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      2005 Year 11 Vol. 1 Issue

        OriginalPaper

      • Xu Lie-ming,Jia Ji-dong
        2005, 11(1): 1-4. DOI: 10.1007/BF02835739
        Keywords：Traditional Chinese Medicine;Chinese Herbal Medicine;Herbal Product;Treat Liver Disease;Beijing Friendship Hospital   
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      • Shen Wei-sheng,Yang Hong-zhi,Hong Qi,Zhang Yong-qiang,Xie He-ping,Bian Zhuang
        2005, 11(1): 5-10. DOI: 10.1007/BF02835740
        Abstract：Objective:To evaluate the clinical efficacy of Ganxian recipe (GXR) and lamivudine (LVD) in a two-year treatment of chronic hepatitis B (CHB).Methods: One hundred and twenty patients with CHB were randomly divided into the combinedly treated group (combined group) of 40 CHB patients who were treated with GXR combined with LVD. Another 40 CHB patients were treated with LVD alone (WM group), and still another 40 CHB patients were treated with GXR alone (TCM group). All these cases were randomly controlled and observed for two years.Results: Comprehensive efficacy: Total effective rate of the combined group (complete response and partial response) was 92.5%, while that of the WM group was 67.5% and TCM group 57.5%, respectively, with the difference between them was significant (P<0.01); after treatment, the hepatic functions (AST, ALT, SB) of the three groups were all reduced, and the reduction in the combined group was particularly significant in comparison with the WM group or TCM group,P< 0.05 orP<0.01 respectively, suggesting that the effect in the combined group was better than that in the other two groups; the rate of tyrosine-methionine-aspartate-aspartate (YMDD) virus mutation: it was 7.5% in the combined group, 40.0% in the WM group, and 5.0% in the TCM group; liver fibrosis improvement parameter: after treatment, the results in the combined group got better than those in the other two groups.Conclusion: GXR could inhibit the appearance of YMDD after long-term application of LVD, and combined use has marked synergism.  
        Keywords：Ganxian recipe;Lamivudine;chronic hepatitis B;virus mutation;anti-viral treatment   
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      • Deng Yin-quan,Fan Xiao-fen,Li You-di
        2005, 11(1): 11-14. DOI: 10.1007/BF02835741
        Abstract：Objective: To study the effect of Xuesaitong soft capsule (XST) on liver fibrosis criteria in patients with post-hepatitis fibrosis.Methods: Sixty-four patients with such fibrosis were randomly divided into the treated group and control group. They were treated with XST and Dahuang Zhechong pill for 3 months respectively. Their liver fibrosis criteria were examined before and after treatment.Results: The levels of serum procollagen III, hyaluronic acid, collagen IV, laminin in the two groups were significantly lower (P<0. 01) than those before treatment. The differences between the two groups were insignificant (P>0.05).Conclusion: XST could recover liver dysfunction and had anti-liver fibrosis function.  
        Keywords：post-hepatitis fibrosis;procollagen III;hyaluronic acid;collagen IV;laminin;Xuesaitong soft capsule   
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      • Ji Wei,Zhu Xuan-xuan,Tan Wen-feng,Lu Yan
        2005, 11(1): 15-21. DOI: 10.1007/BF02835742
        Abstract：Objective: To observe the clinical effect of Rebixiao granule (RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXGs therapeutic mechanism.Methods: Ninety repeatedly attacking acute gouty arthritis patients were divided into the treated group (n = 60) and control group (n = 30). The treated group was treated with RBXG, and the control group was treated with Futalin tablets (diclofenac sodium). The baseline treatment including good rest, low purine diet, sufficient water drinking and urine alkalization, etc. was then given to both groups. Hypoxanthine 600 mg/kg and niacin 100 mg/kg was applied to hyperuricemic mice by gastrogavage to establish the animal models.Results: The clinical effective rate of the treated group was 95.0% and that of the control 90.0%. Good therapeutic effects were won, insignificant difference (P>0.05)was shown between the two groups. However, the cure rate of the treated group was 26.7% while that of the control group was 10.0%, with significant difference (P<0.01) shown between them. The treated group had its blood uric acid lowered, which was significantly different (P<0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages of RBXG, as well as the Ash bark and Smilax glabra rhizome groups had their blood uric acid content reduced in the hyperuricemic mice.Conclusion: RBXG has a quicker initiation and better treatment effects than sole anti-inflammatory and analgesic agents on the treatment of repeatedly attacking acute gouty arthritis, showing no obvious toxic or adverse reactions and therefore good for long-term administration and likely to be a safe TCM preparation to control the symptoms and reduce the onsets of repeatedly attacking of acute gouty arthritis. The animal experiment shows that both the compound preparation and part of the single ingredients in the recipe have the function of reducing blood uric acid. However, the compound recipe has better therapeutic effects, proving to be superior to single drugs.  
