Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism

Jun Feng; Zhi Zheng

doi:10.1007/s11655-008-0197-y

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Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism

OriginalPaper | Updated：2021-08-27

- Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism
- Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism
- 中国结合医学杂志（英文版） 2008年14卷第3期页码：197-201
- Affiliations：
  
  Department of Emergency Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology,Wuhan,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30500657)
- DOI：10.1007/s11655-008-0197-y
  中图分类号：
- 纸质出版日期：2008，
  
  网络出版日期：2008-10-14，
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Feng, J., Zheng, Z. Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism., Chin. J. Integr. Med. 14, 197–201 (2008). https://doi.org/10.1007/s11655-008-0197-y

Jun Feng, Zhi Zheng. Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism[J]. Chinese Journal of Integrative Medicine, 2008,14(3):197-201.
Feng, J., Zheng, Z. Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism., Chin. J. Integr. Med. 14, 197–201 (2008). https://doi.org/10.1007/s11655-008-0197-y DOI：

Jun Feng, Zhi Zheng. Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism[J]. Chinese Journal of Integrative Medicine, 2008,14(3):197-201. DOI： 10.1007/s11655-008-0197-y.

摘要

To investigate the effects of sodium tanshinone II A sulfonate (STS) on the hypertrophy induced by angiotensin II (Ang II) in primary cultured neonatal rat cardiac myocytes. The effect of STS on cytotoxicity was evaluated using the 3-(4

5-dimethylthiazol-2-yl)-3

5-phenytetrazoliumromide (MTT) assay. As indexes for cardiocyte hypertrophy

cell size was determined by phase contrast microscopy and protein synthesis rate was measured by 3H-leucine incorporation. The proto-oncogene c-fos mRNA expression of cardiocytes was assessed using reverse transcription polymerase chain reaction (RT-PCR). STS could inhibit cardiocyte hypertrophy

increase the protein synthesis rate and enhance proto-oncogene c-fos mRNA expression in cardiocytes induced by Ang II (P<0.01)

with an effect similar to that of Valsartan

the Ang II receptor antagonist. STS can prevent the hypertrophy of cardiac myocytes induced by Ang II

which may be related to its inhibition of the expression of proto-oncogene c-fos mRNA.

Abstract

5-dimethylthiazol-2-yl)-3

5-phenytetrazoliumromide (MTT) assay. As indexes for cardiocyte hypertrophy

increase the protein synthesis rate and enhance proto-oncogene c-fos mRNA expression in cardiocytes induced by Ang II (P<0.01)

with an effect similar to that of Valsartan

the Ang II receptor antagonist. STS can prevent the hypertrophy of cardiac myocytes induced by Ang II

which may be related to its inhibition of the expression of proto-oncogene c-fos mRNA.

关键词

sodium tanshinone II A sulfonateangiotensin IIcardiac myocyte hypertrophyc-fos

Keywords

sodium tanshinone II A sulfonateangiotensin IIcardiac myocyte hypertrophyc-fos

references

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