Latest Issue
2006 Year 12 Vol. 2 Issue
- Keywords：Traditional Chinese Medicine;simian immunodeficiency virus;Baicalin;Schisandrin;Chinese Patent Medicine
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Published：2021-08-27 - Keywords：Coronary Heart Disease Event;Coronary Heart Disease Patient;Nonfatal Myocardial Infarction;Coronary Heart Disease Death;Coronary Sudden Death
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Published：2021-08-27 - Abstract：Objective: To observe the effects of conventional therapy combined with Kanlijian (KLJ) on exercise tolerance, quality of life and frequency of heart failure aggravation in patients with chronic heart failure(CHF).Methods: Sixty CHF patients differentiated as sufferring from the syndrome of Xin-Shen Yang deficiency were included in the study and randomly assigned at the ratio of 2: 1 into the KLJ group (n = 39) and the control group(n = 21). All the patients were treated with conventional therapy of Western medicine, but to those in the KLJ group, KLJ was medicated additionally one dose daily with 24 wks as one therapeutic course. The efficacy on TCM syndrome and changes of scores on TCM syndrome were observed after treatment. The indexes, including 6-minute walking distance (6MWD), quality of life (QOL, accessed by LHFQ scoring), NYHA grade, hemodynamic indexes and reducing/withdrawal rate of diuretic and digoxin before and after treatment were recorded and compared. Also the frequency of re-admission due to aggravation of heart failure in one year’s time were observed.Results: (1) The efficacy on TCM syndrome, improvement on scores of TCM syndrome, therapeutic effects on 6MWD, QOL, and NYHA grade in the KLJ group were superior to those in the control group. (2) Hemodynamic indexes after treatment, left ventricular fractional shortening (LVFS) and E peak/A peak (E/A), between the two groups had no significant difference, while left ventricular ejection fraction (LVEF) was increased significantly in the KLJ group, but with no obvious change in the control group. (3) The reducing/withdrawal rate of diuretic and digoxin in the KLJ group was significantly higher than that in the control group. (4) The 1-year frequency of re-admission significantly decreased in the KLJ group.Conclusion: The adjuvant treatment of KLJ on the basis of Western conventional therapy can significantly improve CHF patients’ exercise tolerance, quality of life and cardiac function, reduce the dosage of diuretic and digoxin needed, and decrease the re-admission frequency due to aggravation of heart failure.Keywords：Kanlijian;chronic heart failure;exercise tolerance;quality of life;aggravation of heart failure
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Published：2021-08-27 - Abstract：Objective: To provide evidence for three-level prevention of cholelithiasis by means of observing the effects of some choleretics on bile compositions drained from patients with pigment gallstone.Methods: Twenty-seven patients suffering from primary pigment gallstones and having received treatment of choledochostomies plus T-tube or endoscopic nasal bile drainage (ENBD) were divided equally into three groups, and administered respectively with Lidanling (the LDL group), ursodesoxycholic acid (the UDA group) and combination of LDL and UDA (the LDL + UDA group) through oral intake(7 patients in each group). Besides, 6 post-operational patients got no treatment with any drug were allocated in the control group. Bile of all the patients was collected before treatment and on the 1, 3, 5, 7th day after the treatment started to detect levels of total bile acid (TBA), glycocholic acid (GCA), taurocholic acid (TCA), glycocholic cheno-desoxycholic acid (GCDCA), total bilirubin (TBIL), uncombined bilirubin (UCB), concentration of calcium ion (Ca2+) as well as the bacterio-genetic and endogenous β-glucuronidase activity for comparing.Results: Levels of TBA, GCA, TCA and GCDCA got gradually increased in the UDA group and the LDL + UDA group after treatment (P< 0.05), while those in the LDL group remained unchanged, showing an insignificant difference as compared with those in the control group. In the LDL group and the LDL + UDA group, TBIL gradually increased while UCB gradually decreased in the course of treatment (P< 0.05). Moreover, levels of Ca2+ and endogenous β-glucuronidase activity got significantly lowered (P< 0.05).Conclusion: Combined use of LDL and UDA could elevate levels of TBA, GCA, TCA, GCDCA, enhance the excretion of TBIL in patients with pigment gallstone after bile drainage, lower levels of UCB and Ca2+ and the activity of endogenous β-glucuronidase in the bile, so as to reduce the possibility of stone formation of bile, and therefore, it could be used to prevent the production of pigment gallstone, especially to prevent post-operative recurrence of stones.Keywords：Lidanling;pigment gallstone;bile composition
