Latest Issue
Vol. 9 ， Issue 2 ， 2003
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- Keywords：Anorexia Nervosa;PCOS Patient;Arcuate Nucleus;Herbal Formula;Western Medi
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Published：2021-08-27 - Abstract：Objective: To observe the clinical effect of Neiyifang (NYF) in treating endometriosis and to explore its therapeutic mechanism through observing its influence on plasma β-endorphin (β-EP) in different menstrual stages and levels of prostaglandins (PGs) in menstruation.Methods:NYF was administered to 104 patients with endometriosis one dose daily with 3 successive menstrual cycles as one therapeutic course. Peripheral blood β-EP level in follicular, luteal and menstrual stages, as well as PGF2α, PGE2, thromboxane B2 and 6-keto-PGFl α levels in menstrual stage were detected by RIA, and controlled with those in 15 healthy persons.Results: (1) The total effective rate of NYF was 81.3% and it showed significant effect in improving patients’ clinical symptoms and physical signs; (2) In menstrual stage, the levels of β-EP, 6-keto-PGFα/ TXB2 were lower(P <0.05) and levels of PGF2α, PGE2, TXB2 and 6-keto-PGF1α were higher (P< 0. 05) in patients than those in control, and the higher the level of PGE2, the severer the menalgia, (3) NYF could increase levels of β-EP, 6-keto-PGF1α, and reduce levels of PGF2α, PGE2α in menstrual stage of patients (all P<0.05).Conclusion: (1) NYF has good clinical effect in treating endometriosis; (2) Patients’ symptom of menalgia is closely related with the excessive high levels of PGF2α and PGE2, PGI2/TXA2 ratio disturbance, and excessive low level of β-EP; (3) NYF could significantly decrease the PGE2, PGF1α levels, increase the 6-keto-PGF1α/TXB2 ratio and the level of β-EP, so as to alleviate the menalgia in patients with endometriosis.Keywords：endometriosis;prostaglandin;β-endorphin;Neiyifang
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Published：2021-08-27 - Keywords：endometriosis;Diatrizoate;Dilatation Rate;Activate Blood Circulation;garlicin
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Published：2021-08-27 - Abstract：Objective: To compare the effects of treatment of tubal pregnancy (TP)and its following second pregnancy by intratubal methotrexate injection (IMI) alone and combination of IMI with Chinese herbal medicine.Methods: Thirty-five patients suffering from unruptured TP were divided into two groups at random, to the 19 patients in the treated group, the treatment of combined IMI with Ectopic Pregnancy decoction No. 2 (EP2, a traditional Chinese medical decoction) was applied, and to the other 16 patients in the control group, IMI alone was applied for control. Serum concentrations of human chorionic gonadotropin β (β-HCG), size of the gestational sac, existent time of fetal cardiac beat and peritoneal fluid were measured before and after treatment. And hysterosalpingography were performed 6 months after ending the treatment to verify the presence of tubal obstruction and the condition of relapse.Results: The treatment of all the 35 women was successful. The recovery duration of serum β-HCG, disappearance duration of TP sac and existent time of peritoneal fluid in the treated group were 20.0±7.8 days, 1.2±0.7 months and 10.7±2.9 days respectively, which were significantly different from those in the control group (24. 4 ±8.1 days, 3.6±1.7 months and 19.1±3. 2 days respectively(P<0.05, P<0.01 and P<0.05 respectively), but the existent time of fetal cardiac beat in the two groups (8.8±1.9 days vs 9.0±l. 3 days) was not significantly different (P>0.05). The post-treatment oviduct obstructive rate in the two groups was 10.5% and 43.8% respectively, that in the treatment group was less significant (P<0.05). The relapse rate of EP in the treatment group was insignificantly different from that in the control group (5.3% vs 18.8%, P>0.05).Conclusion: The two therapies (IMI alone and IMI combined with EP2) could obtain equal efficacy in curing TP. Compared with IMI alone, the combined therapy appears to have the effects of accelerating the resorption of gestational sac and peritoneal fluid, improving the patency of fallopian tube and ameliorating the circumstance of pregnancy, which is favorable to improvement of the re-pregnancy rate and reduction of the re-occurrence of ectopic pregnancy as well as to the enhancement of the effect of IMI in killing trophocytes. But there is not enough proof to show the potency of EP2 in killing embryo.Keywords：methotrexate;Tubal pregnancy;Traditional Chinese Medicine
