Latest Issue
Vol. 10 ， Issue 1 ， 2004
- Keywords：High Blood Pressure;Western Medicine;Chinese Herbal Medicine;Chinese Drug;Tional Chinese Medicine
- 768
- |
- 398
- |
- 3
Published：2021-08-27 - Abstract：Objective: To investigate the intervention effect of Jianxin Decoction on the cytokine level in serum of patients with congestive heart failure (CHF).Methods: Sixty-six patients with CHF were randomly divided into the control group (n = 33) and the trial group (n = 33). The control group received conventional treatment, and the trial group was treated with conventional therapy plus JXD for 4 weeks. Before and after treatment, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and nitrogen monoxide (NO) in serum and cardiac function were determined.Results; After treatment, the levels of TNF-α, IL-6 and NO were significantly lower than those before treatment (P<0.05, or P<0.01) in the two groups, and the lowering degree of the indices in the trial group was more significantly reduced than that in the control group (P<0. 05). And cardiac functions in both groups were improved significantly ({otP}<0. 05, orP< 0.01).Conclusion: JXD could prevent and reverse ventricular remodeling so as to ameliorate cardiac function through regulating the levels of cytokines.Keywords：congestive heart failure;interleukin-6;tumor necrosis factor-α;nitrogen monoxide;cardiac function;Jianxin decoction
- 795
- |
- 377
- |
- 1
Published：2021-08-27 - Abstract：Objective:To study the effect of Xiongshao Capsule (XSC), a TCM herb that can promote blood circulation to remove blood stasis, on the endothelial dependent relaxation function, serum nitric oxide (NO), and plasma endothelin-KET-1) of the patients with cervical atherosclerosis.Methods: Forty patients were randomly divided into two groups: XSC group and Probucol group (western medicine control). In addition, 20 healthy people were set as a normal control group. Plasma ET-1, serum NO, the internal diameter of basal brachial artery, endothelial dependent flow mediated dilation (FMD) and non-endothelial dependent nitroglycerin induced dilation (NID) to the trial group before and after therapy and to the healthy control group were determined respectively. Results: Compared to the healthy control group, FMD of patients with atherosclerosis was damaged obviously, the serum NO level decreased, plasma ET-1 increased (P< 0.01), NID also decreased (P<0.05), the internal diameter of basal brachial artery has no obvious difference (P>0.05). After the patients with atherosclerosis were treated with Xiongshao Capsule for 12 weeks, FMD increased evidently, plasma ET-1 decreased, serum NO and the ratio of NO/ET-1 increased, compared with the level before therapy and Probucol group, the difference was significant (P<0.05,P<0.01), NID didn’t change obviously (P>0.05).Conclusion: XSC could regulate vascular activity factor and improve the function of endothelial dependent vascular dilation of patients with atherosclerosis.Keywords：atherosclerosis;endothelial vasodilator function;Xiongshao capsule
- 795
- |
- 371
- |
- 5
Published：2021-08-27 - Abstract：Objective: To observe the clinical effect of Yiqi Huoxue, YQHX) herbs in treating the patients with chronic cor pulmonale and to explore its mechanism by determining the relationship of oxidation/antioxidation system and how such herbs change on the function of endothelial cells and platelets.Methods: Fifty-eight patients were divided into two groups: conventional therapy group (control group, 28 patients) and convention plus YQHX herbs group (treated group, 30 patients). The control group received conventional management. The treated group were treated with YQHX 150 ml, twice a day, plus the conventional treatment, and the clinical efficacy was recorded. The lipid peroxidation (LPO), Superoxide dismutase (SOD), α-granule membrane protein (GMP140), partial pressure of arterial oxygen (PaO2), partial pressure of carbon dioxide in artery (PaCO2) and circulating endothelial cells (CEO were measured respectively before and after treatment, and the relationship between various parameters were analyzed. The results were compared with those of 10 healthy subjects got at