Study on effect of Yishen Capsule (益肾胶囊) in preventing recurrence of chronic glomerulonephritis

Wu Xi-li; Sun Wan-sen; Zhang Wang-gang; Qiao Cheng-lin; Ma Qiao-ya; Zhang Xiao-qiang

doi:10.1007/s11655-007-0215-5

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Study on effect of Yishen Capsule (益肾胶囊) in preventing recurrence of chronic glomerulonephritis

OriginalPaper | Updated：2021-08-27

- Study on effect of Yishen Capsule (益肾胶囊) in preventing recurrence of chronic glomerulonephritis
- Study on effect of Yishen Capsule (益肾胶囊) in preventing recurrence of chronic glomerulonephritis
- 中国结合医学杂志（英文版） 2007年13卷第3期页码：215-218
- Affiliations：
  
  1. Department of Integrated Traditional Chinese and Western Medicine, Shaanxi Province Key TCM Department of Nephrology, The Second Affiliated Hospital, Medical School of Xi’an Jiaotong University,Xi’an,China
  2. Department of Hematology, The Second Affiliated Hospital, Medical School of Xi’an Jiaotong University,China
- Author bio：
- Funds：
  
  Supported by Shaanxi Provincial Administration of TCM (No. 2003158)
- DOI：10.1007/s11655-007-0215-5
  中图分类号：
- 纸质出版日期：2007，
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Wu, Xl., Sun, Ws., Zhang, Wg. et al. Study on effect of Yishen Capsule (益肾胶囊) in preventing recurrence of chronic glomerulonephritis., Chin. J. Integr. Med. 13, 215–218 (2007). https://doi.org/10.1007/s11655-007-0215-5

Wu Xi-li, Sun Wan-sen, Zhang Wang-gang, et al. Study on effect of Yishen Capsule (益肾胶囊) in preventing recurrence of chronic glomerulonephritis[J]. Chinese Journal of Integrative Medicine, 2007,13(3):215-218.
Wu, Xl., Sun, Ws., Zhang, Wg. et al. Study on effect of Yishen Capsule (益肾胶囊) in preventing recurrence of chronic glomerulonephritis., Chin. J. Integr. Med. 13, 215–218 (2007). https://doi.org/10.1007/s11655-007-0215-5 DOI：

Wu Xi-li, Sun Wan-sen, Zhang Wang-gang, et al. Study on effect of Yishen Capsule (益肾胶囊) in preventing recurrence of chronic glomerulonephritis[J]. Chinese Journal of Integrative Medicine, 2007,13(3):215-218. DOI： 10.1007/s11655-007-0215-5.

摘要

To observe the effect of Yishen Capsule (益肾胶囊

YSC) on preventing the recurrence of chronic glomerulonephritis (CGN) and to explore its mechanism preliminarily. CGN patients were assigned to the treated group (61 cases) and the control group (48 cases) and all of them were orally administered with 4 mg of Perindopril twice a day

but 3 capsules of YSC

thrice a day

were given additionally to patients in the treated group. The therapeutic course for both groups was 18 months. The recurrence rate of CGN at the 6th

12th

and 18th month in the two groups was observed and compared

and the changes of 24-h urinary protein quantity and T-lymphocyte subsets before and after treatment were observed as well. (1) Comparison of recurrence rate between the two groups showed insignificant difference at the 6th month

but it did show significant difference at the 12th and the 18th month

which was significantly decreased in the treated group than in the control group (P<0.05

P<0.01); (2) The 24-h urinary protein quantity at the 18th month decreased significantly in both groups (P<0.05

P<0.01)

but in the treated group was more significant (P<0.01); (3) T-lymphocyte subsets showed no obvious change in the control group after treatment (P>0.05)

while in the treated group

it showed significant increase in CD3

CD4 and CD4/CD8 (P<0.05 or P<0.01) and significant decrease in CD8 (P<0.05)

and also the difference after treatment in T-lymphocyte subsets between the two groups was significant (P<0.05 or P<0.01). YSC has marked effects in reducing the recurrence of CGN and in decreasing urinary protein

and its mechanism might be related with its function in regulating the ratio of T-lymphocyte subsets to enhance the immunity of patients.

Abstract

To observe the effect of Yishen Capsule (益肾胶囊

but 3 capsules of YSC

thrice a day

were given additionally to patients in the treated group. The therapeutic course for both groups was 18 months. The recurrence rate of CGN at the 6th

12th

and 18th month in the two groups was observed and compared

but it did show significant difference at the 12th and the 18th month

which was significantly decreased in the treated group than in the control group (P<0.05

P<0.01); (2) The 24-h urinary protein quantity at the 18th month decreased significantly in both groups (P<0.05

P<0.01)

but in the treated group was more significant (P<0.01); (3) T-lymphocyte subsets showed no obvious change in the control group after treatment (P>0.05)

while in the treated group

it showed significant increase in CD3

CD4 and CD4/CD8 (P<0.05 or P<0.01) and significant decrease in CD8 (P<0.05)

and its mechanism might be related with its function in regulating the ratio of T-lymphocyte subsets to enhance the immunity of patients.

关键词

Yishen Capsulechronic glomerulonephritisrecurrenceT-lymphocyte subsets

Keywords

Yishen Capsulechronic glomerulonephritisrecurrenceT-lymphocyte subsets

references

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Wu XL, Qiao CL, Sun WS,et al. Effect of Yishen Capsule on proteinuria and NK cells in patients with chronic glomerulonephritis. J Fourth Mlit Med Univ 2003;24(17):1591.

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