Intervention effects of Jianpi Liqi Huoxue Decoction (健脾理气活血汤) on lipid peroxidative liver injury induced by alcohol

Cui Jian-wei; Hu  Yi-yang; Fang Zhi-hong; Wang Xiao-ning; Cheng Yang; Peng Jing-hua; Feng Qin; Zhang Hui

doi:10.1007/s11655-006-0281-0

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Intervention effects of Jianpi Liqi Huoxue Decoction (健脾理气活血汤) on lipid peroxidative liver injury induced by alcohol

OriginalPaper | Updated：2021-08-27

- Intervention effects of Jianpi Liqi Huoxue Decoction (健脾理气活血汤) on lipid peroxidative liver injury induced by alcohol
- Intervention effects of Jianpi Liqi Huoxue Decoction (健脾理气活血汤) on lipid peroxidative liver injury induced by alcohol
- 中国结合医学杂志（英文版） 2006年12卷第4期页码：281-286
- Affiliations：
  
  Institute of Liver Diseases, Shuguang Hospital, Shanghai University of TCM,Shanghai,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No.30371818) and Project of Key Subject Construction of Shanghai (Y0302)
- DOI：10.1007/s11655-006-0281-0
  中图分类号：
- 纸质出版日期：2006，
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Cui, Jw., Hu, Yy., Fang, Zh. et al. Intervention effects of Jianpi Liqi Huoxue Decoction (健脾理气活血汤) on lipid peroxidative liver injury induced by alcohol., Chin. J Integ. Med. 12, 281–286 (2006). https://doi.org/10.1007/s11655-006-0281-0

Cui Jian-wei, Hu Yi-yang, Fang Zhi-hong, et al. Intervention effects of Jianpi Liqi Huoxue Decoction (健脾理气活血汤) on lipid peroxidative liver injury induced by alcohol[J]. Chinese Journal of Integrative Medicine, 2006,12(4):281-286.
Cui, Jw., Hu, Yy., Fang, Zh. et al. Intervention effects of Jianpi Liqi Huoxue Decoction (健脾理气活血汤) on lipid peroxidative liver injury induced by alcohol., Chin. J Integ. Med. 12, 281–286 (2006). https://doi.org/10.1007/s11655-006-0281-0 DOI：

Cui Jian-wei, Hu Yi-yang, Fang Zhi-hong, et al. Intervention effects of Jianpi Liqi Huoxue Decoction (健脾理气活血汤) on lipid peroxidative liver injury induced by alcohol[J]. Chinese Journal of Integrative Medicine, 2006,12(4):281-286. DOI： 10.1007/s11655-006-0281-0.

摘要

To study the intervention effects of Jianpi Liqi Huoxue Decoction (健脾理气活血汤

JLHD) on lipid peroxidative liver injury induced by alcohol. The rat alcoholic model of liver disease (ALD) induced by Lieber DeCarli liquid diet was established. Thirty two male SD rats were randomly divided into 4 groups: the normal group (n=5)

the control group (n=9)

the model group (n=9) and the JLHD group (n=9). From the 4th week after modeling

the rats were given JLHD or distilled water by gastrogavage respectively

and the samples of blood and liver tissues were taken out from the rats for determination by the end of the 8th week. The hepatic pathological changes were observed with HE staining; the liver injury related indices

including activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum

γ-glutamyl transpeptidase (γ-GT) activity and triglyceride (TG) content in liver tissues

as well as the lipid peroxidation related indices

including malonaldehyde (MDA) content and nitric oxide synthase (NOS) activity in liver tissue

serum Fe2+ level

and the anti-peroxidation capacity related indices

including superoxide dismutase (SOD) activity

glutathion (GSH) content and reactive oxygen species (anti ROS) activity in liver tissues were determined. (1) There were obvious figures of fatty degeneration and inflammatory infiltration in liver tissues of the model group. As compared with the control group

in the model group

the activity of ALT and AST

and Fe2+ content in serum

γ-GT and NOS activity

TG and MDA content in liver tissues were significantly higher (P<0.01)

while the activity of SOD

GSH and anti ROS in liver tissues were significantly lower (P<0.01). (2) The fatty degeneration and inflammatory infiltration of liver tissues in the JLHD group were significantly lessen as compared with those in the model group; and the abnormalities of all the indexes revealed in the model rats were restored to certain extent in the JLHD group

and especially significant were the levels of ALT activity

MDA content and Fe2+

which were nearly normal. JLHD has significant effects against alcoholic liver injury

the acting mechanism of which is likely to be related with its anti lipid peroxidative effect.

Abstract

To study the intervention effects of Jianpi Liqi Huoxue Decoction (健脾理气活血汤

the control group (n=9)

the model group (n=9) and the JLHD group (n=9). From the 4th week after modeling

the rats were given JLHD or distilled water by gastrogavage respectively

including activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum

γ-glutamyl transpeptidase (γ-GT) activity and triglyceride (TG) content in liver tissues

as well as the lipid peroxidation related indices

including malonaldehyde (MDA) content and nitric oxide synthase (NOS) activity in liver tissue

serum Fe2+ level

and the anti-peroxidation capacity related indices

including superoxide dismutase (SOD) activity

in the model group

the activity of ALT and AST

and Fe2+ content in serum

γ-GT and NOS activity

TG and MDA content in liver tissues were significantly higher (P<0.01)

while the activity of SOD

and especially significant were the levels of ALT activity

MDA content and Fe2+

which were nearly normal. JLHD has significant effects against alcoholic liver injury

the acting mechanism of which is likely to be related with its anti lipid peroxidative effect.

关键词

Jianpi Liqi Huoxue Decoctionalcoholliver injurylipid peroxidationLieber DeCarli model

Keywords

Jianpi Liqi Huoxue Decoctionalcoholliver injurylipid peroxidationLieber DeCarli model

references

He DY, Hu YY, Xue HM, et al. Clinical study on treatment of fatty liver with Jianpi Huoxue Decoction. Chin J Integr Tradit West Med Dig 2001; 9(1): 35–37.

He DY, Hu YY, Liu P, et al. Effect of Jianpi Huoxue Formula on rats’ hepatic steatosis induced by CCl4 with high fat and low protein diet. Chin J Tradit Med Sci Technol 2001;8(1): 13–14.

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Lieber CS, Jones DP, DeCarli LM. Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J Clin Invest 1965; 44: 1009–1021.

Group of Fatty Liver and Alcoholic Liver Disease, Society of Liver Disease, Chinese Medical Association (CMA). Diagnostic standard on alcoholic liver disease. Chin J Hepatol 2003; 11(2): 72.

de la M Hall P, Lieber CS, DeCarli LM, et al. Models of alcoholic liver disease in rodents: a critical evaluation. Alcohol Clin Exp Res 2001; 25(5 Suppl ISBRA): 254S–261S.

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Yu BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994; 74(1): 139–162.

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