Latest Issue
Vol. 10 ， Issue 3 ， 2004
- Keywords：Chinese Medicine;Randomize Clinical Trial;Bone Marrow Inhibition;Syndrome Differentiation;Tional Chinese Medicine
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Published：2021-08-27 - Abstract：Objective: To observe the effect of Xiaoyu Zhixue tablet (XYZXT) on the expression of platelet membrane glycoproteins in patients with hemorrhagic thrombopathy, and to explore its possible mechanism. Methods; The total of 148 patients with hemorrhagic thrombopathy were randomly divided into two groups, the traditional Chinese medicicne (TCM) group (n = 98) treated with XYZXT and the Western medicine (WM) group (n = 50) treated with adrenosin, vitamins C, K and P, both for 6 months. The therapeutic effect and the recovery rate of platelet aggregation in the two groups were observed. And platelet membrane glycoprotein (GP) Ib/IX, GPII b/IIIa complexes, GPIb, GPIIb, GPIIIa and P-selectin were analyzed by flow cytometry in both groups before and after treatment and also in 34 normal healthy subjects.Results: The total effective rate of hemostasis was 89.8% in TCM group and 54.0% in the WM group (X 2=45.83,P<0.01), and the recovery rate of platelet aggregation was 72.4% and 4.0% respectively (X 2 = 62.06,P<0.01). The fluorescence intensity of GP I b/IX, GP II b/III a complexes, GPIb, GP IIIa and P-selectin were lower in both groups before treatment than those in the healthy subjects. Expression of above-mentioned marks was elevated in TCM group after 6 months’ therapy, which was insignificantly different as compared with the healthy subjects (P>0.05) and higher than those in the WM group (P<0.05).Conclusion: One of the mechanisms in treating hemorrhagic thrombopathy with XYZXT is that it could regulate the expression of GP I b/IX, GPII b/IIIa complexes, GP I b, GPIIIa and P-selectin at the level of receptor protein.Keywords：hemorrhagic thrombopathy;Xiaoyu Zhixue Tablet;platelet membrane glycoproteins
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Published：2021-08-27 - Keywords：Energy Charge;Platelet Membrane;Activate Blood Flow;Membrane Glyco;Preserve Liquid
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Published：2021-08-27 - Abstract：Objective: To explore the efficacy of Tongkuaixiao Babu plaster (TKXBBP) in treating cancer pain.Methods: In the clinical observation, sixty-five patients with moderate or severe cancer pain were randomly divided into two groups: 32 in the treated group (TKXBBP group) and 33 in the control group (Bucinnazine group). The therapeutic effects in relieving pain, improving quality of life (QOL), and the rate of satisfaction the patients felt of the two groups were compared respectively. Results: TKXBBP was effective in treating cancer pain. There wasn’t any statistically significant difference in total effective rate (P>0.05), but the statistical difference was significant in obvious remission rate (P<0.05) between the treated and control group, and the effect on serious pain shown in the treated group was better than that of the control group (P<0. 05). The difference in the initiation time of relieving cancer pain was insignificant (P>0.05), while in the remission period, the treated group showed its treatment was obviously superior to that of the control group (P<0.05). TKXBBP showed better effect in the improvement of QOL (P<0.05) and satisfaction rate, with significant difference between the treated and the control groups (P<0.01).Conclusion: TKXBBPs effect in treating cancer pain was obvious, its application was safe and convenient. It was shown that the external treatment with this kind of Chinese medicine had great advantage in treating cancer pain.Keywords：cancer pain;quality of life;external treatment with Chinese medicine
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Published：2021-08-27 - Abstract：Objective: To observe and compare the effect of traditional Chinese medicine (TCM) combined with chemotherapy (CT) on immune function and quality of life (QOL)of patients with non-small cell lung cancer (NSCLC) in stage III-IV.Methods: One hundred cases with stage III-IV NSCLC were randomly divided into two groups. The treated group (n = 50) received CT combined with TCM, and the control group received CT alone. The percentage of T lymphocyte subset in peripheral blood and the change of natural killer (NK) cell count were observed after treatment. The QOL and tolerance of CT were also compared between the two groups after treatment. Results: In the treated group, CD3 cell count, CD4 cell count, CD4/ CD8 ratio and NK cell activity were higher than those in control group, while CD8 cell count in the treated group was lower than that in the control group (P<0.05), and QOL and tolerance of CT in the treated group were also better (P<0.05).Conclusion: TCM combined with CT could raise the patients’ ability in tolerating CT in stage III-IV NSCLC.Keywords：non-small cell lung cancer in stage III-IV;traditional Chinese medicine combined with chemotherapy;immune function;quality of life
