Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus

Fu-rong Lu; Lin Shen; You Qin; Lan Gao; Heng Li; Yi Dai

doi:10.1007/s11655-007-9005-3

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Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus

OriginalPaper | Updated：2021-08-27

- Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus
- Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus
- 中国结合医学杂志（英文版） 2008年14卷第1期页码：56-60
- Affiliations：
  
  Department of Integrated Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-007-9005-3
  中图分类号：
- 纸质出版日期：2008，
  
  网络出版日期：2008-6-21，
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Lu, Fr., Shen, L., Qin, Y. et al. Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus., Chin. J. Integr. Med. 14, 56–60 (2008). https://doi.org/10.1007/s11655-007-9005-3

Fu-rong Lu, Lin Shen, You Qin, et al. Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus[J]. Chinese Journal of Integrative Medicine, 2008,14(1):56-60.
Lu, Fr., Shen, L., Qin, Y. et al. Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus., Chin. J. Integr. Med. 14, 56–60 (2008). https://doi.org/10.1007/s11655-007-9005-3 DOI：

Fu-rong Lu, Lin Shen, You Qin, et al. Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus[J]. Chinese Journal of Integrative Medicine, 2008,14(1):56-60. DOI： 10.1007/s11655-007-9005-3.

摘要

To evaluate the efficacy and safety of trigonella foenum-graecum L. total saponins (TFGs) in combination with sulfonylureas (SU) in the treatment of patients with type 2 diabetes mellitus (T2DM) not well controlled by SU alone. Sixty-nine T2DM patients whose blood glucose levels were not well controlled by oral sulfonylureas hypoglycemic drug were randomly assigned to the treated group (46 cases) and the control group (23 cases)

and were given TFGs or placebo three times per day

6 pills each time for 12 weeks

respectively. Meanwhile

the patients continued taking their original hypoglycemic drugs. The following indexes

including effects on traditional Chinese medicine (TCM) symptoms

fast blood glucose (FBG)

2-h post-prandial blood glucose (2h PBG)

glycosylated hemoglobin (HbA1c)

clinical symptomatic quantitative scores (CSQS)

body mass index (BMI)

as well as hepatic and renal functions

were observed and compared before and after treatment. The efficacy on TCM symptoms was obviously better in the treated group than that in the control group (P<0.01)

and there were statistically remarkable decreases in aspect of FBG

2h PBG

HbA1c and CSQS in the treated group as compared to those in the control group (P<0.05 or P<0.01)

while no signifiClassifi cationcant difference was found in BMI

hepatic and renal functions between the two groups (P>0.05). The combined therapy of TFGs with sulfonylureas hypoglycemic drug could lower the blood glucose level and ameliorate clinical symptoms in the treatment of T2DM

and the therapy was relatively safe.

Abstract

and were given TFGs or placebo three times per day

6 pills each time for 12 weeks

respectively. Meanwhile

the patients continued taking their original hypoglycemic drugs. The following indexes

including effects on traditional Chinese medicine (TCM) symptoms

fast blood glucose (FBG)

2-h post-prandial blood glucose (2h PBG)

glycosylated hemoglobin (HbA1c)

clinical symptomatic quantitative scores (CSQS)

body mass index (BMI)

as well as hepatic and renal functions

were observed and compared before and after treatment. The efficacy on TCM symptoms was obviously better in the treated group than that in the control group (P<0.01)

and there were statistically remarkable decreases in aspect of FBG

2h PBG

HbA1c and CSQS in the treated group as compared to those in the control group (P<0.05 or P<0.01)

while no signifiClassifi cationcant difference was found in BMI

and the therapy was relatively safe.

关键词

trigonella foenum-graecum L.type 2 diabetes mellitussulfonylureas

Keywords

trigonella foenum-graecum L.type 2 diabetes mellitussulfonylureas

references

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Preet A, Siddiqui MR, Taha A, et al. Long-term effect of Trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biothemical abnormalities in diabetic rat ocular tissues. Mol Cell Biochem 2006;289:137–147.

Thakran S, Siddiqui MR, Baquer NZ. Trigonella foenum graecum seed powder protects against pathological abnormalities in tissues of diabetic rats. Mol Cell Biochem 2004;266:151–159.

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