Progress in research on the anti-tumor effect of artesunate

Rong-rong He; Huai-jun Zhou

doi:10.1007/s11655-008-0312-0

Your Location：

Home >

Browse articles >

Progress in research on the anti-tumor effect of artesunate

ReviewPaper | Updated：2021-08-27

- Progress in research on the anti-tumor effect of artesunate
- Progress in research on the anti-tumor effect of artesunate
- 中国结合医学杂志（英文版） 2008年14卷第4期页码：312-316
- Affiliations：
  
  1. Gulou Medical College of Integrative Chinese and Western Medicine, The No.1 Clinical Medical College, Nanjing University of Chinese Medicine,Nanjing,China
  2. Department of Gynecology and Obstetrics, Nanjing Drum Tower Hospital,Nanjing,China
- Author bio：
- Funds：
  
  Supported by Social Development Plan for Research and Development Projects of Jiangsu Province (BS2004007)
- DOI：10.1007/s11655-008-0312-0
  中图分类号：
- 纸质出版日期：2008，
  
  网络出版日期：2008-12-12，
Scan for full text
He, Rr., Zhou, Hj. Progress in research on the anti-tumor effect of artesunate., Chin. J. Integr. Med. 14, 312–316 (2008). https://doi.org/10.1007/s11655-008-0312-0

Rong-rong He, Huai-jun Zhou. Progress in research on the anti-tumor effect of artesunate[J]. Chinese Journal of Integrative Medicine, 2008,14(4):312-316.
He, Rr., Zhou, Hj. Progress in research on the anti-tumor effect of artesunate., Chin. J. Integr. Med. 14, 312–316 (2008). https://doi.org/10.1007/s11655-008-0312-0 DOI：

Rong-rong He, Huai-jun Zhou. Progress in research on the anti-tumor effect of artesunate[J]. Chinese Journal of Integrative Medicine, 2008,14(4):312-316. DOI： 10.1007/s11655-008-0312-0.

摘要

It has been found in recent years that Artesunate (Art)

a water soluble derivative of arteannuin

mainly previously used for its anti-malarial activity

has some other effects

e.g. it could act as an anti-tumor agent by way of inducing cell apoptosis

antagonizing angiogenesis

reversing immunosuppression of tumor cells

etc. More and more attention is being paid to the anti-tumor effects of Art. Such progress is reviewed in this paper.

Abstract

It has been found in recent years that Artesunate (Art)

a water soluble derivative of arteannuin

mainly previously used for its anti-malarial activity

has some other effects

e.g. it could act as an anti-tumor agent by way of inducing cell apoptosis

antagonizing angiogenesis

reversing immunosuppression of tumor cells

etc. More and more attention is being paid to the anti-tumor effects of Art. Such progress is reviewed in this paper.

关键词

Artesunatetumorcell apoptosisangiogenesis

Keywords

Artesunatetumorcell apoptosisangiogenesis

references

Yang CP, Wan HJ. Research progress in antitoxoplasmic effect of artemisinin and its derivatives. Int J Med Parasit Dis (Chin) 2006;33(3):160–162.

Ye QX, Lu X. Research progress in antitumor of artemisinin and derivatives. J Pract Med (Chin) 2006;22(5):600–601.

Efferth T, Dunstan H, Sauerbrey A, et al. The anti-malarial artesunate is also active against cancer. Int J Oncol 2001;18(4): 767–773.

Liu X, Li Y, Xu GL, et al. Effects of artesunate on K562 cell apoptosis and Fas/FasL expression of chronic granulocytic leukemia. Shanghai J Tradit Chin Med (Chin) 2006;40(10):63–65.

Li PC, Lam E, Roos WP, et al. Artesunate derived from traditional Chinese medicine induces DNA damage and repair. Cancer Res 2008;68:4347–4351.

Li LN, Zhang HD, Yuan SJ, et al. Artesunate attenuates the growth of human colorectal carcinoma and inhibits hyperactive Wnt/beta-catenin pathway. Int Cancer 2007;121:1360–1365.

Zhang YC, Yu SH, Zhang YH, et al. Percutaneous transhepatic injection of artesunate by ultrasonic guidance in treating primary hepatic carcinoma 15 cases. J Clin Med Pract (Chin) 2007;11(3):64–67.

Zhang ZY, Yu SQ, Miao LY, et al. Artesunate combined with vinorelbine plus cisplatin in treatment of advanced nonsmall cell lung cancer: A randomized controlled trial. J Chin Integr Med (Chin) 2008;6(2):134–138.

Chen LJ, Jin QY, Yu LR, et al. Research progress on antitumor of artemisinin and derivatives. Chin Tradit Herb Drugs (Chin) 2005;36(11):1754–1755.

