Latest Issue
Vol. 12 ， Issue 3 ， 2006
- Abstract：Integrative medicine (IM), usually called integrated traditional and Western medicine in China, which came into being in the 1950s as a new form of medicine, although is now developing quickly, little is known about its status and existing problems. So a national survey in China was conducted through questionnaire in 2004 by Chinese Association of Integrative Medicine with the support of State Administration of Traditional Chinese Medicine (SATCM). The results show that, of all the medical professionals investigated in this survey, 91.21% and 93.52% respondents respectively favored IM as the best diagnostic and therapeutic method. Of all the patients who once went through TCM, Western medicine (WM) and IM therapies, 68.85%, 65.45% and 71.2% respondents respectively most appreciated IM, IM hospitals and IM therapeutic treatments. Most of the 6 595 respondents held that the optimal scientific research strategy in TCM should be integrating modern medical research method (n = 2 380) or modern scientific method (n = 2 920). However, many hospitals exposed the problems in the aspects of governmental supports and funding supports, human resources, and domestic or international academic activities. These results indicated that IM is the patients’ social needs and doctors’ aspiration in China. For further development of IM, the enhancement of scientific research construction and assistance by policies and finance from the government and other institutions are urgently needed in China.Keywords：Integrative Medicine;survey;China
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Published：2021-08-27 - Abstract：Objective: To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque (CAAP) in patients with primary hypertension and coronary heart disease (PHT-CHD).Methods: Seventynine patients with PHT-CHD were randomly divided into the treated group (39 patients) treated with garlicin and fosinopril and the control group (40 patients) treated with fosinopril alone. The change of CAAP was evaluated by high frequency ultrasonic examination every six months, and the changes of intercellular adhesion molecule-1 (ICAM-1) and high sensitive C-reactive protein (hs-CRP) were measured by ELISA, with the observation proceeding for 52 weeks totally.Results: By the end of the experiment, the number of complex plaques, Crouse integrals, intima-media thickness, serum ICAM-1 and hs-CRP were significantly lower in the treated group than those in the control group with significant difference (P < 0. 05).Conclusion: Garlicin could stabilize CAAP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD.Keywords：garlicin;primary hypertension;coronary heart disease;Atherosclerotic Plaque;intercellular adhesion molecule-1;high sensitive C-reactive protein
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Published：2021-08-27 - Abstract：Objective: To evaluate the therapeutic effects of Quyu Xiaoban Capsule, (QYXBC) on endothelial dependent vascular relaxation (EDVR) function in patients with atherosclerosis (AS) with ultrasonic technique.Methods: Tested were the endothelial function and blood lipids of 42 patients with AS in the treated group and 30 healthy volunteers in the control group. And re-examination of these parameters was carried out on the AS patients after they had been treated with QYXBC for 10 months.Results: Before treatment, the reactive hyperemia induced changes in artery diameter in the treated group was significantly lower than that in the control group (P < 0.01), while insignificant difference was found between the two groups in response to nitroglycerin. In the treated group after treatment, with D%-R improved significantly (P < 0.01), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) decreased by 16.3%, 5.6%, 10.2% respectively and high-density lipoprotein cholesterol (HDL-C) increased by 7.5%. EDVR was correlated negatively with the serum TC, LDL-C concentrations and the baseline brachial diameter (D0 (r = -0.41, -0.66, -0.59, respectively, allP < 0.01), but correlated positively with HDL-C (r = 0.62,P < 0.05). The ameliorative extent of EDVR was correlated positively to the decreased magnitude of TC and LDL-C concentrations (r = 0.67,0.59, bothP < 0.01).Conclusion: QYXBC can lower the level of blood lipids and improve significantly EDVR function.Keywords：Quyu Xiaoban Capsule;atherosclerosis;endothelial function