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Published：2021-08-27 - Abstract：Objective: To study the effect and mechanism of Ganbi decoction (GBD) in treating patients with antituberculotic agent caused liver injury (ATB-LI).Methods: One hundred and twenty-eight patients with ATB-LI were randomly assigned to the treated group (n = 66) and the control group (n = 62) with the envelop method. Meanwhile, 60 healthy persons were selected as the healthy control group. The treated group was treated by GBD one dose every day with the constituents modified depending on patients’ symptoms, and the control group was treated with glucuronolactone tablets and inosine injection. One week was taken as one treatment course. The changes of clinical syndromes, physical signs, T-lymphycyte sub-groups and serum level of nitric oxide (NO) were observed before and after treatment and the recovery time of liver function was recorded. The outcome was compared with that in the healthy control group.Results: In the treated group, 28 patients (42.4%) were cured, 30 (45.5%) improved and 8 (12.1%) ineffectively cured, the total effective rate being 87.9% (58/66). In the control group, 17 patients (27.4%) were cured, 24 (38.7%) improved, and 21 (33.9%) ineffectively cured, the total effective rate being 66. 1 % (41/62). The total effective rate in the treated group was significantly higher than that in the control group (P< 0. 05). Liver function was improved in both groups, recovery time in the treated group was 12.0 ±7.0 days, which was significantly shorter than that in the control group (16.0 ±8.0 days), showing significant difference between the two groups (P< 0.05). The levels of CD3, CD4 and CD8 were significantly higher and level of NO significantly lower in the two groups of patients than those in the healthy control group (P< 0.05), but these parameters were improved more significantly in the treated group after treatment, when compared with those before treatment or with those in the control group, all showing significant difference (P< 0.05).Conclusion: GBD could prevent ATB-LI, and its mechanism could be by way of reducing NO production induced by endotoxin of macrophage and stimulating the proliferation of T-lymphycyte to elevate immunity.Keywords：Ganbi Decoction;anti-tuberculosis agent;liver injury
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Published：2021-08-27 - Abstract：Objective: To observe the effect of Xiaoyao Nose Drops (XYND) in stopping episode of migraine.Methods: Adopted was the randomized double-blinded placebo-controled method, with the 126 patients equally assigned to two groups, the treated group treated with XYND and the control group with placebo, and the therapeutic course was 30 days for all. The clinical total effective rate and effect in alleviating headache were observed. And hemorrheological parameters as well as the blood flow of the anterior cerebral artery (ACA), median cerebral artery (MCA) and posterior cerebral artery (PCA) were measured before and after treatment.Results: The clinical total effective rate and headache alleviating rate in the treated group were 93. 33% and 96. 67% respectively, while those in the control group were 18. 33% and 20.00% respectively, and comparison between the two groups showed significant difference (allP< 0.01). The blood viscosity (high, middle and low shear), plasma viscosity and fibrinogen got lowered significantly in the treated group after treatment, showing significant difference in comparison either with those before treatment or with those in the control group after treatment (P< 0.05 orP< 0.01). The velocity of blood flow in all cerebral arteries lowered significantly, also showing significant difference in comparison either with those before treatment or with those in the control group after treatment (P< 0.05 orP< 0.01).Conclusion: XYND is effective in stopping the headache of patients with migraine, and worth applying in clinical practice.Keywords：Xiaoyao Nose Drops;Migraine;transnasal medication;Clinical Study
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Published：2021-08-27 - Abstract：Objective: To investigate the effect of Chinese recipe, Wuye Decoction (WYD), on immune function in patients with non-small cell lung cancer (NSCLC).Methods: Eighty-two patients of NSCLC with pathologically confirmed diagnosis, who had received operative treatment and completed the post-operational chemotherapy, were randomly assigned into 2 groups. Group A (42 cases) received WYD and Group B (40 cases) received no specific medicine. Positive rate of various peripheral lymphocyte subsets, including CD3, CD4, CD8, CD16, CD19 and CD25, in both groups was observed immediately after chemotherapy (T0) and 3 months later (T1), the same indexes of 20 healthy volunteers allocated in Group C were also determined at T0 for control.Results: The positive rates of CD4, CD4/CD8, CD16, CD19 and CD25 were significantly lower (P< 0.05) while that of CD8 was significantly higher (P< 0. 05) in Group A and B at T0 than those in Group C; at T1, these indexes, except CD25, got significantly restored in Group A with the level approaching normal range (P> 0.05), and showed significant difference from those in Group B (P< 0. 05), since these indexes in that group remained unchanged at the corresponding period. As for CD25, it was insignificantly changed in Group A after WYD treatment, and thus, at T1, it was still lower than that in Group C (P< 0.05) and showed insignificant difference as compared with that in Group B (P>0.05). Comparison of CD3 among the 3 groups showed no significant difference (P> 0.05).Conclusion: WYD could activate the immune function of NSCLC patients, and so it is recommended to be used in the treatment of NSCLC in clinical practice.Keywords：Wuye Decoction;non-small cell lung cancer;chemotherapy;lymphocyte phenotype