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Published：2021-08-27 - Keywords：ectopic pregnancy;Placebo Control Group;Tubal pregnancy;Acute Viral Myocarditis;Integrate Chinese Medicine
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Published：2021-08-27 - Abstract：Objective: To evaluate the effect of combined therapy of Chinese herbal medicine and compound cyproterone acetate (CPA) in treating non-obesity polycystic ovarian syndrome (PCOS) and to explore its mechanism in improving withdrawal ovulation.Methods: Eighty-six patients of non-obesity PCOS, typed as Shen-deficiency with blood stasis Syndrome or Shen-deficiency with Phlegm-Dampness Syndrome by Syndrome Differentiation in traditional Chines medicine, were randomly divided into three groups: (1) The TCM group (n=26) was treated with Chinese drugs for 6 menstrual cycles; (2) The western medicine (WM) group (n=30) was treated with 1 tablet of CPA for 21 days, with the treatment beginning from the 5th day of menstruation. The treatment was given for 3 menstrual cycles by repetitious medication, which stopped and restarted on the 5th day of withdrawal bleeding. Then the ovulation promoting therapy was applied by using clomifene citrate and human chorionic gonadotropin (CC/hCG) for 3 menstrual cycles; (3) The TCM-WM group (n=30) was treated with the medications used for the above two groups. The menstrual cycle, the volume and duration of the menstruation, as well as the improvement of acne and pilosis [Ferrinian-Gallway (F-G) scoring] were observed after 3 cycles ended. Moreover, condition of ovulation was monitored by B-ultrasonography at the 4th-6th cycle and status of pregnancy was observed.Results: Compared with before treatment, the blood level of luteinizing hormone (LH) and testosterone (T) in all 3 groups after treatment significantly decreased (P<0.05), with its ratio to follicle-stimulating hormone (LH/FSH) recovered to normal, but without markedly change in levels of FSH, estradiol (E2) and prolactin (PRL). The menstrual cycle in most patients got regular and acne significantly alleviated (P<0.05), and the improvement of infrequent menstruation and acne was better in the WM group and the TCM-WM group than that in the TCM group, but pilosis showed no significant improvement in all three groups. The periodical ovulation rate in the TCM-WM group (73.1%) and the WM group (68.3%) was significantly higher than that in the TCM group (40%). The pregnancy rate in the TCM-WM group (53.8%) was significantly higher than that in the other two groups (26.1% and 25% respectively, all P<0.05).Conclusion: Using combined therapy of TCM and composite CPA followed by ovulation promoting agents of TCM and WM to treat patients of non-obesity PCOS could relieve the clinical symptoms, improve the abnormal blood level of sex hormones and significantly elevate the pregnancy rate.Keywords：Infertility;polycystic ovarian syndrome;integrated traditional and western medicine therapy
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Published：2021-08-27 - Abstract：Objective: To observe the effect of Astragalus Injection (AI) on left ventricular remodeling in aged patients with acute myocardial infarction (AMI).Methods: Patients with AMI were randomly divided into the AI group (46 cases) treated with AI and the control group (46 cases) treated conventionally. Left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI), anterior endocardial segmental length (ASL) and posterior endocardial segmental length (PSL) were all assessed by echocardiogram after 1 week and 4 weeks treatment. The cardiac systolic and diastolic functions were detected by nuclide gating cardiac blood pool imaging at the 4th week.Results: After four weeks’ treatment, no obvious change of LVEDVI, LVESVI and ASL in the AI group was found, but these indexes increased significantly in the control group, with significant difference shown between the two groups (P<0.05). As compared with the control group, the left ventricular ejection fraction (LVEF), left ventricular peak ejecting rate (LVPER) and left ventricular peak filling rate (LVPFR) were heightened, the time for peak filling rate (LVTPFR) in the left ventricle was shortened in the AI group.Conclusion: AI is one of the effective drugs in reversing left ventricular remodeling in aged patients with AMI.Keywords：myocardial infarction;the aged;left ventricular remodeling;Astragalus Injection