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Published：2021-08-27 - Abstract：Objective: To explore the effect and possible mechanism of traditional Chinese medicine (TCM) on survival and quality of life (QOL) in patients with esophageal carcinoma after esophagectomy.Methods: Adopting prospective controlled method of study, the authors had 128 post-esophagectomy patients, hospitalized from February 2001 to February 2002, randomly divided into 3 groups: the TCM group, treated with TCM drugs alone; the chemotherapy group, with chemotherapy alone applied; and the synthetic group, treated with chemotherapy combined with Chinese medicine. Their survival rate and QOL were compared.Results: In the TCM group, the chemotherapy group and the synthetic group, the respective 3-year relapse and remote metastasis rate were 71.4%, 76.7%, 53.4%, respectively (x2 = 6.53,P < 0.05); the 1-year survival rate 42.9%, 46.5%, 72.1 %; 2-year survival rate 28.6%, 27.9%, 55.8%, and 3-year survival rate 26. 2%, 23. 1%, 37. 2%, respectively. And the QOL improving rate was 69. 0%, 37. 2%, 58.1%, respectively, all showing significant difference among them (x2 = 6. 10, allP < 0.05). Moreover, immune function was increased in the TCM and the synthetic groups.Conclusion: Integrative Chinese and Western medicinal treatment was the beneficial choice for post-operational patients with esophageal carcinoma. However, long time use of simple Chinese medicine was also advisable, especially for those in poverty.Keywords：post-esophagectomy;traditional Chinese drug therapy;quality of life;Survival Rate
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Published：2021-08-27 - Abstract：Objective: To investigate the analgesic effects of Nourishing yin and Unblocking meridians Receipe (NUR) combined with opioid analgesics in managing cancer pain.Methods: All the patients enrolled were differentiated as of yin deficiency and meridian blocked syndrome type of TCM. Forty-one of them in the treated group were treated with NUR combined with opioid analgesics, while 43 of them in the control group were given opioid analgesics alone with successive 14 days as one treatment course for both groups.Results: The indexes of the treated group were superior to those in the control group as to the degree of pain-relieving, the therapeutic effect of analgesia, the occurrence frequency of cancer pain every day and its duration each time, the analgesic initial time, and the quality of life.Conclusion: NUR combined with opioid analgesics in cancer pain management was more effective than opioid analgesics alone.Keywords：malignant tumor;pain;opioid;analgesic;Nourishing yin and Unblocking meridians Recipe;Clinical Observation
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Published：2021-08-27 - Abstract：Objective: To observe the levels of serum C-reactive protein (CRP), endothelin-1 (ET-1), nitric oxide (NO), and superoxide dismutase (SOD) in patients after intracoronary stenting (ICS), and the effects of Erigeron Injection (EI) on them.Methods: Seventy-two patients, who received ICS and had symptoms of chest stuffiness, palpitation and chest pain, were randomly divided into two groups, with 36 patients in the control group treated with Plavix alone for anti-platelet aggregation, and the other 36 patients in the treated group treated with Plavix and EI in combination. CRP, ET-1, NO and SOD were determined and compared before and 1, 2 and 3 weeks after treatment.Results: As compared with those in the control group, improvement of symptoms in the treated group was significantly better, with the levels of CRP and ET-1 lower and levels of SOD and NO higher or approaching to normal ranges and significant difference was shown between the two groups (P < 0.01).Conclusion: EI could alleviate uncomfortable feelings such as chest stuffiness in patients after ICS, and improve the function of vascular endothelium.Keywords：after intracoronary stenting;endothelin;C-reactive protein;superoxide dismutase;Nitric Oxide;Erigeron Injection
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Published：2021-08-27 - Abstract：Objective: To study the effect of Chinese herbal medicine Gutai Decoction (GTD) on the abortion rate ofin vitro fertilization and embryo transfer (IVF-ET).Methods: Observed were two hundred and forty-seven women having received IVF-ET and with β-human chorionic gonadotropin (β-HCG) > 25 IU/L on the 14th day after transferring. All were treated conventionally with progesterone 20 –80 mg per day after transferring and if necessary the treatment was supplemented with Progynova 2 –4 mg per day, with the medication withdrawn gradually from the 9th week of pregnancy till stopped completely. Among them 131 cases received GTD medication additionally, for 109 cases of whom the medication started from the 2nd day of transferring (taken as Group A) and for the other 22 cases from the 14th day after transferring (taken as Group B), the other 116 cases with no additional GTD treatment given were taken as the control group, with the medication lasting to the 12th week. The abortion rate in them was observed.Results: The abortion rate in Group A, Group B and the control group was 12.84%, 13.64% and 23.28%, respectively, the difference between the GTD treated groups and the control group was significant (P < 0.05).Conclusion: Chinese medicine GTD could reduce abortion rate in women receiving IVF-ET.Keywords：in vitro fertilization;abortion rate;Chinese medical therapy;Gutai Decoction