the same period.Results: (1) The effective rate and PaO2 of the treated group was higher than that of the control group and there were no difference in PaCO2 between the two groups. (2) The levels of LPO, GMP140, CEC in all the patients before therapy were significantly higher than those of the healthy group, and there were marked decrease in the levels of those after treatment (all P<0.01). On the contrary, the levels of SOD in all the patients before therapy were markedly lower than those in the healthy subjects and increased after treatment, P<0.01. (3) The increase of SOD in the treated group was significantly more obvious than that of the control group. In the treated group, the decrease of LPO, GMP140, CEC were markedly more obvious than those in the control group (all P<0. 01). (4) The number of CEC, as well as GMP140, was negatively correlated to PaO2 (P<0.01) and SOD (P< 0.01), which was positively correlated to LPO (P<0.01). There was a positive correlation between CEC and GMP140 (P<0.05).Conclusion: YQHX herbs in treating chronic cor pulmonale proved to be effective by balancing the oxidation and antioxidation, protecting the pulmonary endothelial cells and activated platelets and helpful in treating respiratory failure.Keywords：chronic cor pulmonale;Yiqi Huoxue herbs;free radical damage;vascular endothelium;α-granule membrane protein
- 721
- |
- 369
- |
- 0
Published：2021-08-27 - Abstract：Objective: To explore the clinical efficacy of Xuefu Zhuyu, XFZY) oral liquid combined with western medicine (WM) in reversing left ventricle remodeling (LVR) after acute myocardial infarction (AMI) in patients and its therapeutic mechanism.Methods: Sixty patients conforming to criteria were divided into the treated group and WM control group with randomly stratified method. Thirty cases were assigned to each group, they were given XFZY + WM + general treatment and WM + general treatment respectively. Color Doppler ultrasonography was used to study the changes of LVR before and after treatment. Results: In both groups, before and after treatment theP value of such parameters as the changes of their left diastolic volume (LDV), left systolic volume (LSV), left ventricle ejection fraction (EF) was <0.05, suggesting that the difference of various parameters was significantly different; but when compared with the results of the 12th week after medications, the change of LDV, LSV, EF showed that the LDV, LSV of the treated group were lower than that of the control group, the EF of the treated group was higher than that of the control group, and theP value of various groups was all <0.05, suggesting that the different data of various groups showed significant difference.Conclusion: Conventional WM treatment and XFZY combined with WM could both, in treating AMI, effectively reverse the patients’ LVR; yet the use of integrative Chinese and western medicine on reversing patient’s LVR showed even better results than that of simple WM treatment.Keywords：Xuefu Zhuyu oral liquid;left ventricle remodeling;ultrasonography
- 823
- |
- 357
- |
- 1
Published：2021-08-27 - Keywords：Total Effective Rate;Medopa;Left Ventricle Remodel;Scavenge Oxygen Free Radical;Acute Coronary Artery
- 33
- |
- 0
- |
- 0
Published：2021-08-27 - Abstract：Objective: To observe the effect of Astragalus Injection (Al) on levels of blood selenium (Se) and cytokines, and T cellular immune function with viral myocarditis (VM) in children.Methods: Eighty children with VM were randomly divided into 2 groups. The control group consisted of 38 patients, to whom conventional therapy, including energy mixture, vitamin C and coenzyme Q10, etc. were given. The treated group (n = 42), to whom combination therapy of conventional therapy and Al were given. The levels of blood Se and cytokine, including interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and also evaluation of T lymphocyte subsets and cardiac function were observed.Results: The results showed that after treatment, the levels of blood Se were significantly higher (P<0. 