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Published：2021-08-27 - Abstract：Objective: To compare the effect of Keyin Decoction with retinoic acid in treating psoriasis.Methods: One hundred and six patients were randomly divided by paired grouping into the KYD group and the all-trans retinoic acid (RA) group, 53 in each group with 19 cases belonging to Wind-Heat Syndrome type and 34 to Wind-Dryness type. The Wind-Heat Syndrome type in the KYD group was treated with KYD I (with the action of clearing Heat, removing Dampness, cooling blood and dispelling Wind), and the Wind-Dryness type with KYDII (with the action of nourishing blood, moistening skin and dredging Qi-blood circulation). The RA group was treated with RA. Sequential analysis was adopted to observe the effect. At the same time, the adverse reaction was observed.Results: When the test got to the 44th pair of patients, the scription of result reached the UA line of sequential chart, suggesting that the efficacy of KYD was superior to that of RA. Skin lesion subsidence rate in the KYD group and the RA group was 39.6% and 20.8% respectively with significant difference (P<0.05). And for the patients of progressive phase in the two groups, skin lesion subsidence rate was 57.8% and 21.1% respectively (P< 0.05). No obvious adverse reaction was found in the KYD group.Conclusion: Keyin Decoction had good effect in treating psoriasis.Keywords：Keyin Decoction;psoriasis;sequential analysis
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Published：2021-08-27 - Keywords：psoriasis;Retinoid;Dermatol;Nail Fold;Pathologic Histology
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Published：2021-08-27 - Abstract：Objective: To seek a new biochemical index for diagnosis of coronary heart disease (CHD) of shen-Yang deficiency syndrom (CHD-SYD).Methods: Sixty-one patients with CHD were divided into 3 groups according to their TCM Syndrome type, 10 patients in the group without Xin-Qi deficiency (Group A), 25 in the group with Xin-Qi deficiency but without Shen-Yang deficiency (Group B) and 26 in the group both with Xin-Qi deficiency and Shen-Yang deficiency (Group C). Levels of 17-hydroxy-corticosteroid in urine (urinary 17-OHCS) per 24 hrs, and serum level of high density lipoprotein cholesterol (HDL-C) and high density lipoprotein phospholipid (HDL-PL) in them were determined in synchrostep and compared with those in the control group of 23 healthy aged persons, urinary 17-OHCS per 24 hrs was taken as the diagnostic standard to screen a new index for diagnosis of Shen-Yang deficiency Syndrome, and preliminary appraisal to the index was made.Results: Serum HDL-PL in the CHD-SYD patients(Group C) was 616±157 mg/L, which was obviously lower than that in the patients of Group A and B. With low HDL-PL (<650 mg/L) used as the index to diagnose CHD-SYD, the sensitivity was 73%, the specificity 86% and the accuracy 80%.Conclusion: HDL-PL <650 mg/L could be adopted as an index for CHD-SYD diagnosis, which is simple and practical.Keywords：coronary heart disease;Shen-Yang deficiency Syndrome;urinary 17-hydroxy-corticosteroid;serum high density lipoprotein phospholipids;serum high density lipoprotein cholesterol
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Published：2021-08-27 - Abstract：Objective: To explore the relationship of Traditional Chinese Medicine (TCM) Syndrome type and coronary arteriography (CAG) with respect to the number and degree of stenosed branches of coronary artery (CA) and ACC/AHA stage of acute coronary syndrome (ACS), to provide an objective evidence for TCM Syndrome typing on ACS.Methods: Ninety patients of ACS with their TCM Syndrome typing and CAG successfully conducted were enrolled in this study. They were classified into 3 Syndrome types, the blood stasis type (type I), the phlegm stagnant with blood stasis type (type II), and the endogenous collateral Wind type (type III) The scores of the number and severity of the stenosis branch of CA and ACC/AHA lesion stage in different Syndrome types were calculated respectively and analysed statistically byRidit analysis.Results: The number of stenosed branches increased gradually with the Syndrome type changing from I → II → III, compared the type III with the other two types(PKeywords：coronary heart disease;acute coronary syndrome;TCM Syndrome type;coronary arteriogrphy