Wang J, Liu L, Li JM, et al. The inhibitory effect of artesunate on human esophageal carcinoma is associated with modulation of CDC25A and TGFβ. Tumor (Chin) 2007;27(4):272–276.

Zhang X, Yang XP, Pan QC. Studies on the antitumor effect and apoptosis induction in human liver cancer cell line (BEL-7402) by sodium artesunate. Chin Tradit Herb Drugs (Chin) 1998;29(7):467–469.

Li Z, Yuan SJ, Nie LP, et al. Apoptosis of tumor cells induced by artesunate is associated with suppressing survivin expression. Chin J Clin Pharmacol Ther (Chin) 2004;9(6):607–611.

Wu LM, Zhao Y, Wang Q, et al. Preliminary mechanism of artesunate treating hepatocarcinoma. China J Basic Med Tradit Chin Med (Chin) 2002;8(8):33–34.

Zhang YC, Chen SY, Zhang YL. Effects of artemisunate on expression of intercellular adhesion molecule-1 in human colon cancer line HCT116. Chin J Clin Med (Chin) 2006;13(5):775–776.

Ai JX. Inhibiting effect of artemisinin on Hela cell growth. J Shanxi Med Univ (Chin) 2007;38(3):204–207.

Efferth T, Giaisi M, Merling A, et al. Artesunate induce ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells. PLoS ONE 2007;2(1):e693.

Wang YY, Song XF, Cui XJ, et al. Apoptosis induced by artesunate in human adenocarcinoma cell line A549 cells associated with activation of caspase-9 and caspase-3. Cancer Res Prev Treat 2007;34(9):651–653.

Kelter G, Steinbach D, Konkimalla VB, et al. Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate. PLoS ONE 2007;2(8):e798.

Wang WQ, Zhou HJ, Chen HH, et al. Inhibitory effect of artesunate on angiogenesis. Chin J Pharmacol Toxicol (Chin) 2004;18(1):32–36.

Chen HH, Zhou H J, Wu GD, et al. Inhibitory effects of artesunate on angiogenesis and on expressions of vascular endothelial growth factor and VEGF receptor KDR / flk-1. Pharmacology 2004;71(1):1–9.

Zhou HJ, Wang WQ, Wu GD, et al. Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells. Vascul Pharmacol 2007;47(2–3):131–138.

Lee J, Zhou HJ, Wu XH. Dihydroartemisinin downregulates vascular endothelial growth factor expression and induces apoptosis in chronic myeloid leukemia K562 cells. Cancer Chemother Pharmacol 2006;57:213–220.

Dell’ Eva R, Pfeffer U, Vene R, et al. Inhibition of angiogenesis in vivo and growth of Kaposi’s sarcoma xenograft tumors by the anti-malarial artesunate. Biochem Pharmacol 2004;68:2359–2366.

Lewis MP, Lygoe KA, Nystrom ML, et al. Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells. Br J Cancer 2004;90:822–832.

Hsiao YW, Liao KW, Hung SW, et al. Tumor-infiltrating lymphocyte secretion of IL-6 antagonizes tumor-derived TGF-beta and restores the lymphokine-activated killing activity. J Immunol 2004;172(3):1508–1514.

Kim ES, Kim MS, Moon A. Transforming growth factor (TGF)-beta in conjunction with H-ras activation promotes malignant progression of MCF10A breast epithelial cells. Cytokine 2005;29:84–91.

Cui C, Wang RT, Tong H, et al. Influence of artesunate and oxymatrine on the immunosuppressive effect of mouse colon-rectal carcinoma cell line Colon 26. Current Immun (Chin) 2006;26(2):152–156.

Liu XY, Wang RT, Wang ZH, et al. Artesunate reverses immunosuppresion of L929 tumor cells. Chin J Immun (Chin) 2007;23(11):985–988.

Liu W, Chen H, Xiang JY. Effects of artesunate on the proliferation of human laryngocarcinoma Hep-2 cell line and MEK/ERK, NF-κ B signaling pathway. Herald Med (Chin) 2007;26(11):1267–1269.

Zhang JX, Wang SX, Zhang FG, et al. Primary study of effect of hypoxic killing and radiation sensitivity of artemisinin on human cervical cancer cell. Chin J Cancer (Chin) 2001;20(12):1363–1366.

FULL TEXT LINK

More>

浏览量

373

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Effectiveness of acupuncture for palliative care in cancer patients: A systematic review

Inhibitory effect of cryptotanshinone on angiogenesis and Wnt/β-catenin signaling pathway in human umbilical vein endothelial cells

Electroacupuncture at Zusanli (ST36) accelerates intracerebral hemorrhage-induced angiogenesis in rats

Bone marrow angiogenesis in patients presenting with differential Chinese medicine syndrome: Correlation with the clinico-pathological features of aplastic anemia