        Keywords：traditional Chinese medicine compound;repeatedly attacking;Acute Gouty Arthritis;treatment   
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      • Gu Xi-xi,Cai Ding-fang,Yang Yun-ke,Teng Ying,Chen Yi-ping,Wen Ming
        2005, 11(1): 22-26. DOI: 10.1007/BF02835743
        Abstract：Objective: To observe the therapeutic effect of Yangxue Qingnao granule (YXQNG) in treating chronic cerebrovascular insufficiency (CCI) and its possible mechanism.Methods: Eighty-three patients with CCI were randomly divided into YXQNG and nimodipine (ND) groups, the score of vertigo and the change in cerebral blood velocity before and after treatment were observed. And in the animal experiment, the authors adopted bilateral ligation of cervical carotid communis artery to establish CCI rat models in order to observe the effect of YXQNG and ND on incubation period of vertigo in rats and on memory performance.Results: After clinical treatment, the vertigo score of YXQNG group was 2.34, and that of the ND group was 4.18, the comparison between the two groups showed that the difference was significant (P< 0.05). After treatment, the middle cerebral artery mean velocity (MCA Vm) of YXQNG group was 64.78 cm/s, vertebral artery mean velocity (VA Vm) was 29.78 cm/s, while that of ND group was 60.34 cm/s and 23.23 cm/s respectively, the comparison between these two groups showing statistical significance and the difference being obvious (P<0.05). Experimental study showed that the rats in the model group after 12 weeks learning and memory were markedly lowered, the vertigo incubation period significantly lengthened, and compared with that of the model group, learning and memory of the YXQNG group was markedly improved and vertigo incubation period shortened, with the difference from that of the ND group insignificant,P >0.05.Conclusion: YXQNG could effectively improve CCI patients’ vertigo and other clinical symptoms and increase the cerebral blood flow, lessen the vertigo incubation of model group rats, elevate model group rats’ memory performance.  
        Keywords：Yangxue Qingnao granule;chronic cerebrovascular insufficiency;vertigo;memory performance   
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      • Yu Su-ping,Ye Hui,Ha Nan-lin,Ding Shu-qing,Chen Gao
        2005, 11(1): 27-30. DOI: 10.1007/BF02835744
        Abstract：Objective: To explore the mechanism in patients with irritable bowel syndrome (IBS) of the constipation predominant type and observe the therapeutic effects of Sinisan (SNS).Methods: Forty-seven IBS patients with the constipation predominant type were randomly divided into the treated group (n = 24) and the control group (n = 23). Another group of 22 healthy subjects was set up for healthy control. The treated group was treated with modified SNS, and the control group was treated with Cisapride, the therapeutic course for both groups was 8 weeks. The changes of symptom scoring and anorectal manometry (the anorectal resting pressure, anal tract systolic pressure, anal tract diastolic pressure, rectal threshold feeling, maximal tolerance volume of rectum, and rectum compliance) of these two groups were recorded respectively and compared with each other.Results: Compared with the healthy control group, the rectal threshold feeling, maximal tolerance volume of rectum and rectal compliance of the treated groups got reduced significantly before treatment (P<0.05). After treatment, the symptom scoring, rectal threshold feeling and maximal tolerance volume of rectum were improved in both groups (P<0.05), and the improvement of the treated group was more significant than that of the control group(P<0. 01). The total effective rate and recurrence rate of the treated group were superior to those of the control group significantly (P<0.05,P<0.01).Conclusion: SNS has good effect on IBS of the constipation predominant type.  