01), while IL-1, IL-6 and TNF-α were significantly lower (P<0.01) than those before treatment in the control group. The left ventricular end diameter (LVED) were significantly decreased (P<0.01), left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were significantly increased than those before treatment in the treated group(P<0.01, P<0.05). T lymphocyte subsets got normalized (P<0.01), and compared with the control group, the difference was significant (P<0.01).Conclusion: Astragalus membranaceus possesses anti-viral effect, adjusts the balance of cytokine and T cellular immunity, and improves the clinical manifestation and cardiac function. It is an effective approach in treating viral myocarditis.Keywords：Astragalus Injection;Viral Myocarditis;selenium;immunity
- 748
- |
- 356
- |
- 3
Published：2021-08-27 - Abstract：Objective: To investigate the effects of Shenqi Fuzheng injection SQFZI) on ventricular remodeling (VR) after acute myocardial infarction (AMI).Methods: Sixty patients with AMI were randomly divided into two groups and received conventional therapy and conventional therapy plus SQFZI separately. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-9 (TIMP-9) in plasma was measured on the 1st and 14th days after AMI.Results:MMP-9 andMMP-9/TIMP-9 were increased after AMI, after 2-week treatment, the level ofMMP-9 andMMP-9/TIMP-9 decreased more significantly in SQFZI group than that in the conventional group (P<0.05).Conclusion; Early treatment with SQFZI after AMI could reduce the level of MMPs and the production of collagen. It may be useful for the prevention of VR and heart failure after AMI.Keywords：matrix metalloproteinase;acute myocardial infarction;ventricular remodeling;Shenqi Fuzheng injection
- 783
- |
- 392
- |
- 1
Published：2021-08-27 - Abstract：Objective: To explore the effect of Shenfu Injection, SFI) on the secondary aplastic anemia (AA) of tumor patients after chemotherapy (CT).Methods: The 15 cases of SFI treated group, 10 cases of control group, 25 cases of SFI + granulocyte-macrophage colony stimulating factor (GMCSF) treated group and the group of 23 GM-CSF-treated tumor cases of secondary AA after CT were compared, with their increasing rate and the rebound speed of neutrophil, platelet, bone marrow nucleated RBC, granulocyte, and megakaryocyte all being investigated.Results: The increasing rate and rebound speed of granulocyte, platelet, and the increasing rate of bone marrow nucleated RBC, granulocyte, megakaryocyte were obviously higher than those of the control, and the clinical manifestations were also obviously improved. The increasing rate of platelet, bone marrow nucleated RBC, megakaryocyte of the SFI + GM-CSF group were higher than those of the group which used GM-CSF alone, while the increasing rate of granulocyte in blood and bone marrow in both groups was similar.Conclusion: Significant efficacy was shown in SFI for the treatment of secondary AA of tumor patients after CT.Keywords：Shenfu Injection;secondary;aplastic anemia;Therapeutic Effect
- 701
- |
- 400
- |
- 0
Published：2021-08-27 - Abstract：Objective: To investigate the effects of baicalin on expression of inducible nitric oxide synthase (iNOS) in fibroblasts and its mechanisms in treating psoriasis.Methods: Fibroblasts cultured in vitro were stimulated with tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-8 (IL-8) in different groups. iNOS was detected by western blot and immunocytochemistry assay, and in addition, the effects of baicalin on its expression were investigated.Results: Fibroblasts did not express iNOS without cytokine stimulation. When treated for 24 h with 1.0 × 106U/L TNF-α, 0.2 × 106U/L IFN-γ, 0.2 × 106 pg/L IL-8 alone or in combinations indicated, fibroblasts produced iNOS when stimulated by TNF-α alone while neither IFN-γ nor IL-8 could induce the production of iNOS. The combination of TNF-α and IL-8 induced a strong expression of iNOS, the combined exposure of three kinds of cytokines showed an even stronger effects. The strongly stained area was in the cytoplasm near the nuclei. Expression of iNOS induced by TNF-α and IL-8 was inhibited by 50 μg/ ml of baicalin.Conclusion: Fibroblasts might express iNOS when stimulated by certain cytokines. Baicalin decreased production of nitric oxide through inhibiting the expression of iNOS, furthermore it reduced inflammation, which might be part of its mechanisms in treating psoriasis.Keywords：Baicalin;fibroblasts;inducible nitric oxide synthase