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Published：2021-08-27 - Abstract：Objective: To evaluate the effects of Xinlikang (XLK) on angiotensin II (Ang II) induced hypertrophic cultured neonatal rat’s cardiomyocyte (CMC).Methods: Primary cultured neonatal rat’s CMCs with the purity certified by immunohistochemical technique, were divided into three groups. Rats in the normal control group were untreated;those in the model group were established into hypertrophic models but underwent no treatment;and those in the XLK group were established to hypertrophic models and treated with XLK containing serum obtained from rats with aorta coarctation after 8 days of feeding with XLK. MTT and phase-contrast microscope were used to evaluate the effect of XLK on cell activity, pulsating rhythm and surface area;Atrial natriuretic peptide (ANP) expression was determined by radioimmunoassay; Protein content was determined by Bradford method;and DNA synthesis was detected by flow cytometric assay.Results: Immunohistochemistry results showed that more than 90% of the cells were α-sarcometin actin stained positive cells. No significant effect of XLK on normal CMC was found. Ang II could significantly induce hypertrophy in CMCs, and XLK could significantly decrease the increased surface area and the accelerated pulsating rate in them. ANP expression was 780 ±38 μg/L in the model group, and 430 ±23 ώg/L in the control group, and the elevated expression of ANP in model rats was significantly decreased in the XLK group;The DNA content in the G0/G1 and G2/M phases was significantly enhanced and at the same time i was accompanied with increase of total protein content in the model rats after being stimulated by Ang II for 24 h, showing that serum-containing XLK could also significantly suppress total protein synthesis (P < 0. 05).Conclusion: XLK could improve Ang II mediated pathological growth of CMCs without influencing the growth of normal CMCs, suggesting that XLK is probably an effective drug for treatment of myocardial hypertrophy and heart failure.Keywords：Xinlikang;angiotensin II;cardiomyocyte;hypertrophy
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Published：2021-08-27 - Abstract：Objective: To investigate the cardio-protective effects of Corocalm on acute myocardial ischemia in rats, and to explore its possible therapeutic mechanisms.Methods: The acute ischemic model was prepared by ligating the left anterior descending (LAD) coronary artery in rats. The animals were divided into 6 groups, 8 in each group. The sham operated group underwent heart exposure without ligation and were treated with normal saline 3 ml/kg, while the other 5 groups, the model groups, consisted of acceptable acute ischemic model rats and were also treated with normal saline, with the Guanxin Capsule (GXC) group treated with refined GXC, 600 mg/kg, the low and high dose Corocalm groups treated with 85 mg/kg and 340 mg/kg of Corocalm respectively, and the Diltiazem group, treated with Diltiazem 5 mg/kg, with all the tested drugs prepared with normal saline into equal volume (3 ml/kg) and administrated once via duodenum 10 min before ligation. Myocardial infarction area was determined by the quantitative histological assay with nitroblue tetrazolium (N-BT) stain. And the levels of creatine phosphokinase (CK), lactate dehydrogenase (LDH), malondialdehyde (MDA) content, and the activity of superoxide dismutase (SOD) in serum were measured by biochemical assay and spectrophotometry respectively. Besides, the blood viscosity in another 50 rats was determined, who received for 7 successive days oral administration with different concentration of Corocalm or aspirin.Results: It showed that low and high dose Corocalm could significantly reduce the infarction area, inhibit the increase of serum CK, LDH activity and MDA content, and enhance the SOD activity after ischemia/reperfusion. The whole blood viscosity at different shear rates in rats treated with high dose Corocalm was significantly lower than those treated with normal saline (P < 0.05).Conclusion: Corocalm has favourable protective effects on heart in ischemic condition, the effect of which might be through its actions in inhibiting CK and LDH activity, scavenging oxygen free radicals, and lowering blood viscosity.Keywords：Corocalm;acute myocardial ischemia;oxygen free radicals;Blood Viscosity;rats
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Published：2021-08-27 - Abstract：Objective: To investigate the neuro-protective effect of Xuesaitong Injection XST on brain inflammatory response after transient focal cerebral ischemia/reperfusion in rats.Methods: Focal cerebral ischemia/reperfusion models of male rats were induced by transient occlusion for 2 h of middle cerebral artery (MCA) which was followed by 24 h reperfusion. XST was administered through intraperitoneal injection of 25 mg/kg or 50 mg/kg at 4 h after the onset of ischemia. After reperfusion for 24 h, the neurological function score was evaluated, the brain edema was detected with dry-wet weight method, the myeloperoxidase (MPO) activity and the expression of intercellular adhesion molecule-1 (ICAM-1) of ischemic cerebral cortex and caudate putamen was determined by spectrophotometry and immunohistochemistry respectively.Results: XST not only lowered neurological function score at the dose of 50 mg/kg, but reduced brain edema and inhibited MPO activity and ICAM-1 expression as compared with the ischemia/reperfusion model group (P < 0.01).Conclusion: XST has a definite effect on inhibiting the expression of ICAM-1 and neutrophil infiltration in rats with cerebral ischemia/reperfusion when treatment started at 4 h after ischemia onset, and also attenuates inflammation in the infarcted cerebral area.Keywords：Xuesaitong Injection;total saponins of panax notoginseng;Cerebral Ischemia;brain injury;neutrophil;intercellular adhesion molecule-1