        Keywords：Irritable Bowel Syndrome;constipation-predominant type;Anorectal Manometry;Sinisan   
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        Published：2021-08-27
      • Wei Ling,Tan Jie
        2005, 11(1): 31-33. DOI: 10.1007/BF02835745
        Abstract：Objective: To evaluate the efficacy of Breviscapine on essential hypertension (EH) patients complicated with micro-albuminuria of renal impairment.Methods: Seventy-six EH patients were randomly assigned to the control group and the treated group, the former was given amlodipine, captopril/uropidil and the latter was given in addition Breviscapine intravenously dripped for 2 treatment courses. The indexes of serum creatinine (Cr), blood urea nitrogen (BUN), blood and urinary β2-microglobulin (β2-MG), and quantitative determination of 24 hrs urinary protein were evaluated before and after treatment.Results: In the control group, compared with before treatment, the quantitative determination of 24 hrs urinary protein got reduced significantly (P<0.05), while in the treated group, both urinary β2-MG and quantitative determination of 24 hrs urinary protein got lowered significantly (P<0.05 andP<0.01). But after treatment, compared with the control group, urinary β2-MG and quantitative determination of 24 hrs urinary protein in the treated group were obviously reduced (P<0.05).Conclusion: Besides lowering blood pressure effectively, Breviscapine could improve the renal function significantly and reduce the urinary micro-albuminuria, hence showing promising effect on renal protection.  
        Keywords：Breviscapine;Essential Hypertension;micro-albuminuria;renal impairment   
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      • Wang Wen-ling,Su You-ming,Yang Rong-ya,Zhang Jie,Xu Yang
        2005, 11(1): 34-36. DOI: 10.1007/BF02835746
        Abstract：Objective: To investigate the therapeutic effects of vitamine B6 (Vit B6) and Xuefu Zhuyu Decoction (XFZY, for activating blood circulation to remove stasis) in patients with localized scleroderma(LSD).Methods: Thirty-three patients were treated with XFZY and Vit B6, with 15 cases taking orally prednisone acetate and 20 healthy volunteers as the control. Their level of soluble interleukin-2 receptor (sIL-2R) and tumor necrosis factor-α (TNF-α) in the patients with LSD before and after treatment were observed.Results: The level of sIL-2R and TNF-α in the serum from the patients with LSD were higher than those of healthy volunteers (P<0.01). After treatment with Vit B6 and XFZY, the level of sIL-2R and TNF-α from the patients with LSD decreased significantly (P<0.01), but there were no difference between the group taking Vit B6 plus XFZY and the group given prednisone.Conclusion: The activating blood circulation to remove stasis approach in treating LSD with integrative Chinese and Western drugs got better results, and metabolic disorder of tryptophan might be correlated with the etiology of LSD.  
        Keywords：localized scleroderma;integrative Chinese and Western drugs;follow-up of efficacy   
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      • Huang Jia-dong,Song Zhao,Li Jing,Wu Bao-yan,Yin Hui-jun,Chen Ke-ji,Chen Qiang
        2005, 11(1): 37-40. DOI: 10.1007/BF02835747
        Abstract：Objective: To study the targeted point and mechanism of the function of the blood-activating and stasis-removing Chinese drugs, Paeoniae Radix 801(PR801) in its cardiovascular protective effects and its specific binding with endothelin 1(ET-1) as well as the dynamics of the two’s interactive function by means of using affinity biosensors: IAsys Plus and quartz crystal microbalance (IAQCM).Methods: ET-1 was immobilized on the surfaces of IAQCM by using the new surface modification methods. The PR801 in the solution was detected by modified substrates and the specific binding between PR801 and ET-1 was studied.Results: The curves went up or down after adding PR801. There is specific binding between PR801 and ET-1. The bound mass were 0.458 ng/mm2 and 133. 54 ng/cm2, respectively. There exists relatively good stability with these two methods.Conclusion: The affinity biosensors: IAQCM can be used to study the interaction mechanism between PR801 and ET-1, providing a new way to study the interaction mechanism of TCM. PR801 can bind ET-1 specifically in the experiments. Therefore, ET-1 is another target that PR801 can bind specifically besides thromboxane A2.  