- 797
- |
- 418
- |
- 0
Published：2021-08-27 - Keywords：psoriasis;Dermal Fibroblast;Baicalein;Baicalin;Wogonin
- 31
- |
- 0
- |
- 0
Published：2021-08-27 - Abstract：Objective: To investigate the effects of ligustrazine (Li) on myocardial fibrosis in rats with pressure overload.Methods: Pressure overload rat models were established by constricting the abdominal aorta. Sixty-three SD rats were divided into 3 groups: Sham operated group (SOG, n = 21), operated group (OG,n = 21) and operated combined with ligustrazine group (OG+Li,n = 21). Each group was randomly assigned to seven time points: The 1st, 2nd, 4th, 7th, 14th, 21st and 30th day after operation. Three rats were included in each time point. Serial sections of cardiac tissues were examined and the morphological or morphometric analysis of the SOG, OG and OG+Li done by histopathological and computer image analyzer technique.Results: (1) It showed that there were reactive fibrosis (from the 4th day on after operation) and reparative fibrosis (from the 21st day on after operation) in the OG, while myocardial fibrosis in the OG+Li was alleviated. Though reactive fibrosis (from the 21st day on after operation) was shown, reparative fibrosis wasn’t seen. (2) Perivascular collagen area (PVCA) in the OG (2. 09 ± 0. 45) was significantly higher than SOG (0.83 ± 0.06) from the 1st day on after operation and then steadily increased, while in the OG+Li (1.16 ± 0.06), it was significantly lower than OG at the same time; collagen volume fraction (CVF) in the OG (3.08 ± 0. 56) significantly increased compared with the SOG (2. 78 ± 0. 64) from the 2nd day on after operation and showed a trend of rapid ascending from the 21st day on after operation; and in the OG + Li (4.69 ± 0.85), it was significantly decreased compared with the OG (7.56 ± 0.88) from the 21st day on after operation, with allP<0. 05.Conclusion: Ligustrazine could alleviate and postpone the accumulation of myocardial collagen and has protective effects on the heart.Keywords：Ligustrazine;pressure overload;myocardial fibrosis
- 675
- |
- 399
- |
- 0
Published：2021-08-27 - Abstract：Objective: To observe the effects of arsenic trioxide (As2O3) on human renal cell carcinoma (RCC) lines in vitro and to explore its possible molecular mechanisms.Methods: The microculture tetrazolium (MTT) assay was used to determine the anti-proliterative effects of As2O3 on human RCC lines. Flow cytometry was performed to investigate the effects of As2O3 on cell cycle and cell apoptosis. The reverse transcription-polymerase chain reaction (RT-PCR) was conducted to detect mRNA expression of Bcl-2, Bax, p53 and c-myc.Results: As2O3 inhibited the growth of RCC lines in vitro in a concentration-dependent manner. At the concentrations of 0.5, 1.0, 2.0 and 4. 0 μmol/L, the inhibition rates of As2O3 on RCC-WCS cells were 27.60%, 30.09%, 41.03% and 50.77%, respectively. Compared with untreated RCC-WCS, there was significant difference at each concentration (P<0.01). As2O3 induced a G1 phase arrest in RCC-LSL cells, but a G2/M phase arrest in RCC-WCS and RCC-SHK. As2O3 induced cell apoptosis in these cell lines. The mRNA level of p53 and c-myc decreased, but no detectable changes of Bcl-2 and Bax were observed after As2O3 treatmen.Conclusion: As2O3 in therapeutic concentrations inhibited the in vitro growth of RCC lines via cell cycle arrest and apoptosis. One of its possible mechanisms was down-regulation of p53 and c-myc. Our results suggest that As2O3 is probably a new candidate agent for the treatment of human renal carcinoma.Keywords：renal cell carcinoma;Arsenic Trioxide;apoptosis;cell cycle arrest
- 810
- |
- 379
- |
- 1
Published：2021-08-27 - Keywords：Arsenic;Arsenic Trioxide;Methimazole;Arsenic Compound;Ovarian Carcinoma Cell Line
- 24
- |
- 0
- |
- 0