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Published：2021-08-27 - Abstract：Objective: To study the effect of salvianolic acid B (SAB) and curcumin, the extracts ofSalvia Miltiorrhiza andCurcuma Longa, on the proliferation and activation of hepatic stellate cell (HSC), and the extracellular signal regulated kinase (ERK) expression in it.Methods: Rat’s HSC-T6 were cultured and treated by SAB or curcumin. The inhibitory effect on cell proliferation was determined by 3-(4,5-dimthyl-2-2-thiazoly)-2,5-diphenyl-2H-tetrazolium bromide (MTT) colorimetry, and the expression levels of α smooth actin (α-SMA), collagen type I, and ERK were determined by Western blot.Results: SAB and curcumin inhibited the proliferation and activation of rat’s HSC-T6 in dose-dependent fashion and significantly reduced the expression level of a-SMA (P < 0.01). Curcumin significantly reduced the expression of collagen type I (P < 0.05). Both SAB and curcumin showed insignificant effect on the ERK expression level, but they could significantly reduce the level of phosphorylated-ERK expression, showing significant difference as compared with that in the control group (P < 0. 01 andP < 0. 05 respectively).Conclusion: SAB and curcumin could significantly inhibit the proliferation, activation of HSC, and the production of type I collagen in HSC, the mechanism may be associated with their inhibition on ERK phosphorylation.Keywords：salvianolic acid B;Curcumin;extracellular signal regulated kinase;phosphorylation
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Published：2021-08-27 - Abstract：Objective: To study the therapeutic effect of treatment of acute gouty arthritis (AGA) respectively by electroacupuncture (EA) with different frequency and oral intake of Western medicine.Methods: Seventy-two patients of AGA were randomly assigned into three groups, 24 in each group. Group A was treated with EA 100 Hz;Group B with EA 2 Hz;and Group C with Western medicine. The analgesic effect, initiating time and sustaining time of analgesia were observed and the level of serum uric acid was measured before and after treatment.Results: The initiating time of analgesia was shorter while the sustaining time of analgesia was longer in Group A and B than those in Group C (allP < 0. 01). The efficacy of analgesia was higher in Group B than that in Group A, and a better effect was shown in Group B in reducing serum uric acid level than that in Group A (P < 0.01), which was near that in Group C (P > 0.05).Conclusion: EA is an effective treatment for AGA, and low frequency (2 Hz) EA showed a better efficacy.Keywords：electroacupuncture;Acute Gouty Arthritis;uric acid
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Published：2021-08-27 - Abstract：Objective: To observe the effect of Kaixin Capsule (KXC) on myocardial ischemia and plasma endothelin (ET) level in patients with diabetic heart disease (DHD).Methods: The 72 subjects for observation were randomly selected from inpatients whose diagnosis fit to the standard of DHD. The 32 patients allocated in the control group were treated with conventional Western medicine, and the 40 patients in the treated group were treated with conventional Western medicine in combination with KXC, with the therapeutic course for both groups as 60 days.Results: On ECG, the total effective rate and markedly effective rate in the treated group was 85. 0% and 37. 5% respectively, higher than those in the control group’s 68.7% and 28.1% respectively, and showing significant difference between the two groups (P < 0.05). The level of ET in patients in both groups was significantly higher than normal range, after treatment, but reduced to different extent, and the comparison between them also showed that the difference was significant (P < 0.05).Conclusion: KXC might, by way of inhibiting and blocking the release of ET, lower its level in plasma so as to improve the myocardial ischemic condition of patients with DHD.Keywords：diabetic heart disease;Myocardial ischemia;endothelin;Kaixin Capsule