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Published：2021-08-27 - Abstract：Objective: To explore the clinical effect of therapy of clearing hallow viscera in treating critical patients with gastro-enteric function disorder (GEFD).Methods: Retrospective analysis was carried out on 96 critical patients. They were 48 patients in the treated group treated with Dachengqi Decoction and 48 patients in the control group treated with Western medicine for promoting gastric dynamic force. The recovery rate, recovery time of gastro-enteric function, incidence rate and fatality rate of multiple organ dysfunction syndrome (MODS), as well as the level of plasma endotoxin (ET) before and after treatment between the two groups were compared.Results: Comparison between the two groups in gastro-enteric function recovery rate (81.3% vs 45.8%), functional disorder sustaining time in patients who got recovered (1.2±0.3 days vs 4.0±1.1 days), incidence rate (29. 17% vs 52.08%) and fatality rate (28.57% vs 56.00%) of MODS all showed significant difference (P< 0.05 orP< 0.01). The plasma level of ET after treatment in the treated group was significantly lower than that in the control group (P< 0. 05).Conclusion: Therapy of clearing hallow viscera has a good effect in treating critical patients with gastro-enteric function disorder, and could reduce the incidence and fatality of MODS.Keywords：therapy of clearing hallow viscera;Dachengqi decoction;gastro-enteric function disorder;Multiple Organ Dysfunction Syndrome
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Published：2021-08-27 - Abstract：Objective: To explore the growth inhibition effects and apoptosis inducing mechanisms of curcumin on human ovarian cancer cell line A2780.Methods: After treatment with 10–50 μmol/L curcumin for 6–24 h, the growth activity of A2780 cancer cells were studied by [4,5-dimethylthiazol-2-yl]-2, 5-dipheny-Itetrazolium bromide (MTT) colorimetry. Cellular apoptosis was inspected by flow cytometery and acridine orange-ethidium bromide fluorescent staining methods. The fragmentation of cellular chromosome DNA was detected by DNA ladder, the ultrastructural change was observed under a transmission electron microscope, and the protein levels of nuclear factor-Kappa B (NF-κB, P65) and cysteinyl aspartate specific protease-3 (Caspase-3) in ovarian cancer cells were measured by immunohistochemistry.Results: After treatment with various concentrations of curcumin, the growth inhibition rates of cancer cells reached 62.05% —89. 24%, with sub-G1 peaks appearing on histogram. Part of the cancer cells showed characteristic morphological changes of apoptosis under fluorescence and electron microscopes, and the rate of apoptosis was 21.5%–33.5%. The protein expression of NF-κB was decreased, while that of Caspase-3 was increased in a time-dependent manner.Conclusion: Curcumin could significantly inhibit the growth of human ovarian cancer cells; inducing apoptosis through up-regulating Caspase-3 and down-regulating gene expression of NF-κB is probably one of its molecular mechanisms.Keywords：Curcumin;ovarian cancer;NF-κB gene;Caspase-3 gene;apoptosis
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Published：2021-08-27 - Abstract：Objective: To observe the effect of Gengnianchun Recipe (GNC) on bone mineral density (BMD), bone biomechanical parameters and serum lipid level in the bilaterally ovariectomized (OVX) rats and to explore the prophylactic and therapeutic action of GNC on ovariectomy induced osteoporosis and hyperlipidemia.Methods: OVX SD rats, 10 –12 months old, were divided into different groups and fed with GNC 2 g/d, GNC 1 g/d and Nilestriol 0. 125 mg/week, respectively for 4 months to observe the change of BMD and bone biomechanical parameters of the lumbar vertebrae, and the serum levels of total cholesterol (TC), triglyceride(TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), and to compare the effect of the two drugs on the morphology of the uterus.Results: There was marked reduction in BMD and biomechanical parameters in lumbar vertebrae (P< 0.01) and increase of serum TC and LDL-C levels (P< 0. 01) in rats after OVX. GNC or Nilestriol significantly improved the decreased BMD and biomechanical parameters of the lumbar vertebrae (P< 0.05 orP< 0.01), and reduced the serum TC and LDL-C levels (P< 0.01). In the Nilestriol group, the wet weight of uterus got increased obviously (P< 0.01), the number of uterine glands increased, uterine columnar epithelium thickened, and the mitotic figures in the epithelial stroma and myointimal cells augmented. But no such effect in wet weight and morphology of uterus was found in the GNC group.Conclusion: GNC could increase the BMD and biomechanical parameters of the lumbar vertebrae, reduce the serum TC and LDL-C levels, yet produce no adverse reaction in stimulating proliferation and hypertrophy of uterus.Keywords：Gengnianchun Recipe;postmenopausal osteoporosis;Bone Mineral Density;bone biomechanics;Total Cholesterol;low-density lipoprotein cholesterol
