Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus

Xiao-juan Tao; Hong-xia Zheng; Jian-ning Yu; Ji-lin Ma; Wen Zhang

doi:10.1007/s11655-008-0180-7

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Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus

OriginalPaper | Updated：2021-08-27

- Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus
- Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus
- 中国结合医学杂志（英文版） 2008年14卷第3期页码：180-184
- Affiliations：
  
  Department of Rheumatology and Immunology, Hospital of Integrative Chinese and Western Medicine,Hangzhou,China
- Author bio：
- Funds：
  
  Supported by the Funds of Hangzhou Municipal Medical Key Subjects (No. 2005633Q14)
- DOI：10.1007/s11655-008-0180-7
  中图分类号：
- 纸质出版日期：2008，
  
  网络出版日期：2008-10-14，
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Tao, Xj., Zheng, Hx., Yu, Jn. et al. Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus., Chin. J. Integr. Med. 14, 180–184 (2008). https://doi.org/10.1007/s11655-008-0180-7

Xiao-juan Tao, Hong-xia Zheng, Jian-ning Yu, et al. Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus[J]. Chinese Journal of Integrative Medicine, 2008,14(3):180-184.
Tao, Xj., Zheng, Hx., Yu, Jn. et al. Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus., Chin. J. Integr. Med. 14, 180–184 (2008). https://doi.org/10.1007/s11655-008-0180-7 DOI：

Xiao-juan Tao, Hong-xia Zheng, Jian-ning Yu, et al. Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus[J]. Chinese Journal of Integrative Medicine, 2008,14(3):180-184. DOI： 10.1007/s11655-008-0180-7.

摘要

To study the principle of clearing Fei (肺)

cooling blood

and detoxification as well as nourishing yin and moisening Fei (abbr. as CCD-NM) in regulating the levels of peripheral T-lymphocyte subsets Th and Tc cells to explore its mechanism for lowering the incidence of infection in patients with systemic lupus erythematosus (SLE). Sixty SLE patients without complicated infection were assigned to the treatment group and the control group

30 in each group. The control group was treated with Western medicine alone

while the treatment group was treated with the same program of Western medicine

but additionally administered with either Langchuang No.1 (狼疮I号) or 2 (狼疮II号)

serial concerted Chinese recipes

applied respectively in patients in the active stage or in the resting stage. The total time of treatment for both groups was 1 year. Further

a healthy control group was set up with 20 healthy subjects. The expressions of Th1

Th2

and Tc1 and Tc2 cells in peripheral blood were detected and compared with those in the healthy control group. (1) As compared with the healthy control group

ratios of Th1/Th2 and Tc1/Tc2 in SLE patients

whether complicated with infection or not

were significantly lower (P<0.05 or P<0.01). (2) Comparison between patients with complications and those uncomplicated with infection showed that the two ratios and Th1 expression were lower and Tc2 was higher in the former than those in the latter (all P<0.05). (3) Ratios of Th1/Th2 and Tc1/Tc2 increased after treatment in patients of both the treatment group and the control group (P<0.05 and P<0.01)

but the changes in the treatment group were more significant (P<0.05). The principle of CCD-NM could regulate the Th and Tc subsets toward equilibrium in SLE patients

which might be one of the mechanisms of action for alleviating complicated infection.

Abstract

To study the principle of clearing Fei (肺)

cooling blood

30 in each group. The control group was treated with Western medicine alone

while the treatment group was treated with the same program of Western medicine

but additionally administered with either Langchuang No.1 (狼疮I号) or 2 (狼疮II号)

serial concerted Chinese recipes

applied respectively in patients in the active stage or in the resting stage. The total time of treatment for both groups was 1 year. Further

a healthy control group was set up with 20 healthy subjects. The expressions of Th1

Th2

and Tc1 and Tc2 cells in peripheral blood were detected and compared with those in the healthy control group. (1) As compared with the healthy control group

ratios of Th1/Th2 and Tc1/Tc2 in SLE patients

whether complicated with infection or not

but the changes in the treatment group were more significant (P<0.05). The principle of CCD-NM could regulate the Th and Tc subsets toward equilibrium in SLE patients

which might be one of the mechanisms of action for alleviating complicated infection.

关键词

Langchuang No.1Langchuang No.2systemic lupus erythematosusinfectionTh and Tc subsets of T-lymphocyte

Keywords

Langchuang No.1Langchuang No.2systemic lupus erythematosusinfectionTh and Tc subsets of T-lymphocyte

references

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Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus (SLE). Arthritis Rheum 1982;25:1271–1277.

Hay E, Cordon C, Emery P, et al. Assessment of lupus. Where are we now? Ann Rheum Dis 1993;52:169–172.

Varadhachary AS, Peter ME, Perdow SN, et al. Seletive up-regulation of phosphatidylinositol 3′-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 resistance from Fasmediated apoptosis. J Immunol 1999;163:4772–4779.

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Xu G, Liu ML, Yu KM. A prospective study of nosocomial infection in patients with systemic lupus erythematosus. Chin J Rheumatol (Chin) 2003;7(4):216–219.

Xu G, Xu Q, Yu LM. An analysis of nosocomial infection in patients with systemic lupus erythematosus. Chin J Nosocomiol (Chin) 2000;10(5):362–364.

Yu Y, Chen J, Xie FA, et al. Clinical investigation of nosocomial infection cases with lupus nephritis. Chin J Nosocomiol (Chin) 2000;10(3):174–176.

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