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Published：2021-08-27 - Abstract：Objective: To explore the mechanism of Qingre Buyi Decoction (QBD) in prevention and treatment of radiation enteritis in rats.Methods: Forty-eight Wistar rats were randomly divided into four groups, the TCM group, the WM group, the model group and the control group, 12 in each group. Rats in the former three groups were given orally with QBD, norfloxacin and normal saline once a day for 7 successive days, after being irradiated with X-ray at single dose of 10 Gy for modeling of radiation enteritis, while rats in the control group were untreated. Animals were sacrificed at the end of the medication. NO concentration, mean height and number of villi per centimeter in their small intestinal mucosa were measured.Results: The intestinal NO concentration was significantly lower in the TCM and WM groups than that in the model group(P<0.05), while the number of villi was significantly more and the height higher in the former two groups than those in the model group (PKeywords：Qingre Buyi Decoction;Radiation Enteritis;Nitric Oxide;histomorphology;rats
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Published：2021-08-27 - Keywords：Nitric Oxide;Renal Fibrosis;Cholesterol Acyltransferase;Radiation Enteritis;Retention Enema
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Published：2021-08-27 - Abstract：Objective: To investigate the effects of electroacupuncture and ischemic preconditioning (IPC) on circulatory function in pigs with myocardial ischemia/reperfusion injury.Method: Eighteen pigs with myocardial ischemia/reperfusion injury were randomly allocated into three groups, 6 in each. Group I was the control group, group II was the group that received IPC, and group III was that received both electroacupuncture and IPC Blood malondialdehyde (MDA), Superoxide dismutase (SOD), creatine phosphokinase (CPK) and its isoenzyme (CK-MB), coronary artery flow and myocardial heat-shock protein (HSP) mRNA expression were detected for evaluation.Results: After treatment, the MDA content was decreased and SOD activities increased significantly in the acupuncture and IPC group compared with the control group (P<0.05 respectively). The levels of CPK, CK-MB at 20, 60 min after reperfusion were significantly higher than those before treatment, but the levels in group III and group II were remarkably lower than those in group I. HSP70 mRNA expression was found to be increased in group II and group III at 60 min after ischemia/reperfusion compared with those in group I.Conclusion: Electroacupuncture can enhance the myocardial protection of IPC against ischemia/reperfusion injury. The. protective mechanism may be related to the improvement of antioxidation and the increased expression of HSP70 gene.Keywords：electroacupuncture;ischemia/reperfusion injury;ischemic preconditioning;malondialdehyde;superoxide dismutase
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Published：2021-08-27 - Keywords：Heat Shock Transcription Factor;Protective Material;Heat Shock Gene;Primary Osteoporosis;Sham Operation Group
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Published：2021-08-27 - Abstract：Objective: To study the therapeutic mechanism of Santeng Dingtong recipe (STDT) on monosodium urate crystal (MSU) induced rabbit arthritis.Methods: Forty-two rabbits were randomly divided into six groups, 7 in each group. Group 1 received 0.9% saline 2.5 ml/kg per day by gastrogavage (ig) for 10 days; Group 2, 3 and 4 received STDT 0.125 g/kg, 1.0 g/kg and 8.0 g/kg per day respectively by ig for 10 days; Group 5 received colchicine 4.5 mg/kg per day by ig for 4 days; and Group 6 was untreated. MSU crystals 10 mg /500 μl containing polymyxin B 10 u/ml was injected into the knee joints of Group 1–5 to make rabbit arthritis models. Leukocytes in synovial lavage fluids was then counted and differentiated; pathological injury of synovial membranes was observed under HE staining; interleukin-1 beta (IL-lβ), tumor necrosis factor alpha (TNFα) and leukotriene B4 (LTB4) content in synovial lavage fluids were determined by ELISA.Results: MSU caused a rapid leukocyte infiltration and increased production of IL-lβ, TNFα and LTB4 2 hrs after intra-articular injection. STDT inhibited neutrophil infiltration in synovial fluids dose-dependently, protected the synovial membrane against pathological injury and reduced the production of IL-lβ, TNFα and LTB4; while colchicine did not decrease the level of TNFα, but significantly inhibited neutrophil infiltration in synovial fluid and reduced the production of IL-11β and LTB4.Conclusion: STDT exerts an anti-inflammatory effect in rabbit model of acute MSU arthritis, its mechanism being probably due to the decrease of IL-1β, TNFα and LTB4 synthesis.Keywords：Santeng Dingtong recipe;colchicine;monosodium urate crystal;rabbit;Arthritis;interleukin-1 beta;tumor necrosis factor alpha;leukotriene B4;enzyme linked immunosorbent assay
