Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type

Zai-jian Wang; Hui-xia Li; Jing-hua Wang; Fan Zhang

doi:10.1007/s11655-008-9001-2

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Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type

OriginalPaper | Updated：2021-08-27

- Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type
- Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type
- 中国结合医学杂志（英文版） 2008年14卷第3期页码：185-189
- Affiliations：
  
  1. Department of Digestive Medicine, the Third Hospital Affiliated to Beijing University of Chinese Medicine,Beijing,China
  2. Department of Digestive Medicine, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-008-9001-2
  中图分类号：
- 纸质出版日期：2008，
  
  网络出版日期：2008-10-14，
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Wang, Zj., Li, Hx., Wang, Jh. et al. Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type., Chin. J. Integr. Med. 14, 185–189 (2008). https://doi.org/10.1007/s11655-008-9001-2

Zai-jian Wang, Hui-xia Li, Jing-hua Wang, et al. Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type[J]. Chinese Journal of Integrative Medicine, 2008,14(3):185-189.
Wang, Zj., Li, Hx., Wang, Jh. et al. Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type., Chin. J. Integr. Med. 14, 185–189 (2008). https://doi.org/10.1007/s11655-008-9001-2 DOI：

Zai-jian Wang, Hui-xia Li, Jing-hua Wang, et al. Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type[J]. Chinese Journal of Integrative Medicine, 2008,14(3):185-189. DOI： 10.1007/s11655-008-9001-2.

摘要

To evaluate the effect of Shugan Jianpi Granule (舒肝健脾颗粒

SJG) on the number of gut mucosal serotonin-positive cells (5-HT+C) in patients with irritable bowel syndrome (IBS) of stagnated Gan-qi attacking Pi (SGAP) syndrome type. Twenty-four patients were randomized equally into three groups. All were treated with the basic conventional treatment by cognition-behavior therapy with assistance of lactein 3 tablets thrice a day. Additionally

24 g of SJG was given three times a day to group A

and the same dosage of SJG and Smecta 15 g thrice a day was given to group B

while no additional treatment was given to the control group. The number of 5-HT+C was measured respectively before and two weeks after treatment by immunohistochemical method. The number of 5-HT+C decreased after treatment in all the three groups (P<0.05)

but the decrement was more significant in the two test groups than in the control group (P<0.05 and P<0.01

respectively)

while comparison of 5-HT+C between the two test groups showed insignificant difference (P>0.05). SJG can reduce the number of 5-HT+C in IBS patients of SGAP syndrome type

and its effect is enhanced when used in combination with Smecta.

Abstract

To evaluate the effect of Shugan Jianpi Granule (舒肝健脾颗粒

24 g of SJG was given three times a day to group A

and the same dosage of SJG and Smecta 15 g thrice a day was given to group B

but the decrement was more significant in the two test groups than in the control group (P<0.05 and P<0.01

respectively)

while comparison of 5-HT+C between the two test groups showed insignificant difference (P>0.05). SJG can reduce the number of 5-HT+C in IBS patients of SGAP syndrome type

and its effect is enhanced when used in combination with Smecta.

关键词

Shugan Jianpi GranuleIrritable Bowel Syndromeserotonin

Keywords

Shugan Jianpi GranuleIrritable Bowel Syndromeserotonin

references

Costedio MM, Hyman N, Mawe GM. Serotonin and its role in colonic function and in gastrointestinal disorders. Dis Colon Rectum 2007; 50:376–388.

Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 2006;130:1377–1390.

Chen ZS, Zhang WD, Wei BH, et al. Schedule for diagnosis and treatment for irritable bowel syndrome with integrative Chinese and Western medicine (Draft). Chin J Integr Tradit West Med (Chin) 2005;25(3):282–284.

Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007;132:397–414.

Wang ZJ, Ouyang Q, Zou YG, et al. Comparison of mucosal serotonin content in patients with ulcerative colitis and irritable bowel syndrome. Chin J Intl Med (Chin) 2005;44(11):851–852.

Wang ZJ, Ouyang Q, Wei B, et al. Alteration of intestinal mast cells in cases with overlap syndrome inside ulcerative colitis and irritable bowel syndrome. J Clin Intl Med (Chin) 2005;22(10):674–677.

Han MH, Chen TQ. Exploration on evolvement rule and syndrome differentiation of diarrea-predominant irritable bowel syndrome. Guangming J Tradit Chin Med (Chin) 2007;22(3):35–36.

Qin ZS, Wang Y, Zhao Y, et al. Effect of Shugan Jianpi Granule on VIP and IL-10 in rats with ulcerative colitis. Jilin J Tradit Chin Med (Chin) 2007;27(3):48–50.

Tao Y, Chen DM, Dong MX, et al. The clinical study on Shugan Decoction in treating diarrhea-predominant irritable bowel syndrome. Chin Arch Tradit Chin Med (Chin) 2007;25(10):2190–2193.

Atkinson W, Lockhart S, Whorwell PJ, et al. Altered 5-hydroxytryptamine signaling in patients with constipation and diarrhea-predominant irritable bowel syndrome. Gastroenterology 2006;130:34–43.

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