        Keywords：activating blood circulation to remove stasis;Paeoniae Radix 801;endothelin-1;affinity biosensors   
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      • Liu Yan-juan,Huang Guang-ying,Yang Ming-wei,Gong ping,Zhang Ming-min,Lu Fu-er
        2005, 11(1): 41-44. DOI: 10.1007/BF02835748
        Abstract：Objective: To explore the effect of Jiantaiye (JTY) on the expression of estrogen receptor (ER) and ER mRNA in uterus of mice with embryo implantation dysfunction.Methods: Embryo implantation dysfunction mouse models were induced with mifepristone and treated with JTY. All animals were sacrificed on day 8 of pregnancy. The endometrial ER and ER mRNA expressions were assessed by immunno-histochemical SP method and semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR).Results: Area ratio and absorbency of ER in the JTY treated group’s gland and stroma were higher than those of the model group, quite similar to those of the normal control’s, and ER mRNA expression in treated group’s uterus was significantly higher than that in the models, but it was not significantly different from the normal control.Conclusion: JTY improves the endometrial development by increasing ER and ER mRNA expressions of uterus of mice with embryo implantation dysfunction.  
        Keywords：Jiantaiye;embryo implantation;estrogen receptor   
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      • Liu Yan-qing,Chen Gao-yang,Guo Shi-yu,Jiu Guang-zheng
        2005, 11(1): 45-48. DOI: 10.1007/BF02835749
        Abstract：Objective: To observe the analgesic effect of Zhitong Capsule (ZTC) and study its mechanism in adjuvant arthritis (AA) rats.Methods: Forty-eight male Sprague-Dawley rats were randomly divided into six groups with 8 rats in each group. On the first day, except to those in the normal group that were treated with normal saline, the same amount of Freund’s complete adjuvant (FCA) was given through intradermal injection into the right hind paw to all the rats in the other groups. From the 17th day of the modeling on, the rats in groups of ZTC were administered daily through gastrogavage with a dose of 1000, 500, 250 mg/kg respectively, while equal volume of normal saline was given to those in the normal group and model group, and an equal volume of aspirin (ASA) solution was given to rats in the ASA group through gastrogavage for 10 days, once per day, and on the 27th day, the analgesic effect of ZTC was measured with heat withdraw method. The activities and contents of Superoxide dismutase (SOD) and lipid peroxides (LPO) in serum were observed by spectrophotometry, and the level of beta-endorphin (β-EP) in hypothalamus were determined by the assay of immunohistochemistry.Results: ZTC showed significant effects on enhancing the pain threshold and at the same time it increased the activities of SOD and reduced the contents of LPO in serum. ZTC could also increase the level of β-EP in hypothalamus.Conclusion: ZTC has analgesic effect and its mechanism is probably related with its effect in inhibiting the level of oxygen free radicals in serum and increasing the level of β-EP of hypothalamus in rats.  
        Keywords：Zhitong Capsule;Adjuvant Arthritis;superoxide dismutase;lipid peroxides;β-endorphin   
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      • Xiong Wu-jun,Qiu Qi-yu,Qiu De-kai
        2005, 11(1): 49-53. DOI: 10.1007/BF02835750
        Abstract：Objective: To study the therapeutic effects and mechanism of Jiechangning (JCN) decoction on carrageenan induced experimental ulcerative colitis (UC).Methods: After sensitizing guinea pigs with carrageenan, we established UC animal models by free drinking water containing 2% acid degraded carrageenan (ADC). JCN decoction was orally administered once a day for 2 weeks after carrageenan treatment. Salicylazosulfapyridine (SASP) and normal saline were given to the other two groups as control. The levels of colon lipid peroxide (LPO), acid phosphatase (ACP) activity and tumor necrosis factor-α (TNF-α) were measured; colitis activity score (CAS) was carried out for assessment of the degree of tissue inflammation and injury; the colonic pathological changes were examined simultaneously with hematoxylin and eosin (HE) and toluidine blue staining used to evaluate the therapeutic effects of JCN decoction and SASP.Results: Experimental colitis models resembling human UC were successfully induced. The levels of tissue LPO, ACP activity and the content of tissue TNF-α were markedly increased in the model group as compared with the normal control group (P<0.01) and were positively correlated with CAS. JCN decoction could reverse these changes like SASP. HE staining showed that JCN decoction and SASP could reduce CAS and the degree of tissue injury, toluidine blue staining revealed that mucosa and submucosa red metachromasia pellets in JCN group and SASP group were markedly fewer than those in the model group.Conclusion: JCN decoction is effective in treating experimental UC, which provides theoretical basis for its clinical application.  
