Effect of Jin-3-needling therapy on plasma corticosteroid, adrenocorticotrophic hormone and platelet 5-HT levels in patients with generalized anxiety disorder

Yuan Qing; Li Jia-ni; Liu Bin; Wu Zhi-feng; Jin Rui

doi:10.1007/s11655-007-0264-9

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Effect of Jin-3-needling therapy on plasma corticosteroid, adrenocorticotrophic hormone and platelet 5-HT levels in patients with generalized anxiety disorder

OriginalPaper | Updated：2021-08-27

- Effect of Jin-3-needling therapy on plasma corticosteroid, adrenocorticotrophic hormone and platelet 5-HT levels in patients with generalized anxiety disorder
- Effect of Jin-3-needling therapy on plasma corticosteroid, adrenocorticotrophic hormone and platelet 5-HT levels in patients with generalized anxiety disorder
- 中国结合医学杂志（英文版） 2007年13卷第4期页码：264-268
- Affiliations：
  
  1. College of Acupuncture and Massage, Guangzhou Traditional Chinese Medical University,Guangzhou,China
  2. Dongshan Section of the First Affiliated Hospital, Sun Yet-sen University,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-007-0264-9
  中图分类号：
- 纸质出版日期：2007，
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Yuan, Q., Li, Jn., Liu, B. et al. Effect of Jin-3-needling therapy on plasma corticosteroid, adrenocorticotrophic hormone and platelet 5-HT levels in patients with generalized anxiety disorder., Chin. J. Integr. Med. 13, 264–268 (2007). https://doi.org/10.1007/s11655-007-0264-9

Yuan Qing, Li Jia-ni, Liu Bin, et al. Effect of Jin-3-needling therapy on plasma corticosteroid, adrenocorticotrophic hormone and platelet 5-HT levels in patients with generalized anxiety disorder[J]. Chinese Journal of Integrative Medicine, 2007,13(4):264-268.
Yuan, Q., Li, Jn., Liu, B. et al. Effect of Jin-3-needling therapy on plasma corticosteroid, adrenocorticotrophic hormone and platelet 5-HT levels in patients with generalized anxiety disorder., Chin. J. Integr. Med. 13, 264–268 (2007). https://doi.org/10.1007/s11655-007-0264-9 DOI：

Yuan Qing, Li Jia-ni, Liu Bin, et al. Effect of Jin-3-needling therapy on plasma corticosteroid, adrenocorticotrophic hormone and platelet 5-HT levels in patients with generalized anxiety disorder[J]. Chinese Journal of Integrative Medicine, 2007,13(4):264-268. DOI： 10.1007/s11655-007-0264-9.

摘要

To observe the therapeutic efficacy of Jin-3-needling therapy (J3N) on generalized anxiety disorder (GAD) through clinical global impression scale (CGI)

and to explore the mechanism by measuring the plasma levels of corticosteroid (CS)

adrenocorticotrophic hormone (ACTH)

and platelet 5-hydroxytryptamine (5-HT) before and after treatment. Eighty-six GAD patients with the diagnosis agreeing with the inclusion criteria were assigned

according to the sequence of visiting time

to three groups. The 29 patients in the Western medicine group were treated mainly with fluoxetine or paroxetine

Alprazolam might be given additionally in severe conditions if necessary; the 29 patients in the needling group received J3N therapy with Sishenzhen

Dingshenzhen

Neiguan (PC6)

Shenmen (HT7) and Sanyinjiao (SP6) as the chief acupoints selected; and the 28 patients in the combined treatment group were treated with both drugs and needling in the same way as applied in the above two groups. The therapeutic course for all was 6 weeks. Conditions of patients were evaluated before and after treatment with CGI

and levels of CS

ACTH as well as 5-HT were measured by high performance liquid chromatography-electrochemistry. By CGI scoring

the scores of severity index and the general index were not different significantly in the three groups

but the efficacy index proved to be the highest in the needling group

the second in the combined trentment group

and the lowest in the drug group. Plasma level of ACTH and platelet content of 5-HT were lowered in all the three groups after treatment

showing statistical significance (P<0.05)

but no significant change was found in CS level (P>0.05). The therapeutic efficacy of J3N in treating GAD is equivalent to

but with the efficacy index significantly higher than

that of conventional treatment. Moreover

when combined with drugs

needling might effectively prevent the side effect of the routinely used Western drugs. The regulatory action of needling on platelet 5-HT and plasma ACTH is probably one of the acting pathways for J3N treatment on GAD.

Abstract

To observe the therapeutic efficacy of Jin-3-needling therapy (J3N) on generalized anxiety disorder (GAD) through clinical global impression scale (CGI)

and to explore the mechanism by measuring the plasma levels of corticosteroid (CS)

adrenocorticotrophic hormone (ACTH)

and platelet 5-hydroxytryptamine (5-HT) before and after treatment. Eighty-six GAD patients with the diagnosis agreeing with the inclusion criteria were assigned

according to the sequence of visiting time

to three groups. The 29 patients in the Western medicine group were treated mainly with fluoxetine or paroxetine

Alprazolam might be given additionally in severe conditions if necessary; the 29 patients in the needling group received J3N therapy with Sishenzhen

Dingshenzhen

Neiguan (PC6)

and levels of CS

ACTH as well as 5-HT were measured by high performance liquid chromatography-electrochemistry. By CGI scoring

the scores of severity index and the general index were not different significantly in the three groups

but the efficacy index proved to be the highest in the needling group

the second in the combined trentment group

and the lowest in the drug group. Plasma level of ACTH and platelet content of 5-HT were lowered in all the three groups after treatment

showing statistical significance (P<0.05)

but no significant change was found in CS level (P>0.05). The therapeutic efficacy of J3N in treating GAD is equivalent to

but with the efficacy index significantly higher than

that of conventional treatment. Moreover

when combined with drugs

关键词

Jin-3-needlinganxiety neurosisClinical Studyacting mechanism

Keywords

Jin-3-needlinganxiety neurosisClinical Studyacting mechanism

references

Shen YC, ed. Psychiatry. 4th ed. Beijing: People’s Medical Publishing House, 2003:460.

Xu TY, ed. Contemporary psychiatry. Shanghai: Shanghai Medical University Publishing House, 2000:339–341.

Liu YP. Cost-effectiveness analysis of 4 regimens in treating generalized anxiety disorder. J Tianjin Med Univ (Chin) 2006;12(1):129–130.

Hai RH, Chen XZ, Jing J. Effects of electroacupuncture on personality and behavior pattern of the patient with generalized anxiety disorder. Chin Acupunct Moxibust (Chin) 2004;24(3):165–166.

Zhang MY, ed. Handbook of psychiatry rating scale. Changsha: Hunan Science and Technological Publishing House, 1998:101.

Zhang YL, Zhao JP, Yang DS, et al. A longitudinal study of monoamine neurotransmitters, neuroendocrine and immune parameter in the patients with generalized anxiety disorder. Chin J Physician (Chin) 2000;33(4):200–202.

Gerra G, Zaimovic A, Zambelli U, et al. Neuroendocrine responses to psychological stress in adolescents with anxiety disorder. Neuropsychobiology 2000;42:82–85.

Tiller JW, Biddle N, Maguive KP, et al. The dexamethasone supression test and plasma dexamethasone in generalized anxiety disorder. Biol Psychiatry 1988;23(3):261–270.

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