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Published：2021-08-27 - Abstract：Objective: To explore the effects of Yizhi Capsule (YZC) on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats.Methods: Various doses of YZC were administered to Sprague-Dawley (SD) rats for 8 consecutive days, twice a day. On the 8th day of the experiment, scopolamine hydrobromide was intraperitoneally injected to every rat and Morris water maze test and shuttle dark avoidance test were carried out respectively to explore the changes of learning and memory capacities in the rats. Besides, after the cerebral cortical neurons of newborn SD rats aged within 3 days were culturedin vitro for 7 days, drug serum containing YZC was added to the cultured neurons before or after β amyloid peptide25–35 (Aβ25–35) intoxication to observe the protective effect of YZC on neurotoxicity by MTT assay and to determine the LDH content in the supernatant.Results: Compared with those untreated with YZC, the rats having received YZC treatment got superiority in shorter time of platform seeking in Morris water maze test, as well as elongated latent period and less times of error in shuttle dark avoidance test. On the cultured neurons, YZC drug serum could effectively increase the survival rate of Aβ25–35 intoxicated neurons and reduce the LDH contents in cultured supernatant.Conclusion: YZC has an action of improving learning and memory disorder, and good protective effect on Aβ25–35 induced neurotoxicity in SD rats.Keywords：learning and memory disorder;β-amyloid peptide;neurotoxicity
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Published：2021-08-27 - Abstract：Objective: To explore the therapy to further elevate the efficacy of the treatment of chronic aplastic anemia (CAA).Methods: Forty-five patients with CCA were assigned into two groups, the 26 patients in the treated group were treated by Shengxuening (a Chinese herbal preparation) and cyclosporin A (CsA), and the 19 patients in the control group were treated with androgen alone, with the therapeutic course lasting for over 3 months. Changes of peripheral blood picture, and the colony productivity of burst forming unit-erythroid (BFU-E), colony forming unit-erythroid (CFU-E) and colony forming unit-granulocyte macrophage (CFU-GM) in bone marrow were observed before and after 3 months treatment. The amount of erythrocyte and platelet infusion, frequency of infection, condition of hemorrhage and relevant death were also observed. The follow-up study was conducted for over half a year.Results: The total effective rate in the treated group was 84.6%, which was significantly higher than that in the control group (52.6 %,P< 0.05). Levels of hemoglobin, reticulocyte, neutrophil and platelet increased after treatment in the treated group, as compared with those before treatment, with significant difference (P< 0.05), and the colony productivity of BFU-E, CFU-E and CFU-GM in bone marrow also got significantly increased (P< 0.01), and showed significant difference from those in the control group (P< 0.05).Conclusion: Shengxuening-assisting CsA therapy is an effective measure for treatment of CAA.Keywords：Shengxuening;cyclosporin A;aplastic anemia
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Published：2021-08-27 - Abstract：Objective: To explore the clinical effect of electro-acupuncture (EA) in treating patients with lingual hemangioma (LHG).Methods: EA therapy was applied on 36 patients by directly inserting the platinum needles into LHG through a trocar with plastic insulating cannula to protect the normal tissues and connecting the needles with the electro-chemical therapeutic apparatus of model ZAY-B. Then electricity was given until the tumor body got contracted and rigid. The result was assessed 6 months after EA was started.Results: All patients were treated effectively, namely, the effective rate was 100%, with the therapeutic effect reaching grade I in 29 patients (80. 6%), grade II in 7 (19.4%), and all having the function of tongue recovered to normal.Conclusion: EA shows special superiorities in treating LHG, proved to bring about less injury and quick recovery and being simple in operation. Especially when applied on huge LHG, it could not only remove the tumor, but also preserve the function of the tongue, so it is a brand-new approach that is likely to be accepted by patients.Keywords：lingual hemangioma;electro-acupuncture therapy;Clinical Effect
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Published：2021-08-27
OriginalPaper
Announcement
BookReview
- Abstract：Dry eye is now one of the most common superficial disorders in ophthalmology at home and abroad, and more and more people attach importance to the study. The ideal approach for treatment of dry eye is to normalize the condition by rebuilding the superficial circumstance of the eye, and to make tear film work as well as possible so as to relieve the irritating symptoms in the eye. The authors are making a comprehensive discussion on the methods and curative effects of treating dry eye by traditional Chinese medicine and by integrative Chinese and Western medicine in recent years, so as to introduce the distinctive features of the traditional Chinese medicine and integrative Chinese and Western medicine in this field.Keywords：dry eye;Traditional Chinese Medicine Therapy;integrative Chinese and Western medicine therapy
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Published：2021-08-27
ReviewPaper
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