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Published：2021-08-27 - Abstract：Objective: To observe the clinical efficacy and safety of Yiweining, (YWN) and gestrinone (GT) in treating post-operational patients of stage III endometriosis (EM-III).Methods: Fifty-two patients of EM-III after operation were randomly assigned into three groups, the YWN group (20 patients) was treated through oral intake of YWN 200 ml, twice a day;the GT group (19 patients) treated with gestrinone 2.5 mg, twice every week, with the medication starting from the 7th post-operational day and lasting for 6 months. The control group (13 patients) was untreated. Six months was one therapeutic course, and follow-up study was carried out in the 6 –30 months after the end of the medication.Results: The recurrence rate in the YWN group and the GT group were 5.0% and 5.3% respectively, showing insignificant difference between the two groups, but they were lower than that in the control group (30.7%,P < 0.05). Besides, the adverse reaction rate in the YWN group was lower than that in the GT group (10.0% vs 31.6%,P < 0.05).Conclusion: Application of YWN to prevent the post-operational recurrence of endometriosis is effective and safe, and its efficacy is similar to that of GT.Keywords：endometriosis after operation;Yiweining;gestrinone
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Published：2021-08-27 - Abstract：Objective: To study the effect of Simotang oral liquid and glycerin enema on the patients’ bowel sound (BS) restoration and anal exhaust after abdominal gynecological operation.Method: Ninety patients with benign tumor who had undergone gynecological operation were randomly divided into the Simotang group, treated after operation with Simotang oral liquid;the enema group, treated with glycerin enema, and the control group, non-treated. The restoration time of BS and anal exhaust were observed.Results: Compared with the control group, the restoration time of BS and anus exhaust were both significantly shorter in the Simotang group and the enema group, showing statistical significance (P < 0. 05); but the difference between the two treated groups was insignificant (P > 0.05).Conclusion: Simotang oral liquid and glycerine enema both could benefit the restoration of anal exhaust and BS after abdominal operation.Keywords：abdominal operation;Simotang oral liquid;glycerine enema;anal exhaust;Chinese Herbal Medicine
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Published：2021-08-27 -
- Abstract：This paper strongly rejects the notion that the use of biomedical terms to represent traditional Chinese medical concepts is helpful to the internationalization of Chinese medicine. It further argues that this practice destroys the integrity and independence of Chinese medical concepts. Taking the term fēng hu< o y < an as an example, it shows that the biomedical term “acute conjunctivitis” often suggested as the translation for this term is unsatisfactory, because (1) the clinical reference is not identical, (2) it introduces the concepts of “conjunctiva” and “inflammation”, which are not Chinese medical concepts, and (3) destroys the Chinese medical concepts “wind” and “fire” expressed in the Chinese, which reflect the way the disease is traditionally diagnosed and treated. While for English readers not familiar with Chinese medicine, “acute conjunctivitis” may be immediately intelligible, for those seeking a deep understanding of the subject, the literal translation (loan translation) “wind-fire eye” is much more helpful. This paper supports these arguments with numerous other examples.Keywords：biomedicized translation;Literal Translation;loan translation
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Published：2021-08-27 - Abstract：The repairing and regeneration of peripheral nerves is a very complex biological and cytological process, its mechanism is unclear so far, and thus results in the lack of specific and effectual therapy and medicament. Chinese herbs and their effective components have their own inimitable predominance in promoting peripheral nerve regeneration, such as their multi-factorial, multi-target and multi-functional action, abundant source, inexpensive, etc. In this paper, the experimental studies reported in recent 5 years concerning the effects of Chinese herbs or their active components on peripheral nerve repairing and regeneration are reviewed in respects of the integral level, cellular level, molecular level and gene level.Keywords：nerve regeneration;peripheral nerve;Chinese medicinal herbs
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Published：2021-08-27 - Abstract：Progress made over the pharmaceutical mechanism and clinical application ofGinkgo Biloba extract (GBE) on various kinds of diseases were reviewed in this paper. The effective elements contained in GBE are mainly kinds of Ginkgo flavonoid and Ginkgolide, which have marked protective effects on cardio-cerebral vascular and central nerve systems. In clinical practice, it is applied mostly in treatment of cardio-cerebral vascular diseases. Also it shows apparent effects in the treatment processes of some other diseases as an adjuvant, and therefore, has been gradually accepted by the medical circle in the world, proving to be a medicine of wide prospect in development and application.Keywords：Ginkgo leaf extract;pharmaceutical mechanism;clinical application;progress of research
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Published：2021-08-27
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