Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites

Tong Guang-dong; Zhou  Da-qiao; He Jin-song; Li Song-lin; Peng Li-sheng

doi:10.1007/s11655-006-0255-4

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Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites

OriginalPaper | Updated：2021-08-27

- Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites
- Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites
- 中国结合医学杂志（英文版） 2006年12卷第4期页码：255-261
- Affiliations：
  
  Department of Hepatology, Shenzhen Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine,China
- Author bio：
- Funds：
  
  Supported by State Administration of TCM (No. 02-03LP40)
- DOI：10.1007/s11655-006-0255-4
  中图分类号：
- 纸质出版日期：2006，
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Tong, Gd., Zhou, Dq., He, Js. et al. Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites., Chin. J Integ. Med. 12, 255–261 (2006). https://doi.org/10.1007/s11655-006-0255-4

Tong Guang-dong, Zhou Da-qiao, He Jin-song, et al. Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites[J]. Chinese Journal of Integrative Medicine, 2006,12(4):255-261.
Tong, Gd., Zhou, Dq., He, Js. et al. Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites., Chin. J Integ. Med. 12, 255–261 (2006). https://doi.org/10.1007/s11655-006-0255-4 DOI：

Tong Guang-dong, Zhou Da-qiao, He Jin-song, et al. Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites[J]. Chinese Journal of Integrative Medicine, 2006,12(4):255-261. DOI： 10.1007/s11655-006-0255-4.

摘要

To explore the influence of Shehuang Paste (麝黄膏

SHP) to the hemodynamics

endotoxin

nitric oxide (NO)

and endothelin-1 (ET-1) in patients with refractory cirrhotic ascites. Fifty-nine cases of refractory cirrhotic ascites were randomly assigned to two groups

32 cases in the treatment group and 27 cases in the control group. The basic treatment was the same for both groups

including liver protecting medicines

diuretics and supportive drugs

but SHP navel sticking was applied for the treatment group additionally once a day. A course of one month of treatment was applied and the general efficacy on ascites was observed by the end of the therapeutic course. Before and after the treatment

examinations by limulus lysate chromogenic test was conducted to measure plasma endotoxin content; colorimetry to measure plasma content of NO indirectly

radioimmunoassay to measure plasma ET-1 content; and color Doppler ultrasonography to measure the blood flow of portal vein and splenic vein. The relationship between the blood flow of portal vein and splenic vein and endotoxin

NO and ET-1 in the treatment group was analyzed as well. The total effective rate on ascites was 84.4% in the treatment group

and 48.1% in the control group

with significant difference shown between them (P<0.01). In the treatment group the blood flow of portal vein and splenic vein

contents of endotoxin

NO and ET-1 all got significantly reduced after treatment (P<0.05 or P<0.01); while these indexes in the control group were not significantly changed (P>0.05). Moreover

it was found that in the treatment group

the blood flow of portal vein and splenic vein had a positive correlation to the levels of NO

ET-1

and endotoxin

either before or after treatment. Application of SHP navel sticking could clearly reduce the blood flow of portal vein and splenic vein

and lower the content of endotoxin

NO and ET-1. The blood flow of portal vein and splenic vein in the treatment group showed a positive correlation with the contents of endotoxin

NO and ET-1.

Abstract

To explore the influence of Shehuang Paste (麝黄膏

SHP) to the hemodynamics

endotoxin

nitric oxide (NO)

and endothelin-1 (ET-1) in patients with refractory cirrhotic ascites. Fifty-nine cases of refractory cirrhotic ascites were randomly assigned to two groups

32 cases in the treatment group and 27 cases in the control group. The basic treatment was the same for both groups

including liver protecting medicines

diuretics and supportive drugs

examinations by limulus lysate chromogenic test was conducted to measure plasma endotoxin content; colorimetry to measure plasma content of NO indirectly

NO and ET-1 in the treatment group was analyzed as well. The total effective rate on ascites was 84.4% in the treatment group

and 48.1% in the control group

with significant difference shown between them (P<0.01). In the treatment group the blood flow of portal vein and splenic vein

contents of endotoxin

NO and ET-1 all got significantly reduced after treatment (P<0.05 or P<0.01); while these indexes in the control group were not significantly changed (P>0.05). Moreover

it was found that in the treatment group

the blood flow of portal vein and splenic vein had a positive correlation to the levels of NO

ET-1

and endotoxin

either before or after treatment. Application of SHP navel sticking could clearly reduce the blood flow of portal vein and splenic vein

and lower the content of endotoxin

NO and ET-1. The blood flow of portal vein and splenic vein in the treatment group showed a positive correlation with the contents of endotoxin

NO and ET-1.

关键词

liver cirrhosisrefractory ascitesvasoactive substancehemodynamics

Keywords

liver cirrhosisrefractory ascitesvasoactive substancehemodynamics

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