Cohort study on the effect of a combined treatment of traditional Chinese medicine and Western medicine on the relapse and metastasis of 222 patients with stage II and III colorectal cancer after radical operation

Yu-fei Yang; Jian-zhong Ge; Yu Wu; Yun Xu; Bi-yan Liang; Lin Luo; Xian-wen Wu; Duan-qi Liu; Xia Zhang; Fei-xiang Song; Zhen-ying Geng

doi:10.1007/s11655-008-0251-9

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Cohort study on the effect of a combined treatment of traditional Chinese medicine and Western medicine on the relapse and metastasis of 222 patients with stage II and III colorectal cancer after radical operation

OriginalPaper | Updated：2021-08-27

- Cohort study on the effect of a combined treatment of traditional Chinese medicine and Western medicine on the relapse and metastasis of 222 patients with stage II and III colorectal cancer after radical operation
- Cohort study on the effect of a combined treatment of traditional Chinese medicine and Western medicine on the relapse and metastasis of 222 patients with stage II and III colorectal cancer after radical operation
- 中国结合医学杂志（英文版） 2008年14卷第4期页码：251-256
- Affiliations：
  
  1. Department of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  2. Department of Oncology, General Hospital of Beijing Military Area,Beijing,China
- Author bio：
- Funds：
  
  Supported by Norway National Evidence Based Medicine to Provide Financial Assistance Project (No. 0221)
- DOI：10.1007/s11655-008-0251-9
  中图分类号：
- 纸质出版日期：2008，
  
  网络出版日期：2008-12-12，
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Yang, Yf., Ge, Jz., Wu, Y. et al. Cohort study on the effect of a combined treatment of traditional Chinese medicine and Western medicine on the relapse and metastasis of 222 patients with stage II and III colorectal cancer after radical operation., Chin. J. Integr. Med. 14, 251–256 (2008). https://doi.org/10.1007/s11655-008-0251-9

Yu-fei Yang, Jian-zhong Ge, Yu Wu, et al. Cohort study on the effect of a combined treatment of traditional Chinese medicine and Western medicine on the relapse and metastasis of 222 patients with stage II and III colorectal cancer after radical operation[J]. Chinese Journal of Integrative Medicine, 2008,14(4):251-256.
Yang, Yf., Ge, Jz., Wu, Y. et al. Cohort study on the effect of a combined treatment of traditional Chinese medicine and Western medicine on the relapse and metastasis of 222 patients with stage II and III colorectal cancer after radical operation., Chin. J. Integr. Med. 14, 251–256 (2008). https://doi.org/10.1007/s11655-008-0251-9 DOI：

Yu-fei Yang, Jian-zhong Ge, Yu Wu, et al. Cohort study on the effect of a combined treatment of traditional Chinese medicine and Western medicine on the relapse and metastasis of 222 patients with stage II and III colorectal cancer after radical operation[J]. Chinese Journal of Integrative Medicine, 2008,14(4):251-256. DOI： 10.1007/s11655-008-0251-9.

摘要

To evaluate the effectiveness of a comprehensive therapy of traditional Chinese medicine (TCM) in reducing the relapse and metastasis of stage II and III colorectal cancer based on conventional Western medicine (WM) therapy. Two hundred and twenty-two patients in total

diagnosed as stage II and III colorectal cancer from February 2000 to March 2006

were recruited from Xiyuan Hospital

China Academy of Chinese Medical Sciences and the General Hospital of Beijing Military Area. They were followed-up once every 3–6 months. Twenty cases dropped out from the cohort. The remaining 202 patients were all treated with routine WM treatment [including R0 radical operation

or chemotherapy or/and radiotherapy according to national comprehensive cancer network (NCCN) clinical guidelines]. These patients were assigned to two groups based on whether or not they were additionally treated with TCM comprehensive therapy (orally administered with a decoction according to syndrome differentiation

combined with a traditional patent drug over one year). Ninety-eight patients from Xiyuan Hospital were treated with WM and TCM (combined group)

and 104 patients from the General Hospital of Beijing Military Area were treated with WM alone (WM group). The demographic data at baseline were comparable

including the operation times

age

sex

TNM staging

and pathological types. The patients were followed-up for one to five years. Up to now

there are 98

and 47 patients with 1

and 5 years of follow-up in the combined group

respectively; and 104

104

and 55 patients in the WM group

respectively. The results of the 5-year follow-up of all the patients will be available in 2011. The relapse/metastasis rate of 1-

and 5-year were 0 (0/98)

2.04% (2/98)

11.69% (9/77)

14.06% (9/64)

and 21.28% (10/47) in the combined group

and were 4.80%(5/104)

16.35% (17/104)

21.65% (21/97)

25.93% (21/81)

and 38.18%(21/55) in the WM group

respectively. A significant difference was found in the second year between the two groups (χ 2=12.117

P=0.000). Median relapse/metastasis time was 26.5 months in the combined group and 16.0 months in the WM group. The combined therapy of TCM and WM may have great clinical value and a potential for decreasing the relapse or metastasis rate in stage II and III colorectal cancer after conventional WM therapy.

Abstract

diagnosed as stage II and III colorectal cancer from February 2000 to March 2006

were recruited from Xiyuan Hospital

combined with a traditional patent drug over one year). Ninety-eight patients from Xiyuan Hospital were treated with WM and TCM (combined group)

and 104 patients from the General Hospital of Beijing Military Area were treated with WM alone (WM group). The demographic data at baseline were comparable

including the operation times

age

sex

TNM staging

and pathological types. The patients were followed-up for one to five years. Up to now

there are 98

and 47 patients with 1

and 5 years of follow-up in the combined group

respectively; and 104

104

and 55 patients in the WM group

respectively. The results of the 5-year follow-up of all the patients will be available in 2011. The relapse/metastasis rate of 1-

and 5-year were 0 (0/98)

2.04% (2/98)

11.69% (9/77)

14.06% (9/64)

and 21.28% (10/47) in the combined group

and were 4.80%(5/104)

16.35% (17/104)

21.65% (21/97)

25.93% (21/81)

and 38.18%(21/55) in the WM group

respectively. A significant difference was found in the second year between the two groups (χ 2=12.117

关键词

combined therapy of traditional Chinese medicineconventional Western medicine therapycolorectal cancerrelapse and metastasiscohort study

Keywords

combined therapy of traditional Chinese medicineconventional Western medicine therapycolorectal cancerrelapse and metastasiscohort study

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