        Keywords：Jiechangning decoction;Ulcerative Colitis;Traditional Chinese Medicine Therapy   
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      • Han Jin,Zhao Yan-ling,Shan Li-mei,Huang Feng-jiao,Xiao Xiao-he
        2005, 11(1): 54-56. DOI: 10.1007/BF02835751
        Abstract：Objective: To explore the activities of Composite Artemisia Capillaris Tablet (CACT) against hepatitis B virus replicationin vitro.Methods: By means of radioimmunoassay (RIA), Dot blot and Southern blot, the surface and e antigen production of 2.2.15 cells, HBV DNA in 2.2.15 cell culture medium and that in 2.2.15 cells were examined respectively.Results: HBsAg, HBeAg values of 2.2.15 cells treated by CACT were lower than those of the control, the HBV DNA quantities in culture medium and in 2.2. 15 cells decreased as compared with those cells with no treatment by CACT given to them.Conclusion: CACT could inhibit HBV DNA replication, showing its potential antiviral activity in hepatitis B treatment.  
        Keywords：Composite Artemisia Capillaris Tablet;2.2.15 cells;surface antigen;e antigen;HBV DNA   
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      • Guo Yan,Fan Li,Dong Liu-yi,Chen Zhi-wu
        2005, 11(1): 57-59. DOI: 10.1007/BF02835752
        Abstract：Objective: To study the effects of total flavone of Abelmoschl Manihot L. Medic (TFA) on the function of platelets and to explore its mechanism.Methods: Rat models of artery-veins bypassing thrombus formation were used. The platelets of rabbits were collected. Platelet aggregation was induced by collagen and intracellular calcium ion concentration ([Ca2+]i) was assayed by Fura-2 method.Results: TFA (25, 50, 100 mg/kg) significantly and dose-dependently reduced the weight of thrombus. TFA (0.025, 0.05, 0.1 mg/ ml) possessed dose-dependant inhibitory effects on rabbits’ platelet aggregation induced by collagen. TFA significantly reduced the resting and CaCl2-induced increase of free intracellular calcium concentration ([Ca2+]i) in rabbit plateletin vitro.Conclusion: TFA has an antiplatelet effect via the inhibition on the influx of Ca2+.  
        Keywords：total flavone of Abelmoschl Manihot L. Medic;thrombosis;Platelet Aggregation;calcium;Fura-2   
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      • Zhou Yong-ming,Huang Zhen-qiao,Hu Ming-hui,Zhou Shao-hong,Huang Tao,Xu Yi,Lu Jia-hui,Gan Xiao-fang,Zhu Wen-wei
        2005, 11(1): 60-64. DOI: 10.1007/BF02835753
        Abstract：Objective: To observe the clinical effect of Shengxueling (SXL) on idiopathic thrombocytopenic purpura (ITP), and study the possible mechanism.Methods: Eighty-six cases of ITP were randomly divided into two groups. The SXL group, 56 patients treated with SXL, a traditinal Chinese medicine and 30 patients administered with prednisone were taken as control. Each group took drugs for 3 months and was under follow-up observation.Results: In the SXL group, the total effective rate was 85. 71%, similar to prednisone 83. 33%(P>0. 05) for 3 months, but the total effective rate of SXL (91.07%) were obviously better than that of the control group (53. 33%) (P<0.01) for 6 months and had no obvious adverse reaction. The patients bleeding was alleviated or stopped, the general condition was improved. At the same time, blood platelet count (PLT) was increased, platelet associated immunoglobulin (PAIg) and interleukin-4 (IL-4) were markedly dropped, the level of natural killers cells activity (NKa) increased, the rate of T lymphocyte subsets gradually returned to normal level. Megakaryocyte tended to maturation on bone marrow smear after treatment. All differences above were statistically significant.Conclusion: SXL is an effective and safe medicine for ITP. Its mechanism could regulate cytoimmune, inhibit platelet antibody to reduce the destruction of platelet, increase the number of platelet, promote the division and maturation of megakaryocyte, facilitate the production and release of platelet, lower the fragility of capillary, prevent and cure hemorrhagic tendency.  