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Published：2021-08-27 - Abstract：Objective: To investigate the effect of Kaiyu Qingwei granule (KYQWG) on the insulin binding capacity of liver and skeletal muscular cell membrane and serum insulin-like growth factor-1 (IGF-1) in streptozotocin-induced diabetic rats.Methods: Rats in four experimental groups were investigated: the control group, the model group, the KYQWG group and the Metformin group. The insulin binding rate (IBR) of liver and skeletal muscular cell membrane was detected by receptor-ligand radiometric method and changes of serum levels of glucose, insulin and IGF-1 were observed before and after 4 weeks of medication.Results: The KYQWG group had a lower blood glucose level and IBR of liver and muscular cell membrane, as compared with those in the model group (P<0.01 or P<0.05), and a higher level of IGF-1 than that in the model group(P<0.01), but had no obvious changes in the serum level of insulin.Conclusion: KYQWG may increase the serum level of IGF-1 in diabetic rats, thus to decrease the insulin resistance at ante-receptor sites and improve the sugar metabolic disturbance in rats with diabetes mellitus.Keywords：Kaiyu Qingwei granule;diabetes mellitus;Insulin Receptor;insulin-like growth factor-1;rat
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Published：2021-08-27 - Keywords：Insulin Concentration;Proinsulin;Decrease Blood Glucose;Glucose Transport System;Insulin Receptor Binding
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Published：2021-08-27 - Keywords：Chinese Medicine;endometriosis;Pelvic Pain;Pelvic Inflammatory Disease;Visual Analog Pain Scale
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Published：2021-08-27 -
Quality of Life and Chinese medicine —The development of health status measures for Chinese medicine
Keywords：Chinese Medicine;endometriosis;Pelvic Inflammatory Disease;Transcutaneous Electrical Nerve Stimulation;Health Status Measure- 85
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Published：2021-08-27 - Keywords：Candida Albicans;Chinese Herbal Medicine;Clotrimazole;Vaginal Discharge;Vaginal Douche
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Published：2021-08-27 - Keywords：Thalassemia;Vaginitis;Turtle Shell;Myleran;Candidal Vaginitis
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Published：2021-08-27 -
Progresses in integrated traditional Chinese and western medical research on reproductive immunology
Keywords：Estrogen Replacement Therapy;Premature Ovarian Failure;recurrent spontaneous abortion;Promote Blood Circulation;climacteric syndrome- 640
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Published：2021-08-27 - Keywords：Adverse Reaction;Hepatic Encephalopathy;Oleanolic Acid;Aristolochic Acid;Aconitine
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Published：2021-08-27 - Keywords：Chinese Medicine;Traditional Chinese Medicine;Western Medicine;Chinese Character;Pathogenic Factor
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Published：2021-08-27 - Keywords：Skin Disease;Connective Tissue Disease;Dermatomyositis;Lichen Planus;Integrative Medicine
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Published：2021-08-27 - Keywords：Traditional Chinese Medicine;endometriosis;Neopterin;Blood Stasis;Total Effective Rate
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Published：2021-08-27 - Keywords：endometriosis;Neopterin;Positive Control Group;Serum Content;VEGF mRNA
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Published：2021-08-27 - Keywords：Traditional Chinese Medicine;Ginsenosides;Chinese Herbal Medicine;Lewis Lung Carcinoma;Lewis Lung
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Published：2021-08-27
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