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Published：2021-08-27 - Keywords：Acute Myelocytic Leukemia;esophageal cancer;retinoic acid;Lung Cancer Patient;Combine Regimen
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Published：2021-08-27 - Abstract：Objective: Cordyceps sinensis (CS) is a popular natural Chinese herbal medicine for invigoration, health preservation and reducing fatigue. Its natural substance has been prepared as a fermentation product of a specific strain of Cordyceps sinensis (Cs-4). Our objective was to assess the effect of Cs-4 on the exercise capacity of the healthy elderly people in a randomized, double-blind, placebo-controlled trial.Methods: Thirty-seven healthy, elderly Chinese subjects were randomly assigned to receive either Cs-4 (3 g/ day) or identical placebo capsules. Their exercise performance was tested before and after 6 weeks of treatment with a symptom-limited, incremental work rate protocol on a cycle ergometer. Maximum oxygen uptake (VO2max) was measured using a metabolic chart. Anaerobic thresholds (VO2θ) were identified by two observers using plots of both VCO2 vs VO2 and VE/VO2 vs time.Results: After taking Cs-4 for 6 weeks, VO2max (1.88 ±0.13 to 2.00 ±0.14 L/min;P = 0.050) and VO2θ (1.15 ±0.07 to 1.30 ±0.09 L/min;P = 0.012) were significantly increased, whereas after placebo application they were unchanged.Conclusion: These findings support the belief held in China that Cs-4 could improve oxygen uptake or aerobic capacity and ventilation function and resistance to fatigue of elderly people in exercise.Keywords：Cordyceps sinensis;Cs-4;aerobic capacity;ventilation;elderly;exercise
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Published：2021-08-27 - Abstract：Objective: To explore the effect of Tripterygium polyglycoside (TP) associated with nicotinamide on the islet cell function, immune parameters and lipoperoxide (LPO) in adult patients with late-onset autoimmune diabetes mellitus (LADA).Methods: Thirty-six cases of LADA were randomly divided into three groups: TP group (n = 12), treated with TP plus orally taken metformin; combined treatment group (n = 12), treated with TP combined with nicotinamide and metformin, and control group (n = 12) treated with metformin alone. They were followed-up for 18 months.Results: (1) Compared with the control group after 9 months of treatment, postprandial plasma glucose and LPO in combined treatment group were decreased (P <0.05), and the postprandial C-peptide was higher (P<0.05). At the 18th month, the value of postprandial C-peptide in the TP and combined treatment group was higher than that in the control group. The slL-2R level of both TP and combined treatment groups were lowered (P<0.01); (2) Islet cell antibody (ICA) positive of 5 cases in the TP group and 6 cases in the combined treatment group got converted to the negative respectively, while only one in the control group at the time (P<0.05); (3) The level of LPO in the combined treatment group was significantly lower than that in the TP group at the 18th month of treatment (P<0.05).Conclusion: TP combined with nicotinamide played a role in immunity regulation, decreasing the titer of islet cell antibody and slL-2R, which also reduced the production of LPO and had a tendency to improve islet cell function in early LADA patients.Keywords：late-onset autoimmune diabetes mellitus in adults;Tripterygium;nicotinamide
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Published：2021-08-27 - Abstract：Objective: To assess the efficacy and safety of compound Salvia pellet (CSP) in treating hypertensive cerebral hemorrhage (HCH).Methods: Control group (n = 116) was given HCH conventional therapy, and the treated group (n = 118) given the same conventional therapy plus CSP 10 pills through sublingual sucking/6 hrs, the efficacy was compared.Results: (1) The 3rd day after admission CT monitoring showed both the volume of hematoma and hematoma plus edema in the treated group were smaller than those in the control group, the difference was significant (P<0.05); comparison between 14th day and 28th day after admission showed that the difference was significant (P<0.01). (2) The 14th day, 28th day and 3 months after admission, regarding the Chinese stroke scale (CSS), activity of daily living (ADD and modified Barthol index (BI), the treated group was better than that of control group, the difference was significant (P<0.01). (3) The incidence of brain-heart syndrome reduced as time went by in both groups, but that of the treated group lowered more than that of control group, the difference being significant (P<0.05, orP< 0.01).Conclusion; CSP in treating HCH patients could cease the expansion of cerebral hematoma in the early phase, and accelerate the absorption of cerebral hematoma, improve the cerebral blood flow, alleviate cerebral edema, lower the disability, and elevate the quality of life. Besides, CSP also could prevent and treat brain-heart syndrome. CSP is cheap, convenient in administration, effective and safe.Keywords：compound Salvia pellet;hypertensive cerebral hemorrhage;efficacy