        Keywords：Shengxueling;Idiopathic Thrombocytopenic Purpura;Traditional Chinese Medicine Therapy   
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      • Cheng Shi-ping,Liu Jia-lin,Yuan Jing
        2005, 11(1): 65-68. DOI: 10.1007/BF02835754
        Abstract：Objective: to explore the mechanism of leeching in treating systemic lupus erythematosus (SLE).Methods: Forty-four patients with SLE were randomly divided into conventional corticosteroid treated group (control group,n = 20) and conventional treatment group with leeching intervention added (leeching group,n = 24). Before and after treatment the concentration of plasma endothelin (ET) and soluble interleukin-2 receptor (sIL-2R) were determined.Results: Before treatment the level of plasma ET and sIL-2R in the SLE patients were all higher than those in the normal healthy group, (P<0.01). But after treatment the level of these in both groups were significantly improved than those of before treatment (P<0.05), and comparison between these two treated groups showed that the difference between them was significant (P<0.05).Conclusion: Leeching added to conventional treatment of SLE could be more effective in improving the level of plasma ET and sIL-2R, and ameliorating the impairment of renal tissues.  
        Keywords：systemic lupus erythematosus;endothelin;soluble interleukin-2 receptor;leech   
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      • Wang Ning
        2005, 11(1): 69-71. DOI: 10.1007/BF02835755
        Abstract：Objective: To explore the clinical efficacy of the principle of activating blood circulation to break stasis (ABCBS) and its influence on platelet membranous protein particle (GMP-140) and D2 dimer (D-dimer) before and after treatment.Methods: Eighty-eight patients with blood stasis syndrome (BSS) of acute cerebral infarction (ACI) were randomly divided into two groups, both of which were treated with conventional treatment, i. e. with western medicine (WM), with Salvia injection added through intravenously dripping. One of the two groups was used as the control and the other group as the treated group who had ABCBS herbs orally taken in addition. The duration of treatment course for both groups was 3 weeks.Results: There were changes in both groups over clinical symptoms, nerve function deficit scoring and GMP-140, D-dimer, but the treated group showed significantly better than that of the control group, (P<0.05).Conclusion: ABCBS principle could serve as an important auxiliary treating method for BSS of ACI, as it can effectively alter the blood of ACI patients which was viscous, condense, coagulant and aggregating.  
        Keywords：principle of activating blood circulation to break stasis;acute cerebral infarction;platelet membranous protein particle;D2 dimer   
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        ReviewPaper

      • Zhu Fang-shi,Si Jian-min
        2005, 11(1): 76-80. DOI: 10.1007/BF02835759
        Abstract：The gene-expression changes related with precancerous lesion of gastric cancer (PLGC) are surveyed. Not only the regulative effect of traditional Chinese medicine (TCM) on oncogene, antioncogene and anti-apoptosis gene that are related with PLGC is analyzed, but also current research state is presented. It’s showed that TCM has effects of therapy and inversion on PLGC. These effects are related with the inhibition to related oncogene expression, the regulation and activation to the deletion of antioncogene, the inhibition to the high-expression of mutant gene-protein about antioncogene, and the regulative function to anti-apoptosis gene.  
        Keywords：precancerous lesion of gastric cancer;gene;gene-protein;Traditional Chinese Medicine   
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