thawed preembryos in a natural cycle or a programmed cycle with exogenous hormonal replacement yields similar pregnancy results. Fertil Steril 1994; 62(3): 545–550.

Dong X, Fu W, Xu J. A clinical application human menopausal gonadotropin for improvement of poor response of endometrium undergoing frozen-thawed embryo transfer cycles. J Fudan Univ (Med Sci) 2004; 31(6): 600–602.

Zhang SC, Shen MX, Cai LX, et al. Study on the functions of decoction of invigorating the kidney, regulating menstruation and enriching the blood. J Tradit Chin Med 1999;40(6): 369.

Chen QM, Zhang SC, He B, et al. Study on the effect of Tiaojing Yunyu decoction on promoting competence of endometrium of anovulatory infertility by histomorphologic analysis. Chin Arch Chin Med 2004; 22(3): 464–467.

Steer CV, Mills CL, Tan SL, et al. The cumulative embryo score: a predictive embryo scoring technique to select the optimal number of embryos to transfer in an invitro fertilization and embryo transfer program. Hum Reprod 1992; 7(1): 117–119.

Ma JL, Ma JX, Wang XC, et al. Application and study of Cuyun Pill in IVFET. J Chin Modern Gynecol Obstet 2005; 2(2): 166–167.

Chen QM, Zhang SC, Shen MX. Study on the effect of Tiaojing Yunyu decoction on development of ovarian follicle and endometrium as well as characteristic of blood flow. Chin J Exp TraditMed Formulae 2004; 10(2): 58–61.

Mirkin S, Arslan M, Churikov D, et al. In search of candidate genes critically expressed in the human endometrium during the window of implantation. Hum Reprod 2005; 20(8): 2104–2117.

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