Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice

Yan-ling Zhao; Jia-bo Wang; Li-mei Shan; Cheng Jin; Li Ma; Xiao-he Xiao

doi:10.1007/s11655-008-0207-2

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Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice

OriginalPaper | Updated：2021-08-27

- Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice
- Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice
- 中国结合医学杂志（英文版） 2008年14卷第3期页码：207-211
- Affiliations：
  
  Institute of Traditional Chinese Material Medica, the Hospital of PLA,Beijing,China,302
- Author bio：
- Funds：
  
  Supported by Foundation of State Administration of Traditional Chinese Medicine (No. 04-05ZP970) and Military 11th Five-Year Foundation (No. 06MA360)
- DOI：10.1007/s11655-008-0207-2
  中图分类号：
- 纸质出版日期：2008，
  
  网络出版日期：2008-10-14，
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Zhao, Yl., Wang, Jb., Shan, Lm. et al. Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice., Chin. J. Integr. Med. 14, 207–211 (2008). https://doi.org/10.1007/s11655-008-0207-2

Yan-ling Zhao, Jia-bo Wang, Li-mei Shan, et al. Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice[J]. Chinese Journal of Integrative Medicine, 2008,14(3):207-211.
Zhao, Yl., Wang, Jb., Shan, Lm. et al. Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice., Chin. J. Integr. Med. 14, 207–211 (2008). https://doi.org/10.1007/s11655-008-0207-2 DOI：

Yan-ling Zhao, Jia-bo Wang, Li-mei Shan, et al. Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice[J]. Chinese Journal of Integrative Medicine, 2008,14(3):207-211. DOI： 10.1007/s11655-008-0207-2.

摘要

To investigate the effect of Radix Isatidis polysaccharides (RIP) on the immunological function and expression of immune related cytokines in mice. Sixty mice were randomly divided into six groups

the normal group

cyclophosphamide (Cy) model group

Levamisole (positive control) group

RIP low

medium and high dose groups (0.08 g/kg

0.16 g/kg

0.32 g/kg

respectively)

ten in each group. By detecting the value of abdominal macrophage phagocytic index

serum hemolysin (HC50)

proliferation of lymphocytes and expression of related cytokines

interleukin (IL-2) and interferon γ (INF-γ)

the effect of RIP on immunological function and its mechanism were studied. RIP could improve the level of hemolysin in immunological function depressed mice. The results showed that the value of macrophage phagocytic index in the high dose RIP group increased from 1.11±0.13 to 1.42±0.26. The level of IL-2 and INF-γ could be decreased by Cy to 38.12±6.88 ng/L and 139.23±29.87 ng/L

respectively

while RIP in high dose could increase the secretion of IL-2 and INF-γ to 53.54±14.43 ng/L and 189.91±32.63 ng/L

respectively. RIP could enhance non-specific immunological function

humoral immunity and cellular immunity in mice.

Abstract

To investigate the effect of Radix Isatidis polysaccharides (RIP) on the immunological function and expression of immune related cytokines in mice. Sixty mice were randomly divided into six groups

the normal group

cyclophosphamide (Cy) model group

Levamisole (positive control) group

RIP low

medium and high dose groups (0.08 g/kg

0.16 g/kg

0.32 g/kg

respectively)

ten in each group. By detecting the value of abdominal macrophage phagocytic index

serum hemolysin (HC50)

proliferation of lymphocytes and expression of related cytokines

interleukin (IL-2) and interferon γ (INF-γ)

respectively

while RIP in high dose could increase the secretion of IL-2 and INF-γ to 53.54±14.43 ng/L and 189.91±32.63 ng/L

respectively. RIP could enhance non-specific immunological function

humoral immunity and cellular immunity in mice.

关键词

Radix Isatidis polysaccharidesmacrophageserum hemolysinlymphocytecytokine

Keywords

Radix Isatidis polysaccharidesmacrophageserum hemolysinlymphocytecytokine

references

Wu XY, Liu YH, Sheng WY, et al. Chemical constituents of isatis indigotica. Planta Medica 1997;63(1):55–57.

Yin J, Guo LG. Modern research and clinical application of traditional Chinese medicine. Beijing: Academy Press, 1995:52–57.

Ma L, Feng SH, Tang JY, et al. Influence of Radix Isatidis polysaccharides produced by different preparation technologies on proliferation function of mouse splenic lymphocytes. China Pharm (Chin) 2007; 18(3): 169–171.

Wu XL, Cai YQ, Zhao Y, Li SF. Effects of extract from taraxacum monogon (ETM) on immune modulation in mice. Acta Univ Med Nanjing (Natural Sci, Chin) 2005; 25(3):163–165.

Liu J, Gao M, Yu H, et al. Effect of wild lactarius volemus from Guizhou province on immune function in mice. Chin J Public Health (Chin) 2007;23(3): 291–293.

Kim HM, Han SB, Oh GT, et al. Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom phellinus Linteus. Int J Immunopharmacol 1996;18:295–303.

Sherwood ER, Wiliams DL, McNamee RB, et al. Enhancement of interleukin 1 and interleukin 2 production by soluble glucan. Int J Immunopharmacol 1987; 9:261–267.

Estrada A, Yun CH, Van Kessel A, et al. Immunomodulatory activities of oat beta-glucan in vitro and in vitro. Microbiol Immunol 1997;42:991–998.

Bin-Hafeez B, Haque R, Parvez S, et al. Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. Int Immunopharmacol 2003;3:257–265.

Gong FL, ed. Medical immunology. 2nd ed. Beijing: Science Press, 2004:171–174.

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