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Published：2021-08-27 - Abstract：Objective: To observe the effect of Xuesaitong (XST) soft capsule in interference treatment on patients of nephrosis syndrome (NS) during corticosteroid (CS) dose reducing stage.Methods: Seventy-one NS patients applying prednisone and initiating dose reducing stage were randomized into trial group and control group. On the basis of conventional prednisone dose reduction of both groups, the trial group was given additionally XST, and the treatment course ended with the reduction to maintenance dose. In the course of observation, those who did not comply with the criteria of observation were excluded. Before and after the dose reduction, TCM syndrome scoring, 24 hrs urinary protein amount, blood β2-microglobulin (β2-MG), urinary β2-MG, blood fibrinogen (Fbg), plasma prothrombin time (PT), blood lipid, etc. were observed.Results: The trial group of XST could obviously lower their urinary protein amount and blood lipid level (P<0.05 orP<0.01), markedly improve the blood coagulation parameters (P<0.01), improve the TCM syndrome and CS induced adverse reaction (P<0.05 orP<0.01), also obviously reduced the recurrence rate of NS (P<0.05).Conclusion: XST could obviously improve the clinical symptoms and renal impairment parameters in NS patients during CS dose reduction stage, improve the CS induced adverse reaction and prevent the recurrence of NS.Keywords：nephrosis syndrome;corticosteroid;Qi deficiency and blood stasis;Xuesaitong soft capsule
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Published：2021-08-27 - Abstract：Objective To explore anti-tumor effect and mechanism of Allicin in treating murine bladder tumor.Methods: To observe Allicin’s effect on MBT-2 tumor cells in vitro, 100 ⧎g/ml Allicin was added to the tumor cell culture, and the morphology of tumor cells was observed by phase contrast microscope 6 hrs later. The direct effects of Allicin on tumor cell growth in vitro in the MTT Assay was also evaluated. To determine anti-tumor effect of Allicin in vivo, C3H/He mice were randomly grouped prior to initiation of experiment. The mice received 1 × 105 MBT-2 cells administered subcutaneously into the right posterior flank on the Day 0 the experiment started. Allicin was injected at the site near tumor transplantation on the Day 1. The mice were examined for tumor development and the tumors were measured in two dimensions with calipers twice a week. On Day 21 the tumors were resected and examined pathologically to see the immune response.Results: The observation of morphology of MBT-2 cells in vitro and MTT assay indicated that Allicin has apparent direct cytotoxicity to bladder cancer cells. In high dosage group, a marked delay was shown in the appearance and growth of tumors after subcutaneously injection when compared with the control group (P< 0.01). Histology studies suggested that there were more macrophages, lymphocytes and fibroblasts at the peri-tumor region than the control group.Conclusion: Allicin has a marked tumor inhibitory effect on bladder tumor. This effect could possibly be related to direct cytotoxicity and activation of immune response. It could as possibly prove to be an effective intravesical treatment agent for superficial bladder cancer.Keywords：allicin;anti-tumor effect;Bladder Tumor
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Published：2021-08-27 - Keywords：Stable Angina Pectoris;Bladder Tumor;Transitional Cell Carcinoma;allicin;Diallyl
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Published：2021-08-27 - Abstract：Objective: To investigate the effect of Red Peony 801 (propyl gallate,PrG) on cyclooxygenase (COX) activity in murine peritoneal macrophages.Methods: A screening model for COX inhibitors in vitro based on murine peritoneal macrophages was used. COX-1 activity was reflected by the level of 6-ketoprostaglandin F1α(6-keto-PGF1α) in supernatants of cultured macrophages which were stimulated with calcium ionophore A23187 for a short-term, while COX-2 activity was reflected by the level of prostaglandin E2 (PGE2) in supernatants of cultured macrophages which were stimulated with lipopolysaccharide (LPS) for a long-term.Results: PrG did not affect A23187-induced, COX-1-derived 6-keto-PGF1α synthesis at the concentrations of 1 × 10-6, 5 × 10-6 mol/L (P>0.05), but enhanced 6-keto-PGF1α synthesis at the concentrations of 1 × 10-6, 5 × 10-7, 1 × 10-7 mol/L (P<0.01) in vitro, and showed a good dose-dependent manner. It inhibited LPS-induced, COX-2-derived PGE2 synthesis at the concentrations of 1 × 10-6, 1 × 10-6 mol/L (P< 0.05).Conclusion: Within the range of 1 × 10-5 to 1 × 10-7 mol/L, PrG activated COX-1 at lower concentrations and inhibited COX-2 at higher concentrations in murine peritoneal macrophages.Keywords：propyl gallate;cyclooxygenase 1;cyclooxygenase 2;inflammation