Published：2021-08-27 - Abstract：Objective: To examine the effect of Yuxingeng fluid, YXGF) on myocardial energy metabolism in Wistar rats with acute myocardial infarction (AMI) by observing the ultrastructure of mitochondria and the enzyme activities of rat myocardial adenosine triphosphate (ATP), succinate dehydrogenase (SDH), acid phosphatase (ACP), alkaline phosphatase (ALP) and the content of glycogen.Methods: AMI models were established by ligature of left anterior descending coronary artery and then the rats with AMI were randomly divided into 7 groups: namely, blank group, model group, sham-operated group, captopil group, high-dose YXGF group, middle-dose YXGF group and low-dose YXGF group. From the next day after modeling, the rats were given YXGF through gastrogavage which lasted for 4 weeks. And then, the ultrastructure of mitochondria was observed by electronic microscope and the enzyme activities of ATP, SDH, ACP, ALP and the content of glycogen were determined.Results: Compared with model group, the other three groups of high-dose YXGF, middle-dose YXGF, low-dose YXGF and captopril group could protect the ultrastructure of mitochondria and significantly increase enzyme activities of ATP, SDH, ACP, ALP and the content of glycogen (P<0.01).Conclusion: YXGF can protect mitochondria and increase myocardial enzyme activities and the content of glycogen, which may be one of the mechanisms intervening in the pathological course of the early ventricular remodeling in rats with AMI.Keywords：Yuxingeng fluid;acute myocardial infarction;myocardial energy metabolism
- 768
- |
- 402
- |
- 0
Published：2021-08-27 - Abstract：Objective: To investigate the effect of Buzhong Yiqi decoction, BZYQD) on liver damage induced by food allergy in mice.Methods: Nc/Jic strain mice with high levels of serum IgE were sensitized by ovalbumin (OVA), and then divided into two groups and respectively treated with BZYQD (treated group) or normal saline (model group). Samples of serum, liver tissues and small intestine were collected two weeks later, and another group of non-sensitized mice was set as the normal group. The levels of serum alanine aminotransferase (ALT) were measured with spectrophotometry. The liver tissue and small intestine were stained with hematoxylin and eosin (HE) for pathologic analysis. The liver samples were also subjected to analysis of CD4-T helper cell and cytokine (interleukin-4, IL-4, interleukin-6, IL-6) expression with immunohistochemical (avidin-biotin complex, ABC) method.Results: Serum ALT levels decreased and obvious pathologic improvements were seen in the mice treated with BZYQD. And compared with the model mice, the number of positive cells of IL-4, IL-6 and CD4 cell decreased significantly in those treated with BZYQD.Conclusion: BZYQD can effectively decrease the production of cytokines associated with allergic reaction in the liver of mice thus effective in treating liver damage caused by food allergy.Keywords：food allergy;Liver Damage;Buzhong Yiqi decoction
- 796
- |
- 370
- |
- 1
Published：2021-08-27 - Keywords：Warfarin;International Normalize Ratio;Atrial Fibrillation Patient;Rheumatic Heart Disease;Congestive Heart Failure Patient
- 752
- |
- 368
- |
- 1
Published：2021-08-27 - Keywords：Atrial Fibrillation;Creatine Kinase;Congestive Heart Failure Patient;Chronic Congestive Heart Failure;acute cerebral infarction
- 32
- |
- 0
- |
- 0
Published：2021-08-27 - Keywords：hyaluronic acid;Hepatic Fibrosis;Apricot Kernel;Chronic Hepatic Disease;Western Medicine Group
- 767
- |
- 378
- |
- 2
Published：2021-08-27 - Keywords：Saponin;Glycyrrhizic Acid;Hyoscyamine;amygdalin;Hydrocyanic Acid
- 907
- |
- 389
- |
- 0
Published：2021-08-27 - Keywords：Blood Stasis;Standard Nomenclature;Blood Disorder;Complex Term;Abdominal Colic
- 781
- |
- 393
- |
- 0
Published：2021-08-27 -
- Keywords：Vascular Remodel;Emodin;Ligustrazine;Tetrandrine;Activate Blood Circulation
- 816
- |
- 357
- |
- 0
Published：2021-08-27 - Keywords：Vascular Smooth Muscle Cell;Vascular Dementia;Tetrandrine;Coronary Artery Intervention;Coronary Restenosis
- 34
- |
- 0
- |
- 0
Published：2021-08-27 - Keywords：Melatonin;Passive Avoidance;Maximal Life Span;Free Radical Theory;Aged Garlic Extract
- 700
- |
- 365
- |
- 3
Published：2021-08-27
- Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
- Tel：010-62886827, 62877592 Fax：010-62874291
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
0