Randomized controlled trial on treatment of bronchial asthma of qi-deficiency cold syndrome type by Pingchuan Yiqi Granule (平喘益气颗粒)

Zhang  Ying; Chang Jing; Chi Huan-hai; Mao Bing; Tang Wen-fu; Wang Lei; Huang Su-zhen; Li Ting-qian; Zhang Rui-ming

doi:10.1007/s11655-007-0027-7

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Randomized controlled trial on treatment of bronchial asthma of qi-deficiency cold syndrome type by Pingchuan Yiqi Granule (平喘益气颗粒)

OriginalPaper | Updated：2021-08-27

- Randomized controlled trial on treatment of bronchial asthma of qi-deficiency cold syndrome type by Pingchuan Yiqi Granule (平喘益气颗粒)
- Randomized controlled trial on treatment of bronchial asthma of qi-deficiency cold syndrome type by Pingchuan Yiqi Granule (平喘益气颗粒)
- 中国结合医学杂志（英文版） 2007年13卷第1期页码：27-32
- Affiliations：
  
  Department of Integrative Chinese and Western Medicine, Huaxi Hospital of Sichuan University,Chengdu,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-007-0027-7
  中图分类号：
- 纸质出版日期：2007，
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Zhang, Y., Chang, J., Chi, Hh. et al. Randomized controlled trial on treatment of bronchial asthma of qi-deficiency cold syndrome type by Pingchuan Yiqi Granule (平喘益气颗粒)., Chin. J Integ. Med. 13, 27–32 (2007). https://doi.org/10.1007/s11655-007-0027-7

Zhang Ying, Chang Jing, Chi Huan-hai, et al. Randomized controlled trial on treatment of bronchial asthma of qi-deficiency cold syndrome type by Pingchuan Yiqi Granule (平喘益气颗粒)[J]. Chinese Journal of Integrative Medicine, 2007,13(1):27-32.
Zhang, Y., Chang, J., Chi, Hh. et al. Randomized controlled trial on treatment of bronchial asthma of qi-deficiency cold syndrome type by Pingchuan Yiqi Granule (平喘益气颗粒)., Chin. J Integ. Med. 13, 27–32 (2007). https://doi.org/10.1007/s11655-007-0027-7 DOI：

Zhang Ying, Chang Jing, Chi Huan-hai, et al. Randomized controlled trial on treatment of bronchial asthma of qi-deficiency cold syndrome type by Pingchuan Yiqi Granule (平喘益气颗粒)[J]. Chinese Journal of Integrative Medicine, 2007,13(1):27-32. DOI： 10.1007/s11655-007-0027-7.

摘要

To evaluate the effect and safety of Pingchuan Yiqi Granule (平喘益气颗粒

PYG) in treating bronchial asthma of qi-deficiency cold syndrome type (BS-QDC). With the randomized

positive agent parallel controlled design adopted

the 80 subjects enrolled were assigned in the ratio of 3:1 to two groups

the 60 patients in the trial group were treated with PYG and the 20 in the control group treated with Ruyi Dingchuan Pill (如意定喘丸

RDP)

with the therapeutic course consisting of 7 days for both groups. The clinical effects

effects on TCM syndrome and the changes of lung function after treatment were observed. The effect of the treatment on asthma in the trial group: clinically controlled rate was 6.67%

markedly effective rate 51.67%

improved rate 33.33% and ineffective rate 8.33%; and the corresponding rates in the control group were 5.00%

50.00%

30.00%

and 15.00% respectively. Comparison between the two groups showed insignificant difference (P>0.05). The effect on TCM syndrome in the treated group: clinically controlled rate was 11.67%

markedly effective rate 58.33%

effective rate 21.67% and ineffective rate 8.33%; and those in the control group were 10.00%

50.00%

30.00% and 10.00% respectively

also showing insignificant difference between the two groups (P>0.05). Lung function test showed that the change on forced expiratory volume in 1 second (FEV1) after treatment in the trial group was of statistical significance (P<0.05)

but no significant difference was shown in the change of peak expiratory flow (PEF

P>0.05); while the changes in the control group were just the opposite

showing insignificance in FEV1 (P>0.05) but significance in PEF (P<0.05). Comparison of the therapeutic effect on lung function between the two groups showed no significant difference (P>0.05). No adverse reaction was found in either group in the course of treatment. PYG used to treat BS-QDC is effective and safe

it’s effect is similar to that of RDP.

Abstract

To evaluate the effect and safety of Pingchuan Yiqi Granule (平喘益气颗粒

PYG) in treating bronchial asthma of qi-deficiency cold syndrome type (BS-QDC). With the randomized

positive agent parallel controlled design adopted

the 80 subjects enrolled were assigned in the ratio of 3:1 to two groups

the 60 patients in the trial group were treated with PYG and the 20 in the control group treated with Ruyi Dingchuan Pill (如意定喘丸

RDP)

with the therapeutic course consisting of 7 days for both groups. The clinical effects

effects on TCM syndrome and the changes of lung function after treatment were observed. The effect of the treatment on asthma in the trial group: clinically controlled rate was 6.67%

markedly effective rate 51.67%

improved rate 33.33% and ineffective rate 8.33%; and the corresponding rates in the control group were 5.00%

50.00%

30.00%

and 15.00% respectively. Comparison between the two groups showed insignificant difference (P>0.05). The effect on TCM syndrome in the treated group: clinically controlled rate was 11.67%

markedly effective rate 58.33%

effective rate 21.67% and ineffective rate 8.33%; and those in the control group were 10.00%

50.00%

30.00% and 10.00% respectively

but no significant difference was shown in the change of peak expiratory flow (PEF

P>0.05); while the changes in the control group were just the opposite

it’s effect is similar to that of RDP.

关键词

Pingchuan Yiqi Granulerandomized controlled trialbronchial asthmaqi-deficiency cold syndrome type

Keywords

Pingchuan Yiqi Granulerandomized controlled trialbronchial asthmaqi-deficiency cold syndrome type

references

Ministry of Health, P.R.C. Principle of guidance on clinical study of TCM new drugs. Vol. 1. 1993: 6–10.

Branch of Respiratory Diseases of the Chinese Association of Medicine. Directory of bronchial asthma prevention and treatment. Chin J Tuberc Respir Dis 1997; 20(5): 261–267.

State Supervisory Administration of Foods and Drugs. Technologic requirement for researches of TCM new drugs. 1999: 34–37.

Ya Ka zu Doumei. Explanation on the recipes used in clinic. Beijing: People’s Medical Publishing House, 1983: 221.

Li BG. Treatment of children asthma with Shenmi Decoction. J Pract Tradit Chin Med 2000;14(1): 45.

Fang D, Kou TQ. Twenty-nine patients of chronic asthmatic bronchitis in acute stage treated mainly with Shenmi Decoction. J Pract Tradit Chin Med 1998;14(3): 11.

Zand LJ. Treatment of chronic cough and asthma with Kampo medicine. Foreign Med Sci (Tradit Chin Med) 2005;27(5): 290–293.

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