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Published：2021-08-27 - Abstract：Objective: To explore the effects of Taxol in inhibiting human leukemia k562 cell proliferation and inducing apoptosis in vitro.Methods: Human leukemia K562 cells were treated with Taxol of different concentrations for 12–72 hrs. Cell proliferation was evaluated by MTT assay and morphological changes of apoptosis were examined by microscopy. Cell apoptosis was determined by flow cytometry (FCM) and DNA gel electrophoresis.Results: Growth of K562 cells was inhibited by Taxol with an IC50 value of 0. 84 ⧎g/ml. Typical nuclear condensation and apoptosis bodies were observed as early as 24 hrs after a 0.5 ⧎g/ml Taxol treatment; Apoptotic rate of the Taxol-treated K562 cells increased from 3.7% to 24.0% in 24 hrs. No DNA ladder was observed by DNA gel electrophoresis.Conclusion: Taxol could inhibit K562 cell growth and induce apoptosis in vitro.Keywords：Taxol;Leukemia;K562 cell line;cell apoptosis
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Published：2021-08-27 - Abstract：Objective: To study the antidepressant effects and its mechanism of bioactive compounds (metabolite extract) from entomogenous fungi (BCEF) on experimental animal models of depression.Methods: The antidepressant effect of BCEF was examined on the acquired models of depression (rats and mice in forced swimming test) and unpredictable chronic stress mouse models. The behavior alterations were assayed by detecting the duration of immobility in forced swimming test. UV spectrophotometer analysis technique was used to detect the activity of Superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and catalase (CAT) in mice brain mitochondria; and colorimetric method was used to detect the content of malondealdehyde (MDA), nitrogen oxide (NO) in rat brain cytoplasm and mitochondria.Results: BCEF (25, 50, 100 mg/kg) could obviously shorten the immobility time in forced swimming mice and BCEF (50,100 mg/kg) could obviously shorten the immobility time in forced swimming rats. Both of them showed some extent of dose-effect relationship. BCEF (50, 100 mg/kg) could significantly inhibit the increase of MDA and NO content in brain mitochondria and cytoplasm in chronic unpredictable stress models. BCEF (25,50,100 mg/kg) could obviously enhance the activities of SOD and GSH-PX. BCEF (50 mg/kg) also enhances the activities of CAT.Conclusion: BCEF has antidepressant effects in depressed animal models. The anti-oxidation may be one of the important mechanisms.Keywords：entomogenous fungi;depression;model;lipid peroxidation
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Published：2021-08-27 - Keywords：Transcranial Magnetic Stim;Apigenin;Forced Swimming Test;White Matter Hyperintensities;Chronic Mild Stress
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Published：2021-08-27 - Abstract：Objective: To explore the relationship between Shen deficiency and blood stasis.Methods: Using consecutive intramuscular injection of hydrocortisone to build Shen-yang deficiency model rats, and detect their hemorheological and biochemical parameters.Results: Comparison between the model group and control group showed that the in vitro thrombus significantly lengthened in the model group (P<0.05), the dry weight increased (P<0.01), hematocrit and whole blood viscosity under high sheared change lowered (P<0.05), blood glucose elevated (P<0.01), and RBC infiltration index, aggregation index increased (P close to 0.05).Conclusion: Under the condition of Shen-yang deficiency, although blood does not show such properties of blood stasis as being “viscous, concentrated, coagulated and aggregated”, partial change of hemorheology occurs, and it is liable to form thrombus, which proves that the Shen deficiency status is accompanied with the tendency of blood stasis.Keywords：Hydrocortisone;Shen deficiency;hemorheology
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Published：2021-08-27 - Keywords：nitrogen oxide;Ground Beetle;acute cerebral infarction;Acute Gouty Arthritis;Cerebral Infarction Patient
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Published：2021-08-27 - Keywords：Blood Stasis;Cerebral Ischemic Injury;Activate Blood Circulation;Acute Gouty Arthritis;CGRP Level
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Published：2021-08-27 - Keywords：NSCLC Patient;Maximal Tolerant Dosage;Treatment Cycle;Mune Function;Liver Transaminase Eleva
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Published：2021-08-27 - Keywords：Pancreatic Cancer;Chinese Medicine;Western Medicine;advanced pancreatic cancer;Clinical Benefit Rate
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Published：2021-08-27 - Keywords：Syndrome Differentiation;Vival Rate;Median Survival Period;Rectosigmoid Cancer;Tional Chinese Medicine
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Published：2021-08-27
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