Study on clinical effect and mechanism of Jianpi Qingre Huayu Recipe (健脾清热化瘀方) in treating patients with gastric ulcer

Zhou  Fu-sheng; Hu Li-Juan; Wang Ru-jun; Huang Zhi-xin; Luo Qi

doi:10.1007/s11655-007-0022-z

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Study on clinical effect and mechanism of Jianpi Qingre Huayu Recipe (健脾清热化瘀方) in treating patients with gastric ulcer

OriginalPaper | Updated：2021-08-27

- Study on clinical effect and mechanism of Jianpi Qingre Huayu Recipe (健脾清热化瘀方) in treating patients with gastric ulcer
- Study on clinical effect and mechanism of Jianpi Qingre Huayu Recipe (健脾清热化瘀方) in treating patients with gastric ulcer
- 中国结合医学杂志（英文版） 2007年13卷第1期页码：22-26
- Affiliations：
  
  1. wei Institute of Guangzhou University of Traditional Chinese Medicine, Guangzhou,Pi,China
  2. Guangzhou University of Traditional Chinese Medicine,China
- Author bio：
- Funds：
  
  Supported by Guangdong Provincial Committee of Science and Technology, Project number 6
- DOI：10.1007/s11655-007-0022-z
  中图分类号：
- 纸质出版日期：2007，
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Zhou, Fs., Hu, LJ., Wang, Rj. et al. Study on clinical effect and mechanism of Jianpi Qingre Huayu Recipe (健脾清热化瘀方) in treating patients with gastric ulcer., Chin. J Integ. Med. 13, 22–26 (2007). https://doi.org/10.1007/s11655-007-0022-z

Zhou Fu-sheng, Hu Li-Juan, Wang Ru-jun, et al. Study on clinical effect and mechanism of Jianpi Qingre Huayu Recipe (健脾清热化瘀方) in treating patients with gastric ulcer[J]. Chinese Journal of Integrative Medicine, 2007,13(1):22-26.
Zhou, Fs., Hu, LJ., Wang, Rj. et al. Study on clinical effect and mechanism of Jianpi Qingre Huayu Recipe (健脾清热化瘀方) in treating patients with gastric ulcer., Chin. J Integ. Med. 13, 22–26 (2007). https://doi.org/10.1007/s11655-007-0022-z DOI：

Zhou Fu-sheng, Hu Li-Juan, Wang Ru-jun, et al. Study on clinical effect and mechanism of Jianpi Qingre Huayu Recipe (健脾清热化瘀方) in treating patients with gastric ulcer[J]. Chinese Journal of Integrative Medicine, 2007,13(1):22-26. DOI： 10.1007/s11655-007-0022-z.

摘要

To study the effects of Jianpi Qingre Huayu Recipe (健脾清热化瘀方

JQH) in curing gastric ulcer and to preliminarily probe into its pathogenic mechanism. Fifty patients with gastric ulcer of Pi (脾)-insufficiency and stasis-heat syndrome type were assigned to the treated group (30 patients) and the control group (20 patients). They were treated respectively with JQH and Ranitidine. At the same time

another group consisting of 20 healthy persons was set up for normal control. The clinical effect on gastroscopic figure and traditional Chinese medicine (TCM) syndrome were observed. Changes of T-cell subsets and interleukin-8 (IL-8) in serum as well as IL-8 in mucosa around the gastric ulcer were determined before and after treatment by flow cytometry and ELISA. Comparison of the total effective rate on gastroscopic figure in the treated group and the control group (86.7% vs 80.0%) showed insignificant difference

but the cure rate and markedly effective rate in the former (50.0% and 20.0%) was higher than that in the latter (40.0% and 15.0%) respectively. Comparison of the total effective rate on TCM syndrome in the treated group and in the control group (96.7% vs 70.0%) showed insignificant difference

but the cure rate and markedly effective rate in the former (63.3% and 23.3%) was higher than that in the latter (50.0% and 20.0%) respectively. Serum levels of CD3 +

CD4 +

CD8 + got restored to normal range in the treated group after treatment but it was not so in the control group. IL-8 level in gastric mucosa was improved in both groups but the improvement in the treated group was better. JQH could effectively treat gastric ulcer and partly reduce its recurrence through improving patients’ immune function.

Abstract

To study the effects of Jianpi Qingre Huayu Recipe (健脾清热化瘀方

but the cure rate and markedly effective rate in the former (63.3% and 23.3%) was higher than that in the latter (50.0% and 20.0%) respectively. Serum levels of CD3 +

CD4 +

关键词

Jianpi Qingre Huayu RecipeT-cell subsetsinterleukin-8

Keywords

Jianpi Qingre Huayu RecipeT-cell subsetsinterleukin-8

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